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Proc
Gene Detail
 Symbol
Name
ID
Proc
protein C
MGI:97771
Synonyms inactivator of coagulation factors Va, VIII, PC
Feature Type protein coding gene
Genetic Map
Chromosome 18
17.94 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:32123129-32139570 bp, - strand
From Ensembl annotation of GRCm38

  16442 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37288  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: coagulation factor X
Gene Tree: Proc

Human
homologs
Human Homolog PROC, protein C (inactivator of coagulation factors Va and VIIIa)
NCBI Gene ID 5624
neXtProt AC  NX_P04070
Human Synonyms  APC, PC, PROC1, THPH3, THPH4
Human Chr (Location)  2q13-q14; chr2:127418420-127429246 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PROC
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of the locus results in death within 24 hours of birth due to consumptive coagulopathy. Thromboses and bleeding are observed in the brains and livers of homozygous mutant mice.
 
Phenotype Images(2)
Interactions
Proc interacts with 29 markers (Mir98, Mir149, Mir155, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, extracellular space
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (37)    Tissues (12)    Images (24)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 24
Northern blot 4
RT-PCR 9
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(21) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024386 (Evidence)
Entrez Gene19123 (Evidence)
DFCITC1584816, TC1584933, TC1607415, TC1642543, TC1653725, TC1688628
DoTSDT.55100055, DT.55108080, DT.91446672, DT.94307288, DT.99839208
EC3.4.21.69
Consensus CDS ProjectCCDS29116.1
International Mouse Knockout Project StatusProc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024386 Ensembl Gene Model | MGI Sequence Detail 16442 C57BL/6J ±  kb
transcript ENSMUST00000171765 Ensembl | MGI Sequence Detail 1566 Not Applicable 
polypeptide ENSMUSP00000132226 Ensembl | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(11) UniProt(1)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013261 vitamin K-dependent protein C
References (Earliest) J:1257 Tada N, et al., Isolation and characterization of a mouse protein C cDNA. J Biochem. 1992 Apr;111(4):491-5
(Latest) J:180444 Vetrano S, et al., Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19830-5
All references(48)
Other
accession IDs
MGD-MRK-13625

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory