Proc
Gene Detail

Symbol Name ID

Proc protein C MGI:97771

Synonyms

inactivator of coagulation factors Va, VIII, PC

Feature Type

protein coding gene

Genetic Map

Chromosome 18

17.94 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:32123129-32139570 bp, - strand From Ensembl annotation of GRCm38   16442 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37288  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: coagulation factor X
Gene Tree: Proc

Human homologs

Human Homolog		PROC, protein C (inactivator of coagulation factors Va and VIIIa)
NCBI Gene ID		5624
neXtProt AC		NX_P04070
Human Synonyms		APC, PC, PROC1, THPH3, THPH4
Human Chr (Location)		2q13-q14; chr2:128175996-128186822 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PROC

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Inactivation of the locus results in death within 24 hours of birth due to consumptive coagulopathy. Thromboses and bleeding are observed in the brains and livers of homozygous mutant mice.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	blood coagulation, hemostasis, ...
Component	extracellular region, extracellular space
Function	calcium ion binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (37)    Tissues (12)    Images (24)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	24
Northern blot	4
RT-PCR	9

cDNA source data(82)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(85) Genomic(1) cDNA(83) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000024386 (Evidence)
Entrez Gene	19123 (Evidence)
UniGene	2786
DFCI	TC1584816, TC1584933, TC1607415, TC1642543, TC1653725, TC1688628
DoTS	DT.55100055, DT.55108080, DT.91446672, DT.94307288, DT.99839208
EC	3.4.21.69
Consensus CDS Project	CCDS29116.1
International Mouse Knockout Project Status	Proc

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024386	Ensembl Gene Model | MGI Sequence Detail	16442	C57BL/6J
transcript	ENSMUST00000171765	Ensembl | MGI Sequence Detail	1566	Not Applicable
polypeptide	ENSMUSP00000132226	Ensembl | MGI Sequence Detail	460	Not Applicable

All sequences(41) RefSeq(7) UniProt(1)

Polymorphisms

SNPs(127 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017857	Coagulation factor, subgroup, Gla domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR012224	Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000013261	vitamin K-dependent protein C

References

(Earliest) J:1257 Tada N, et al., Isolation and characterization of a mouse protein C cDNA. J Biochem. 1992 Apr;111(4):491-5
(Latest) J:180444 Vetrano S, et al., Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19830-5
All references(49)

Other accession IDs

MGD-MRK-13625