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Proc Gene Detail
Summary
  • Symbol
    Proc
  • Name
    protein C
  • Synonyms
    inactivator of coagulation factors Va, VIII, PC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97771
    NCBI Gene: 19123
  • Gene Overview
    MyGene.info: PROC
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:32123129-32139570 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16442 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 17.94 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PROC, protein C, inactivator of coagulation factors Va and VIIIa
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PROC, protein C, inactivator of coagulation factors Va and VIIIa
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APC, PC, PROC1, THPH3, THPH4
  • Links
    NCBI Gene ID: 5624
    neXtProt AC: NX_P04070
    UniProt: P04070

  • Chr Location
    2q14.3; chr2:127418221-127429246 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PROC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    41 phenotypes from multigenic genotypes
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of the locus results in death within 24 hours of birth due to consumptive coagulopathy. Thromboses and bleeding are observed in the brains and livers of homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024386 Ensembl Gene Model | MGI Sequence Detail 16442 C57BL/6J ±  kb
    transcript ENSMUST00000171765 Ensembl | MGI Sequence Detail 1566 Not Applicable  
    polypeptide ENSMUSP00000132226 Ensembl | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      133 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
      IPR009003 Peptidase S1, PA clan
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
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    • All nucleic 24
      Genomic 1
      cDNA 22
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13625
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:1257 Tada N, et al., Isolation and characterization of a mouse protein C cDNA. J Biochem. 1992 Apr;111(4):491-5
    • Latest
      J:251456 Ranjan S, et al., Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells. Nat Commun. 2017 Aug 21;8(1):311

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory