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Proc Gene Detail
Summary
  • Symbol
    Proc
  • Name
    protein C
  • Synonyms
    inactivator of coagulation factors Va, VIII, PC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97771
    NCBI Gene: 19123
  • Gene Overview
    MyGene.info: PROC
Location & Maps
more
  • Sequence Map
    Chr18:32123129-32139570 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16442 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PROC, protein C, inactivator of coagulation factors Va and VIIIa
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PROC, protein C, inactivator of coagulation factors Va and VIIIa
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APC, PC, PROC1, THPH3, THPH4
  • Links
    NCBI Gene ID: 5624
    neXtProt AC: NX_P04070

  • Chr Location
    2q13-q14; chr2:127418405-127429246 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human PROC associations

Human Disease Mouse Models
       Thrombophilia Due to Protein C Deficiency, Autosomal Dominant; THPH3   OMIM: 176860
Thrombophilia Due to Protein C Deficiency, Autosomal Recessive; THPH4   OMIM: 612304
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    41 phenotypes from multigenic genotypes
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Inactivation of the locus results in death within 24 hours of birth due to consumptive coagulopathy. Thromboses and bleeding are observed in the brains and livers of homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024386 Ensembl Gene Model | MGI Sequence Detail 16442 C57BL/6J ±  kb
transcript ENSMUST00000171765 Ensembl | MGI Sequence Detail 1566 Not Applicable  
polypeptide ENSMUSP00000132226 Ensembl | MGI Sequence Detail 460 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    133 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013261 vitamin K-dependent protein C
  • EC
  • InterPro Domains
    IPR017857 Coagulation factor, subgroup, Gla domain
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 23
    Genomic 1
    cDNA 21
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-13625
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:1257 Tada N, et al., Isolation and characterization of a mouse protein C cDNA. J Biochem. 1992 Apr;111(4):491-5
  • Latest
    J:180444 Vetrano S, et al., Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19830-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory