About   Help   FAQ
Srgn Gene Detail
Summary
  • Symbol
    Srgn
  • Name
    serglycin
  • Synonyms
    Prg1, Sgc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97756
    NCBI Gene: 19073
  • Gene Overview
    MyGene.info: SRGN
Location & Maps
more
  • Sequence Map
    Chr10:62493833-62527451 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33619 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.42 cM, cytoband B4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SRGN, serglycin
  • Vertebrate Orthologs
    2
  • Human Ortholog
    SRGN, serglycin
    Orthology source: HGNC
  • Synonyms
    PPG, PRG, PRG1
  • Links
    NCBI Gene ID: 5552
    neXtProt AC: NX_P10124

  • Chr Location
    10q22.1; chr10:69088072-69104811 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Srgn
  • Incidental Mutations
Mice homozygous for disruptions in this gene lack peritoneal mast cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024719 VEGA Gene Model | MGI Sequence Detail 33619 C57BL/6J ±  kb
transcript OTTMUST00000060836 VEGA | MGI Sequence Detail 1727 Not Applicable  
polypeptide OTTMUSP00000029732 VEGA | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    174 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 111
    Genomic 6
    cDNA 102
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13606, MGD-MRK-14384
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 22
  • Earliest
    J:9815 Avraham S, et al., Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA. Proc Natl Acad Sci U S A. 1989 May;86(10):3763-7
  • Latest
    J:235422 Hamilton A, et al., Loss of Serglycin Promotes Primary Tumor Growth and Vessel Functionality in the RIP1-Tag2 Mouse Model for Spontaneous Insulinoma Formation. PLoS One. 2015;10(5):e0126688

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory