Sequence Detail

ID/Version

P13609 Q3TZD4 Q8C2U2 (UniProt | EBI)

Last sequence update: 1990-01-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Serglycin;AltName: Full=Mastocytoma proteoglycan core protein;AltName: Full=Secretory granule proteoglycan core protein;AltName: Full=gp600;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 152 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Srgn	serglycin	36	103	3	10

Sequence references in MGI

J:9815 Avraham S, et al., Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA. Proc Natl Acad Sci U S A. 1989 May;86(10):3763-7
J:10804 Angerth T, et al., Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein; analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome. Gene. 1990 Sep 14;93(2):235-40
J:25019 Kjellen L, et al., Primary structure of a mouse mastocytoma proteoglycan core protein. Biochem J. 1989 Oct 1;263(1):105-13
J:93338 Abrink M, et al., Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem. 2004 Oct 24;279(39):40897-905
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116939 Zernichow L, et al., Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J Biol Chem. 2006 Sep 15;281(37):26792-801
J:121395 Braga T, et al., Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. Biochem J. 2007 Apr 1;403(1):49-57
J:122713 Toyama-Sorimachi N, et al., A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation. J Biol Chem. 1995 Mar 31;270(13):7437-44
J:122887 Lundequist A, et al., Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases. Biol Chem. 2006 Oct-Nov;387(10-11):1513-9
J:123217 Grujic M, et al., Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J Biol Chem. 2005 Sep 30;280(39):33411-8
J:126962 Henningsson F, et al., A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J. 2006 Nov;273(21):4901-12
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89