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Ppia Gene Detail
Summary
  • Symbol
    Ppia
  • Name
    peptidylprolyl isomerase A
  • Synonyms
    Cphn, cyclophilin A, CyP-18, CypA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97749
    NCBI Gene: 268373
  • Gene Overview
    MyGene.info: PPIA
Location & Maps
more
  • Genetic Map
    Chromosome 11, 3.97 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPIA, peptidylprolyl isomerase A
  • Vertebrate Orthologs
    12
  • Human Ortholog
    PPIA, peptidylprolyl isomerase A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYPA, CYPH, HEL-S-69p
  • Links
    NCBI Gene ID: 5478
    neXtProt AC: NX_P62937

  • Chr Location
    7p13; chr7:44796636-44803123 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    17
  • Targeted
    3
Mice homozygous for disruptions in this gene tend to develop blepharitis (about 30% of mice) as well as inflammation in other organs. Some background dependent embryonic lethality occurs but adults are robust and live normal life spans.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000783 VEGA Gene Model | MGI Sequence Detail 4375 C57BL/6J ±  kb
transcript OTTMUST00000001541 VEGA | MGI Sequence Detail 1170 Not Applicable  
polypeptide OTTMUSP00000000741 VEGA | MGI Sequence Detail 164 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013075 peptidyl-prolyl cis-trans isomerase A
  • EC
  • InterPro Domains
    IPR029000 Cyclophilin-like domain
    IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Molecular
Reagents
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  • All nucleic 41
    cDNA 35
    Primer pair 6

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-13591, MGD-MRK-2108
References
more
  • Summaries
    All 84
    Developmental Gene Expression 23
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:37376 Handschumacher RE, et al., Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7
  • Latest
    J:224102 Guo M, et al., Novel role for cyclophilin A in regulation of chondrogenic commitment and endochondral ossification. Mol Cell Biol. 2015 Jun;35(12):2119-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory