About   Help   FAQ
Pold1
Gene Detail
Symbol

Name
ID
Pold1
polymerase (DNA directed), delta 1, catalytic subunit
MGI:97741
Synonyms
125kDa
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:44532746-44548849 bp, - strand
From VEGA annotation of GRCm38

  16104 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2014  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA polymerase
Gene Tree: Pold1

Human
homologs
Human Homolog POLD1, polymerase (DNA directed), delta 1, catalytic subunit
NCBI Gene ID 5424
neXtProt AC  NX_P28340
Human Synonyms  CDC2, CRCS10, MDPL, POLD
Human Chr (Location)  19q13.3; chr19:50384278-50418018 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human POLD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(13) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have an elevated mutation rate as well as an increased incidence of tumors. Median age for these mice is around 10 months.
 
Phenotype Images(4)
Interactions
Pold1 interacts with 49 markers (Mir18, Mir18b, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process base-excision repair, gap-filling, DNA biosynthetic process, ...
Component aggresome, cytoplasm, ...
Function 3'-5' exonuclease activity, 4 iron, 4 sulfur cluster binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (118)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 140
cDNA source data(117)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(120) Genomic(1) cDNA(117) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028995 (Evidence)
Ensembl Gene ModelENSMUSG00000038644 (Evidence)
Entrez Gene18971 (Evidence)
UniGene16549
DFCITC1572909
DoTSDT.101737553, DT.492142, DT.94272153, DT.94272164
NIA Mouse Gene IndexU028492
EC2.7.7.7
Consensus CDS ProjectCCDS21210.1
International Mouse Knockout Project StatusPold1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028995 VEGA Gene Model | MGI Sequence Detail 16104 C57BL/6J ±  kb
transcript OTTMUST00000071903 VEGA | MGI Sequence Detail 3454 Not Applicable 
polypeptide OTTMUSP00000036922 VEGA | MGI Sequence Detail 1105 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(2) UniProt(9)
Polymorphisms
PCR(1) : SNPs within 2kb(178 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025687 C4-type zinc-finger of DNA polymerase delta
InterPro IPR006172 DNA-directed DNA polymerase, family B
InterPro IPR017964 DNA-directed DNA polymerase, family B, conserved site
InterPro IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
InterPro IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
InterPro IPR023211 DNA polymerase, palm domain
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000012963 DNA polymerase delta catalytic subunit
References
(Earliest) J:16041 Cullmann G, et al., Cloning of a mouse cDNA encoding DNA polymerase delta: refinement of the homology boxes. Gene. 1993 Dec 8;134(2):191-200
(Latest) J:195870 Zhou W, et al., Use of somatic mutations to quantify random contributions to mouse development. BMC Genomics. 2013;14:39
All references(44)
Other
accession IDs
MGD-MRK-13579

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory