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Pnmt
Gene Detail
Symbol

Name
ID
Pnmt
phenylethanolamine-N-methyltransferase
MGI:97724
Synonyms
Pent
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.75 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:98386450-98388181 bp, + strand
From VEGA annotation of GRCm38

  1732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55673  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PNMT
Protein SuperFamily: phenylethanolamine N-methyltransferase
Gene Tree: Pnmt

Human
homologs
PNMT, phenylethanolamine N-methyltransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5409
neXtProt AC: NX_P11086

Human Synonyms: PENT, PNMTase

Human Chr (Location): 17q12; chr17:39667981-39670475 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Pnmt (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice lack adrenal epinephrine and have increased adrenal norepinephrine levels but are viable and fertile.
 
Interactions
Pnmt interacts with 9 markers (Mir125a, Mir152, Mir668, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process catecholamine biosynthetic process, epinephrine biosynthetic process, ...
Component axon, cytoplasm, ...
Function methyltransferase activity, phenylethanolamine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (109)    Tissues (100)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 99
RT-PCR 6
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pnmt    NEW 
Molecular
reagents
All nucleic(11) Genomic(3) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002714 (Evidence)
Ensembl Gene Model ENSMUSG00000038216 (Evidence)
Entrez Gene 18948 (Evidence)
UniGene 57030
DFCI TC1613037
DoTS DT.55273843
NIA Mouse Gene Index U013297
EC 2.1.1.28
Consensus CDS Project CCDS25347.1
International Mouse Phenotyping Consortium Status Pnmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002714 VEGA Gene Model | MGI Sequence Detail 1732 C57BL/6J ±  kb
transcript OTTMUST00000005376 VEGA | MGI Sequence Detail 1154 Not Applicable 
polypeptide OTTMUSP00000002543 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000940 Methyltransferase, NNMT/PNMT/TEMT
InterPro IPR025820 Methyltransferase NNMT/PNMT/TEMT, conserved site
Protein Ontology PR:000012937 phenylethanolamine N-methyltransferase
References
(Earliest) J:1117 Morita S, et al., Organization and complete nucleotide sequence of the gene encoding mouse phenylethanolamine N-methyltransferase. Brain Res Mol Brain Res. 1992 May;13(4):313-9
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(59)
Other
accession IDs
MGD-MRK-13230, MGD-MRK-13546

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory