Pnmt
Gene Detail

Symbol Name ID

Pnmt phenylethanolamine-N-methyltransferase MGI:97724

Synonyms

Pent

Feature Type

protein coding gene

Genetic Map

Chromosome 11

61.75 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:98386450-98388181 bp, + strand From VEGA annotation of GRCm38   1732 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55673  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phenylethanolamine N-methyltransferase
Gene Tree: Pnmt

Human homologs

Human Homolog		PNMT, phenylethanolamine N-methyltransferase
NCBI Gene ID		5409
neXtProt AC		NX_P11086
Human Synonyms		PENT, PNMTase
Human Chr (Location)		17q; chr17:37824507-37826728 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PNMT

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice lack adrenal epinephrine and have increased adrenal norepinephrine levels but are viable and fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	catecholamine biosynthetic process
Function	methyltransferase activity, transferase activity

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (107)    Tissues (99)    Images (5)
Theiler Stages: 22, 23, 25

Assay Type	Results
Immunohistochemistry	2
RNA in situ	99
RT-PCR	6

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(3) cDNA(7) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002714 (Evidence)
Ensembl Gene Model	ENSMUSG00000038216 (Evidence)
Entrez Gene	18948 (Evidence)
UniGene	57030
DFCI	TC1613037
DoTS	DT.55273843
NIA Mouse Gene Index	U013297
EC	2.1.1.28
Consensus CDS Project	CCDS25347.1
International Mouse Knockout Project Status	Pnmt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002714	VEGA Gene Model | MGI Sequence Detail	1732	C57BL/6J
transcript	OTTMUST00000005376	VEGA | MGI Sequence Detail	1154	Not Applicable
polypeptide	OTTMUSP00000002543	VEGA | MGI Sequence Detail	295	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000940	Methyltransferase, NNMT/PNMT/TEMT
InterPro	IPR025820	Methyltransferase NNMT/PNMT/TEMT, conserved site
Protein Ontology	PR:000012937	phenylethanolamine N-methyltransferase

References

(Earliest) J:1117 Morita S, et al., Organization and complete nucleotide sequence of the gene encoding mouse phenylethanolamine N-methyltransferase. Brain Res Mol Brain Res. 1992 May;13(4):313-9
(Latest) J:191801 Huang CC, et al., Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. Endocrinology. 2012 Oct;153(10):4749-56
All references(52)

Other accession IDs

MGD-MRK-13230, MGD-MRK-13546