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Pnmt
Gene Detail
 Symbol
Name
ID
Pnmt
phenylethanolamine-N-methyltransferase
MGI:97724
Synonyms Pent
Feature Type protein coding gene
Genetic Map
Chromosome 11
61.75 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:98386450-98388181 bp, + strand
From VEGA annotation of GRCm38

  1732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55673  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: phenylethanolamine N-methyltransferase
Gene Tree: Pnmt

Human
homologs
Human Homolog PNMT, phenylethanolamine N-methyltransferase
NCBI Gene ID 5409
neXtProt AC  NX_P11086
Human Synonyms  PENT, PNMTase
Human Chr (Location)  17q; chr17:39667981-39670475 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PNMT
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice lack adrenal epinephrine and have increased adrenal norepinephrine levels but are viable and fertile.
 
Interactions
Pnmt interacts with 9 markers (Mir125a, Mir152, Mir668, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process catecholamine biosynthetic process, epinephrine biosynthetic process, ...
Component axon, cytoplasm, ...
Function methyltransferase activity, phenylethanolamine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (107)    Tissues (99)    Images (5)
Theiler Stages: 22, 23, 25
Assay TypeResults
Immunohistochemistry 2
RNA in situ 99
RT-PCR 6
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(3) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002714 (Evidence)
Ensembl Gene ModelENSMUSG00000038216 (Evidence)
Entrez Gene18948 (Evidence)
UniGene57030
DFCITC1613037
DoTSDT.55273843
NIA Mouse Gene IndexU013297
EC2.1.1.28
Consensus CDS ProjectCCDS25347.1
International Mouse Knockout Project StatusPnmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002714 VEGA Gene Model | MGI Sequence Detail 1732 C57BL/6J ±  kb
transcript OTTMUST00000005376 VEGA | MGI Sequence Detail 1154 Not Applicable 
polypeptide OTTMUSP00000002543 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000940 Methyltransferase, NNMT/PNMT/TEMT
InterPro IPR025820 Methyltransferase NNMT/PNMT/TEMT, conserved site
Protein Ontology PR:000012937 phenylethanolamine N-methyltransferase
References (Earliest) J:1117 Morita S, et al., Organization and complete nucleotide sequence of the gene encoding mouse phenylethanolamine N-methyltransferase. Brain Res Mol Brain Res. 1992 May;13(4):313-9
(Latest) J:208894 VanDusen NJ, et al., Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death. Dev Biol. 2014 Apr 15;388(2):149-58
All references(58)
Other
accession IDs
MGD-MRK-13230, MGD-MRK-13546

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory