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Prrx1 Gene Detail
Summary
  • Symbol
    Prrx1
  • Name
    paired related homeobox 1
  • Synonyms
    A230024N07Rik, K-2, mHox, mHox, Pmx1, Prx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97712
    NCBI Gene: 18933
  • Gene Overview
    MyGene.info: PRRX1
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:163245119-163313705 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 70.53 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    594 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97712
protein coding gene Chr1:163245119-163313710 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016670
protein coding gene Chr1:168639417-168706743 (-)
A/J MGP_AJ_G0016651
protein coding gene Chr1:161756980-161824083 (-)
AKR/J MGP_AKRJ_G0016617
protein coding gene Chr1:166674576-166745358 (-)
BALB/cJ MGP_BALBcJ_G0016612
protein coding gene Chr1:162260541-162327754 (-)
C3H/HeJ MGP_C3HHeJ_G0016436
protein coding gene Chr1:166849768-166917566 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017073
protein coding gene Chr1:174294278-174363526 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014782
protein coding gene Chr1:153772934-153840427 (-)
CAST/EiJ MGP_CASTEiJ_G0016016
protein coding gene Chr1:166507523-166575698 (-)
CBA/J MGP_CBAJ_G0016411
protein coding gene Chr1:180517418-180586586 (-)
DBA/2J MGP_DBA2J_G0016517
protein coding gene Chr1:160672110-160738891 (-)
FVB/NJ MGP_FVBNJ_G0016515
protein coding gene Chr1:159110236-159177767 (-)
LP/J MGP_LPJ_G0016588
protein coding gene Chr1:169723600-169790313 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016540
protein coding gene Chr1:188023902-188093563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017109
protein coding gene Chr1:166483307-166551301 (-)
PWK/PhJ MGP_PWKPhJ_G0015802
protein coding gene Chr1:159865253-159931969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015589
protein coding gene Chr1:165385912-165454600 (-)
WSB/EiJ MGP_WSBEiJ_G0016078
protein coding gene Chr1:166651826-166723398 (-)



Homology
more
  • Human Ortholog
    PRRX1, paired related homeobox 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRRX1, paired related homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGOTC, PHOX1, PMX1, PRX1, PRX-1
  • Links
    NCBI Gene ID: 5396
    neXtProt AC: NX_P54821
    UniProt: P54821

  • Chr Location
    1q24.2; chr1:170662728-170739400 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7896
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRRX1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PRRX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    69 phenotypes from 4 alleles in 5 genetic backgrounds
    91 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit skeletal defects affecting mandible, limbs, and vertebrae, vascular abnormalities, and neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18933 NCBI Gene Model | MGI Sequence Detail 68587 C57BL/6J ±  kb
    transcript NM_175686 RefSeq | MGI Sequence Detail 4983 C57BL/6  
    polypeptide P63013 UniProt | EBI | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 129
      Genomic 6
      cDNA 114
      Primer pair 7
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-13532, MGI:2138130, MGI:2138219, MGI:2138338, MGI:2441785
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 67
      Gene Ontology 15
      Phenotypes 17
    • Earliest
      J:3255 Kern MJ, et al., A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy. Nucleic Acids Res. 1992 Oct 11;20(19):5189-95
    • Latest
      J:264351 Rivera-Reyes R, et al., Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins. PLoS One. 2018;13(8):e0200964

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory