Prrx1
Gene Detail

Symbol Name ID

Prrx1 paired related homeobox 1 MGI:97712

Synonyms

A230024N07Rik, K-2, mHox, mHox, Pmx1, Prx1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

70.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr1:163245116-163313710 bp, - strand From VEGA annotation of GRCm38   68595 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7896  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Prrx1

Human homologs

Human Homolog		PRRX1, paired related homeobox 1
NCBI Gene ID		5396
neXtProt AC		NX_P54821
Human Synonyms		AGOTC, PHOX1, PMX1, PRX1, PRX-1
Human Chr (Location)		1q24; chr1:170633313-170708541 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRRX1

Alleles and phenotypes

All alleles(8) : Targeted(6) Gene trapped(2)
 

Homozygotes for targeted null mutations exhibit skeletal defects affecting mandible, limbs, and vertebrae, vascular abnormalities, and neonatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	artery morphogenesis, cartilage development, ...
Component	nucleolus, nucleus
Function	DNA binding, HMG box domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (56 records)
Data Summary: Results (476)    Tissues (291)    Images (109)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	404
In situ reporter (knock in)	30
Northern blot	12
RT-PCR	30

cDNA source data(107)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(124) Genomic(6) cDNA(111) Primer pair(5) Other(2)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000037738 (Evidence)
Ensembl Gene Model	ENSMUSG00000026586 (Evidence)
Entrez Gene	18933 (Evidence)
UniGene	288642
DFCI	TC1578295, TC1588011, TC1589962, TC1597377, TC1598522, TC1620888, TC1678324, TC1720698
DoTS	DT.101136331, DT.101288471, DT.101306231, DT.101377739, DT.55140060, DT.87072480, DT.97403358
NIA Mouse Gene Index	U021977
Consensus CDS Project	CCDS15427.1, CCDS15428.1, CCDS56651.1
International Mouse Knockout Project Status	Prrx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037738	VEGA Gene Model | MGI Sequence Detail	68595	C57BL/6J
transcript	OTTMUST00000097461	VEGA | MGI Sequence Detail	4955	Not Applicable
polypeptide	OTTMUSP00000054664	VEGA | MGI Sequence Detail	245	Not Applicable

All sequences(71) RefSeq(6) UniProt(6)

Polymorphisms

RFLP(2) : SNPs(464 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003654	OAR domain
Protein Ontology	PR:000013316	paired mesoderm homeobox protein 1

References

(Earliest) J:3255 Kern MJ, et al., A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy. Nucleic Acids Res. 1992 Oct 11;20(19):5189-95
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(108)

Other accession IDs

MGD-MRK-13532, MGI:2138130, MGI:2138219, MGI:2138338, MGI:2441785