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Prrx1
Gene Detail
 Symbol
Name
ID
Prrx1
paired related homeobox 1
MGI:97712
Synonyms A230024N07Rik, K-2, mHox, mHox, Pmx1, Prx1
Feature Type protein coding gene
Genetic Map
Chromosome 1
70.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr1:163245119-163313710 bp, - strand
From VEGA annotation of GRCm38

  68592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7896  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Prrx1

Human
homologs
Human Homolog PRRX1, paired related homeobox 1
NCBI Gene ID 5396
neXtProt AC  NX_P54821
Human Synonyms  AGOTC, PHOX1, PMX1, PRX1, PRX-1
Human Chr (Location)  1q24; chr1:170662728-170739400 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRRX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit skeletal defects affecting mandible, limbs, and vertebrae, vascular abnormalities, and neonatal lethality.
 
Interactions
Prrx1 interacts with 472 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process artery morphogenesis, cartilage development, ...
Component nucleolus, nucleus
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (579)    Tissues (363)    Images (137)
Theiler Stages: 2, 3, 4, 5, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 514
In situ reporter (knock in) 30
Northern blot 12
RT-PCR 23
cDNA source data(108)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(125) Genomic(6) cDNA(112) Primer pair(5) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000037738 (Evidence)
Ensembl Gene ModelENSMUSG00000026586 (Evidence)
Entrez Gene18933 (Evidence)
UniGene288642
DFCITC1578295, TC1588011, TC1589962, TC1597377, TC1598522, TC1620888, TC1678324, TC1720698
DoTSDT.101136331, DT.101288471, DT.101306231, DT.101377739, DT.55140060, DT.87072480, DT.97403358
NIA Mouse Gene IndexU021977
Consensus CDS ProjectCCDS15427.1, CCDS15428.1, CCDS56651.1
International Mouse Knockout Project StatusPrrx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037738 VEGA Gene Model | MGI Sequence Detail 68592 C57BL/6J ±  kb
transcript OTTMUST00000097461 VEGA | MGI Sequence Detail 4952 Not Applicable 
polypeptide OTTMUSP00000054664 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(8) UniProt(7)
Polymorphisms RFLP(2) : SNPs within 2kb(595 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000013316 paired mesoderm homeobox protein 1
References (Earliest) J:3255 Kern MJ, et al., A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy. Nucleic Acids Res. 1992 Oct 11;20(19):5189-95
(Latest) J:208830 Lin SS, et al., Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1990-8
All references(112)
Other
accession IDs
MGD-MRK-13532, MGI:2138130, MGI:2138219, MGI:2138338, MGI:2441785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory