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Plp1
Gene Detail
 Symbol
Name
ID
Plp1
proteolipid protein (myelin) 1
MGI:97623
STS DXMit9, DXNds2
Synonyms DM20, Plp
Feature Type protein coding gene
Genetic Map
Chromosome X
59.10 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(64)
Sequence Map
ChrX:136822671-136839733 bp, + strand
From VEGA annotation of GRCm38

  17063 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: myelin proteolipid protein
Gene Tree: Plp1

Human
homologs
Human Homolog PLP1, proteolipid protein 1
NCBI Gene ID 5354
neXtProt AC  NX_P60201
Human Synonyms  GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2
Human Chr (Location)  Xq22; chrX:103776511-103792619 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PLP1
Alleles
and
phenotypes
All alleles(18) : Targeted(13) Gene trapped(1) Spontaneous(4)
 
Males hemizygous for X-linked missense and partially deleted mutations typically exhibit central nervous system demyelination, loss of oligodendrocytes, tremors, convulsions, and lethality, but targeted null mutants are essentially normal and fertile.
 
Human Diseases Modeled Using Mouse Plp1 (2)    Alleles Annotated to Human Diseases(4)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process axon ensheathment, cell maturation, ...
Component integral component of membrane, membrane, ...
Function protein binding, structural constituent of myelin sheath, ...
External Resources: FuncBase
Expression
Literature Summary: (87 records)
Data Summary: Results (360)    Tissues (195)    Images (36)
Theiler Stages: 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 42
RNA in situ 205
Northern blot 3
Western blot 6
RT-PCR 93
RNase protection 11
cDNA source data(74)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(118) Genomic(23) cDNA(77) Primer pair(13) Other(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016519 (Evidence)
Ensembl Gene ModelENSMUSG00000031425 (Evidence)
Entrez Gene18823 (Evidence)
UniGene1268
DFCITC1571971, TC1587231, TC1595741, TC1647914
DoTSDT.101134424, DT.101393494, DT.91344137, DT.94347953, DT.97340795
NIA Mouse Gene IndexU020231
Consensus CDS ProjectCCDS30424.1
International Mouse Knockout Project StatusPlp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016519 VEGA Gene Model | MGI Sequence Detail 17063 C57BL/6J ±  kb
transcript OTTMUST00000039923 VEGA | MGI Sequence Detail 4699 Not Applicable 
polypeptide OTTMUSP00000017800 VEGA | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(3)
Polymorphisms All PCR and RFLP(15) : PCR(5) RFLP(10) SNPs within 2kb(144 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001614 Myelin proteolipid protein PLP
InterPro IPR018237 Myelin proteolipid protein PLP, conserved site
Protein Ontology PR:000012879 myelin proteolipid protein
References (Earliest) J:288 Phillips RJS, Jimpy, a new totally sexlinked gene in the house mouse. Z Indukt Abstamm Vererbungsl. 1954;86(3):322-6
(Latest) J:198563 Chapman H, et al., The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors. Development. 2013 Jun;140(11):2289-98
All references(360)
Other
accession IDs
MGD-MRK-11530, MGD-MRK-12562, MGD-MRK-13363, MGD-MRK-14219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory