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Symbol
Name
ID

Plp1
proteolipid protein (myelin) 1
MGI:97623

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Bowel incontinence	Depression	Atypical behavior	Apathy
Disease(s) Associated with PLP1	Bowel incontinence	Depression	Atypical behavior	Apathy
hereditary spastic paraplegia 2
Pelizaeus-Merzbacher disease

Mouse Phenotypes

behavior/neurological phenotype

abnormal startle reflex

tremors

ataxia

impaired coordination

abnormal locomotor coordination

abnormal gait

decreased locomotor activity

hindlimb paralysis

paraparesis

decreased vocalization

seizures

environmentally induced seizures

tonic-clonic seizures

Availability

Mouse Genotype

Plp1^jp-rsh/Plp1^jp-rsh

*!

Plp1^tm1Wst/Plp1^tm1Wst

Plp1^tm2Wst/Plp1^tm2Wst

Tg(Plp)66Kan/Tg(Plp)66Kan

Plp1^jp-4J/Y

Plp1^jp-6J/Y

Plp1^jp-msd/Y

Plp1^jp-rsh/Y

*!

!

!

!

Plp1^jp/Y

Plp1^tm1.1Gow/Y

Plp1^tm1Frca/Y

*

Plp1^tm1Gow/Y

Plp1^tm1Kan/Y

*

Tg(Plp)66Kan/0

Plp1^tm1Kan/?

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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