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Prkcq Gene Detail
Summary
  • Symbol
    Prkcq
  • Name
    protein kinase C, theta
  • Synonyms
    A130035A12Rik, PKC-0, Pkcq, PKCtheta, PKC theta, PKC-theta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97601
    NCBI Gene: 18761
  • Gene Overview
    MyGene.info: PRKCQ
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:11172108-11301222 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 8.42 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97601
 protein coding gene Chr2:11171904-11301226 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025342
 protein coding gene Chr2:8550608-8693011 (+)
A/J MGP_AJ_G0025319
 protein coding gene Chr2:8195232-8332390 (+)
AKR/J MGP_AKRJ_G0025288
 protein coding gene Chr2:8481233-8622714 (+)
BALB/cJ MGP_BALBcJ_G0025315
 protein coding gene Chr2:8182932-8312340 (+)
C3H/HeJ MGP_C3HHeJ_G0025075
 protein coding gene Chr2:8400231-8540565 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025757
 protein coding gene Chr2:8797431-8941146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023171
 protein coding gene Chr2:7649588-7781056 (+)
CAST/EiJ MGP_CASTEiJ_G0024538
 protein coding gene Chr2:8418887-8567031 (+)
CBA/J MGP_CBAJ_G0025054
 protein coding gene Chr2:9137392-9286460 (+)
DBA/2J MGP_DBA2J_G0025186
 protein coding gene Chr2:8119569-8252984 (+)
FVB/NJ MGP_FVBNJ_G0025148
 protein coding gene Chr2:8047934-8177558 (+)
LP/J MGP_LPJ_G0025272
 protein coding gene Chr2:8474391-8614073 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025180
 protein coding gene Chr2:9065668-9204220 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025815
 protein coding gene Chr2:8408348-8550173 (+)
PWK/PhJ MGP_PWKPhJ_G0024289
 protein coding gene Chr2:8072026-8209696 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024089
 protein coding gene Chr2:8320245-8528753 (+)
WSB/EiJ MGP_WSBEiJ_G0024608
 protein coding gene Chr2:8490546-8625040 (+)



Homology
more
  • Human Ortholog
    PRKCQ, protein kinase C theta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKCQ, protein kinase C theta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    nPKC-theta, PRKCT
  • Links
    NCBI Gene ID: 5588
    neXtProt AC: NX_Q04759
    UniProt: Q04759

  • Chr Location
    10p15.1; chr10:6393038-6580646 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Prkcq mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 6 alleles in 9 genetic backgrounds
    32 phenotypes from multigenic genotypes
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced T cell proliferative responses and interleukin 2 production and a lack of T cell receptor-initiated NF-kappaB activation in mature T lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    160
  • Tissues
    89
  • cDNA Data
    39
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026778 Ensembl Gene Model | MGI Sequence Detail 129115 C57BL/6J ±  kb
    transcript ENSMUST00000028118 Ensembl | MGI Sequence Detail 3583 Not Applicable  
    polypeptide ENSMUSP00000028118 Ensembl | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 39
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13333, MGI:2139356, MGI:2442369
    References
    more
    • Summaries
      All 185
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 19
      Phenotypes 96
    • Earliest
      J:13213 Osada S, et al., A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992 Sep;12(9):3930-8
    • Latest
      J:260649 Lozanoska-Ochser B, et al., Targeting early PKCtheta-dependent T-cell infiltration of dystrophic muscle reduces disease severity in a mouse model of muscular dystrophy. J Pathol. 2018 Mar;244(3):323-333
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/13/2019
    MGI 6.14     		The Jackson Laboratory