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Prkcq Gene Detail
Summary
  • Symbol
    Prkcq
  • Name
    protein kinase C, theta
  • Synonyms
    A130035A12Rik, PKC-0, Pkcq, PKCtheta, PKC theta, PKC-theta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97601
    NCBI Gene: 18761
  • Gene Overview
    MyGene.info: PRKCQ
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:11172108-11301222 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      129115 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 8.42 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRKCQ, protein kinase C theta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKCQ, protein kinase C theta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    nPKC-theta, PRKCT
  • Links
    NCBI Gene ID: 5588
    neXtProt AC: NX_Q04759
    UniProt: Q04759

  • Chr Location
    10p15.1; chr10:6393038-6580646 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Prkcq mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 4 alleles in 7 genetic backgrounds
    32 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced T cell proliferative responses and interleukin 2 production and a lack of T cell receptor-initiated NF-kappaB activation in mature T lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    54
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    160
  • Tissues
    89
  • cDNA Data
    38
  • Literature Summary
    13
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011317 VEGA Gene Model | MGI Sequence Detail 129115 C57BL/6J ±  kb
transcript OTTMUST00000026520 VEGA | MGI Sequence Detail 3583 Not Applicable  
polypeptide OTTMUSP00000012133 VEGA | MGI Sequence Detail 707 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    438 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 38
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13333, MGI:2139356, MGI:2442369
References
more
  • Summaries
    All 158
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 19
    Phenotypes 81
  • Earliest
    J:13213 Osada S, et al., A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992 Sep;12(9):3930-8
  • Latest
    J:237977 Ji X, et al., Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, theta. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):877-88
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/10/2017
MGI 6.10 		The Jackson Laboratory