Prkcq
Gene Detail

Symbol Name ID

Prkcq protein kinase C, theta MGI:97601

Synonyms

A130035A12Rik, PKC-0, Pkcq, PKCtheta, PKC theta, PKC-theta

Feature Type

protein coding gene

Genetic Map

Chromosome 2

8.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:11172113-11301226 bp, + strand From VEGA annotation of GRCm38   129114 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein kinase C, delta/epsilon/eta/theta types
Gene Tree: Prkcq

Human homologs

Human Homolog		PRKCQ, protein kinase C, theta
NCBI Gene ID		5588
neXtProt AC		NX_Q04759
Human Synonyms		nPKC-theta, PRKCT
Human Chr (Location)		10p15; chr10:6393596-6580301 (-)  GRCh38

Alleles and phenotypes

All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations exhibit reduced T cell proliferative responses and interleukin 2 production and a lack of T cell receptor-initiated NF-kappaB activation in mature T lymphocytes.

 

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	immune system process, inflammatory response, ...
Component	cytoplasm, immunological synapse, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)

Data Summary: Results (126)    Tissues (57)    Images (27)
Theiler Stages: 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	69
Northern blot	5
Western blot	4
RT-PCR	46

cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000011317 (Evidence)
Ensembl Gene Model	ENSMUSG00000026778 (Evidence)
Entrez Gene	18761 (Evidence)
UniGene	329993
DFCI	TC1582015, TC1596310, TC1596852
DoTS	DT.101358834, DT.489838, DT.91279719, DT.97411504
NIA Mouse Gene Index	U001385
EC	2.7.11.13
PDB	4FKD
Consensus CDS Project	CCDS15682.1
International Mouse Knockout Project Status	Prkcq

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011317	VEGA Gene Model | MGI Sequence Detail	129114	C57BL/6J
transcript	OTTMUST00000026520	VEGA | MGI Sequence Detail	3313	Not Applicable
polypeptide	OTTMUSP00000012133	VEGA | MGI Sequence Detail	707	Not Applicable

All sequences(47) RefSeq(6) UniProt(7)

Polymorphisms

SNPs within 2kb(439 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR014376	Protein kinase C, delta/epsilon/eta/theta types
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR027264	Protein kinase C, theta
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000002344	protein kinase C theta type

References

(Earliest) J:13213 Osada S, et al., A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992 Sep;12(9):3930-8
(Latest) J:207012 Cho JH, et al., Unique features of naive CD8+ T cell activation by IL-2. J Immunol. 2013 Dec 1;191(11):5559-73
All references(153)

Other accession IDs

MGD-MRK-13333, MGI:2139356, MGI:2442369