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Prkcq
Gene Detail
 Symbol
Name
ID
Prkcq
protein kinase C, theta
MGI:97601
Synonyms A130035A12Rik, PKC-0, Pkcq, PKCtheta, PKC theta, PKC-theta
Feature Type protein coding gene
Genetic Map
Chromosome 2
8.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:11172113-11301226 bp, + strand
From VEGA annotation of GRCm38

  129114 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein kinase C, delta/epsilon/eta/theta types
Gene Tree: Prkcq

Human
homologs
Human Homolog PRKCQ, protein kinase C, theta
NCBI Gene ID 5588
neXtProt AC  NX_Q04759
Human Synonyms  nPKC-theta, PRKCT
Human Chr (Location)  10p15; chr10:6393596-6580301 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced T cell proliferative responses and interleukin 2 production and a lack of T cell receptor-initiated NF-kappaB activation in mature T lymphocytes.
 
Interactions
Prkcq interacts with 240 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process immune system process, inflammatory response, ...
Component cytoplasm, immunological synapse, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (126)    Tissues (58)    Images (27)
Theiler Stages: 21, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 69
Northern blot 5
Western blot 4
RT-PCR 46
cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011317 (Evidence)
Ensembl Gene ModelENSMUSG00000026778 (Evidence)
Entrez Gene18761 (Evidence)
UniGene329993
DFCITC1582015, TC1596310, TC1596852
DoTSDT.101358834, DT.489838, DT.91279719, DT.97411504
NIA Mouse Gene IndexU001385
EC2.7.11.13
PDB4FKD
Consensus CDS ProjectCCDS15682.1
International Mouse Knockout Project StatusPrkcq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011317 VEGA Gene Model | MGI Sequence Detail 129114 C57BL/6J ±  kb
transcript OTTMUST00000026520 VEGA | MGI Sequence Detail 3313 Not Applicable 
polypeptide OTTMUSP00000012133 VEGA | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(7)
Polymorphisms SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR014376 Protein kinase C, delta/epsilon/eta/theta types
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR027264 Protein kinase C, theta
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000002344 protein kinase C theta type
References (Earliest) J:13213 Osada S, et al., A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992 Sep;12(9):3930-8
(Latest) J:207012 Cho JH, et al., Unique features of naive CD8+ T cell activation by IL-2. J Immunol. 2013 Dec 1;191(11):5559-73
All references(153)
Other
accession IDs
MGD-MRK-13333, MGI:2139356, MGI:2442369

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory