Prkcq MGI Mouse Gene Detail - MGI:97601

Prkcq Gene Detail

Symbol

Prkcq
Name

protein kinase C, theta
Synonyms

A130035A12Rik, PKC-0, Pkcq, PKCtheta, PKC theta, PKC-theta

Feature Type

protein coding gene
IDs

MGI:97601
NCBI Gene: 18761
Gene Overview

MyGene.info: PRKCQ

Sequence Map

Chr2:11172108-11301222 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

129115 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 8.42 cM
Mapping Data

4 experiments

Human Ortholog

PRKCQ, protein kinase C theta

Vertebrate Orthologs

9

Human Ortholog

PRKCQ, protein kinase C theta
Orthology source: HomoloGene, HGNC
Synonyms

nPKC-theta, PRKCT
Links

HGNC:9410

NCBI Gene ID: 5588

neXtProt AC: NX_Q04759
Chr Location

10p15; chr10:6393595-6580646 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 21263
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish
HCOP

human homology predictions: PRKCQ
Protein SuperFamily

protein kinase C, delta/epsilon/eta/theta types
Gene Tree

Prkcq

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Phenotype Summary

37 phenotypes from 2 alleles in 5 genetic backgrounds
22 phenotypes from multigenic genotypes
77 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Incidental Mutations

Mutagenetix , APF

Homozygotes for targeted null mutations exhibit reduced T cell proliferative responses and interleukin 2 production and a lack of T cell receptor-initiated NF-kappaB activation in mature T lymphocytes.

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All GO Annotations

52
GO References

19

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

126
Tissues

58
cDNA Data

37
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase prkcq

ZFIN prkcq

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Prkcq interacts with 239 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

47
RefSeq

8
UniProt

7
CCDS

CCDS15682.1
UniGene

329993

			Length	Strain/Species	Flank
genomic	OTTMUSG00000011317	VEGA Gene Model \| MGI Sequence Detail	129115	C57BL/6J	± kb
transcript	OTTMUST00000026520	VEGA \| MGI Sequence Detail	3583	Not Applicable
polypeptide	OTTMUSP00000012133	VEGA \| MGI Sequence Detail	707	Not Applicable

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SNPs within 2kb

438 from dbSNP Build 142

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UniProt

7 Sequences
Protein Ontology

PR:000002344 protein kinase C theta type
PDB

4FKD
EC

2.7.11.13
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR000008 C2 domain

IPR020454 Diacylglycerol/phorbol-ester binding

IPR017441 Protein kinase, ATP binding site

IPR014376 Protein kinase C, delta/epsilon/eta/theta types

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR017892 Protein kinase, C-terminal

IPR027264 Protein kinase C, theta

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 39

cDNA 37

Primer pair 2

Microarray probesets 4

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MGD-MRK-13333, MGI:2139356, MGI:2442369

Summaries

All 154

Developmental Gene Expression 13

Gene Ontology 19

Phenotypes 77
Earliest

J:13213 Osada S, et al., A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992 Sep;12(9):3930-8
Latest

J:233781 Wang XD, et al., TCR-induced sumoylation of the kinase PKC-theta controls T cell synapse organization and T cell activation. Nat Immunol. 2015 Nov;16(11):1195-203

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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