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Prkce
Gene Detail
Symbol

Name
ID
Prkce
protein kinase C, epsilon
MGI:97599
Synonyms
5830406C15Rik, Pkce, PKC[e], PKCepsilon
Feature Type
protein coding gene
Genetic Map
Chromosome 17
56.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:86167785-86657919 bp, + strand
From VEGA annotation of GRCm38

  490135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48343  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PRKCE
Protein SuperFamily: protein kinase C, delta/epsilon/eta/theta types
Gene Tree: Prkce

Human
homologs
PRKCE, protein kinase C, epsilon
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5581
neXtProt AC: NX_Q02156

Human Synonyms: nPKC-epsilon, PKCE

Human Chr (Location): 2p21; chr2:45651315-46187990 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit reduced ethanol self-administration and are more sensitive to the acute behavioral effects of ethanol and other drugs that activate GABA(A) receptors. Mutants show reduced anxiety and stress hormones.
 
Interactions
Prkce interacts with 375 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (90 annotations)
Process cell adhesion, cell cycle, ...
Component cell, cell periphery, ...
Function 14-3-3 protein binding, actin monomer binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (184)    Tissues (43)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 164
Western blot 20
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkce ; ZFIN prkcea    NEW 
Molecular
reagents
All nucleic(52) cDNA(51) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017512 (Evidence)
Ensembl Gene Model ENSMUSG00000045038 (Evidence)
Entrez Gene 18754 (Evidence)
UniGene 24614
DFCI TC1588160, TC1602627, TC1694358
DoTS DT.87068598, DT.91334334
NIA Mouse Gene Index U043630, U260054
EC 2.7.11.13
Consensus CDS Project CCDS29008.1
International Mouse Phenotyping Consortium Status Prkce
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017512 VEGA Gene Model | MGI Sequence Detail 490135 C57BL/6J ±  kb
transcript OTTMUST00000042540 VEGA | MGI Sequence Detail 6254 Not Applicable 
polypeptide OTTMUSP00000019117 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(5811 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR014376 Protein kinase C, delta/epsilon/eta/theta types
InterPro IPR027274 Protein kinase C, epsilon
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000002342 protein kinase C epsilon
References
(Earliest) J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
(Latest) J:221819 Liu Y, et al., Genetic inhibition of protein kinase Cepsilon attenuates necrosis in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G550-63
All references(161)
Other
accession IDs
MGD-MRK-13331, MGI:1914847, MGI:2147156

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory