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Prkce Gene Detail
Summary
  • Symbol
    Prkce
  • Name
    protein kinase C, epsilon
  • Synonyms
    5830406C15Rik, Pkce, PKC[e], PKCepsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:97599
    NCBI Gene: 18754
Location & Maps
more
  • Sequence Map
    Chr17:86167785-86657919 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      490135 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRKCE, protein kinase C epsilon
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRKCE, protein kinase C epsilon
    Orthology source: HomoloGene
  • Synonyms
    nPKC-epsilon, PKCE
  • Links
    NCBI Gene ID: 5581
    neXtProt AC: NX_Q02156

  • Chr Location
    2p21; chr2:45651315-46187990 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    2
  • Targeted
    6
  • Transgenic
    2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit reduced ethanol self-administration and are more sensitive to the acute behavioral effects of ethanol and other drugs that activate GABA(A) receptors. Mutants show reduced anxiety and stress hormones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017512 VEGA Gene Model | MGI Sequence Detail 490135 C57BL/6J ±  kb
transcript OTTMUST00000042540 VEGA | MGI Sequence Detail 6254 Not Applicable  
polypeptide OTTMUSP00000019117 VEGA | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5811 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002342 protein kinase C epsilon
  • EC
  • InterPro Domains
    IPR000961 AGC-kinase, C-terminal
    IPR000008 C2 domain
    IPR020454 Diacylglycerol/phorbol-ester binding
    IPR017441 Protein kinase, ATP binding site
    IPR014376 Protein kinase C, delta/epsilon/eta/theta types
    IPR027274 Protein kinase C, epsilon
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR017892 Protein kinase, C-terminal
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 52
    cDNA 51
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-13331, MGI:1914847, MGI:2147156
References
more
  • Summaries
    All 163
    Developmental Gene Expression 19
    Gene Ontology 35
    Phenotypes 71
  • Earliest
    J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory