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Prkcg
Gene Detail
Symbol

Name
ID
Prkcg
protein kinase C, gamma
MGI:97597
Synonyms
Pkcc, PKCgamma, Prkcc
Feature Type
protein coding gene
Genetic Map
Chromosome 7
1.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr7:3303532-3331094 bp, + strand
From Ensembl annotation of GRCm38

  27563 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20602  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 2 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKCG
Protein SuperFamily: protein kinase C, alpha/beta/gamma types
Gene Tree: Prkcg

Human
homologs
PRKCG, protein kinase C, gamma
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5582
neXtProt AC: NX_P05129

Human Synonyms: PKCC, PKCG, PKC-gamma, SCA14

Human Chr (Location): 19q13.4; chr19:53882213-53907652 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRKCG

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident.
 
Interactions
Prkcg interacts with 136 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process chemosensory behavior, innervation, ...
Component cell-cell junction, cell junction, ...
Function ATP binding, calcium-dependent protein kinase C activity, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (140)    Tissues (68)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 2
Western blot 18
RT-PCR 115
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkcg ; ZFIN prkcg    NEW 
Molecular
reagents
All nucleic(35) Genomic(3) cDNA(27) Primer pair(4) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000078816 (Evidence)
Entrez Gene 18752 (Evidence)
UniGene 7980
DFCI TC1586719, TC1662235, TC1769319
DoTS DT.111203025, DT.87068447
NIA Mouse Gene Index U219120
EC 2.7.11.13
Consensus CDS Project CCDS57470.1
International Mouse Phenotyping Consortium Status Prkcg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078816 Ensembl Gene Model | MGI Sequence Detail 27563 C57BL/6J ±  kb
transcript ENSMUST00000100301 Ensembl | MGI Sequence Detail 3112 Not Applicable 
polypeptide ENSMUSP00000097874 Ensembl | MGI Sequence Detail 697 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(7) : SNPs within 2kb(171 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR014375 Protein kinase C, alpha/beta/gamma types
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003060 protein kinase C gamma type
References
(Earliest) J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
(Latest) J:221589 Szabo NE, et al., Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception. J Neurosci. 2015 Apr 1;35(13):5233-46
All references(154)
Other
accession IDs
MGD-MRK-13329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory