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Prkcg Gene Detail
Summary
  • Symbol
    Prkcg
  • Name
    protein kinase C, gamma
  • Synonyms
    Pkcc, PKCgamma, Prkcc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97597
    NCBI Gene: 18752
Location & Maps
more
Homology
more
  • Human Ortholog
    PRKCG, protein kinase C gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKCG, protein kinase C gamma
    Orthology source: HomoloGene
  • Synonyms
    PKCC, PKCG, PKC-gamma, SCA14
  • Links
    NCBI Gene ID: 5582
    neXtProt AC: NX_P05129

  • Chr Location
    19q13.4; chr19:53882213-53907652 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PRKCG associations

Human Disease Mouse Models
       Spinocerebellar Ataxia 14; SCA14   OMIM: 605361 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18752 NCBI Gene Model | MGI Sequence Detail 27568 C57BL/6J ±  kb
transcript NM_011102 RefSeq | MGI Sequence Detail 3131 C57BL/6  
polypeptide P63318 UniProt | EBI | MGI Sequence Detail 697 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    171 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003060 protein kinase C gamma type
  • EC
  • InterPro Domains
    IPR000961 AGC-kinase, C-terminal
    IPR000008 C2 domain
    IPR020454 Diacylglycerol/phorbol-ester binding
    IPR017441 Protein kinase, ATP binding site
    IPR014375 Protein kinase C, alpha/beta/gamma types
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR017892 Protein kinase, C-terminal
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 35
    Genomic 3
    cDNA 27
    Primer pair 4
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-13329
References
more
  • Summaries
    All 153
    Developmental Gene Expression 42
    Diseases 1
    Gene Ontology 19
    Phenotypes 38
  • Earliest
    J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
  • Latest
    J:221589 Szabo NE, et al., Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception. J Neurosci. 2015 Apr 1;35(13):5233-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory