Prkcg
Gene Detail

Symbol Name ID

Prkcg protein kinase C, gamma MGI:97597

Synonyms

Pkcc, PKCgamma, Prkcc

Feature Type

protein coding gene

Genetic Map

Chromosome 7

1.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)

Sequence Map

Chr7:3303532-3330696 bp, + strand From NCBI annotation of GRCm38   27165 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20602  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 dog; 1 zebrafish

Protein SuperFamily: protein kinase C, alpha/beta/gamma types
Gene Tree: Prkcg

Human homologs

Human Homolog		PRKCG, protein kinase C, gamma
NCBI Gene ID		5582
neXtProt AC		NX_P05129
Human Synonyms		PKCC, PKCG, PKC-gamma, SCA14
Human Chr (Location)		19q13.4; chr19:53882213-53907647 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human PRKCG

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	chemosensory behavior, innervation, ...
Component	cell-cell junction, cell junction, ...
Function	ATP binding, calcium-dependent protein kinase C activity, ...

External Resources: FuncBase

Expression

Literature Summary: (37 records)

Data Summary: Results (148)    Tissues (66)    Images (18)
Theiler Stages: 2, 3, 5, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	2
Western blot	22
RT-PCR	119

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) Genomic(3) cDNA(27) Primer pair(4) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000078816 (Evidence)
Entrez Gene	18752 (Evidence)
UniGene	7980
DFCI	TC1586719, TC1662235, TC1769319
DoTS	DT.111203025, DT.87068447
NIA Mouse Gene Index	U219120
EC	2.7.11.13
Consensus CDS Project	CCDS57470.1
International Mouse Knockout Project Status	Prkcg

Sequences

Length	Strain/Species
genomic	18752	NCBI Gene Model | MGI Sequence Detail	27165	C57BL/6J
transcript	NM_011102	RefSeq | MGI Sequence Detail	2715	C57BL/6
polypeptide	P63318	UniProt | EBI | MGI Sequence Detail	697	Not Applicable

All sequences(32) RefSeq(10) UniProt(3)

Polymorphisms

RFLP(7) : SNPs within 2kb(170 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR014375	Protein kinase C, alpha/beta/gamma types
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003060	protein kinase C gamma type

Graphical View of Protein Domain Structure

References

(Earliest) J:12309 Yang-Feng TL, et al., Protein kinase C genes in the mouse: Pkca maps to MMU 11 and Pkcc to MMU7. Cytogenet Cell Genet. 1987;46:723
(Latest) J:205968 Buitrago L, et al., Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms. J Biol Chem. 2013 Oct 4;288(40):29160-9
All references(147)

Other accession IDs

MGD-MRK-13329