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Prkcg Gene Detail
Summary
  • Symbol
    Prkcg
  • Name
    protein kinase C, gamma
  • Synonyms
    Pkcc, PKCgamma, Prkcc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97597
    NCBI Gene: 18752
  • Gene Overview
    MyGene.info: PRKCG
  • Alliance
    gene page
Location & Maps
more
  • Genetic Map
    Chromosome 7, 1.93 cM
  • Mapping Data
    31 experiments
Homology
more
  • Human Ortholog
    PRKCG, protein kinase C gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKCG, protein kinase C gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PKCC, PKCG, PKCgamma, PKC-gamma, PKCI(3), SCA14
  • Links
    NCBI Gene ID: 5582
    neXtProt AC: NX_P05129
    UniProt: P05129

  • Chr Location
    19q13.42; chr19:53882184-53907647 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human PRKCG associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    61
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    141
  • Tissues
    69
  • cDNA Data
    25
  • Literature Summary
    50
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057714 VEGA Gene Model | MGI Sequence Detail 41921 C57BL/6J ±  kb
transcript OTTMUST00000141777 VEGA | MGI Sequence Detail 3127 Not Applicable  
polypeptide OTTMUSP00000074027 VEGA | MGI Sequence Detail 697 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    286 from dbSNP Build 142
  • RFLP
    7
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    Genomic 3
    cDNA 28
    Primer pair 4
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-13329
References
more
  • Summaries
    All 178
    Developmental Gene Expression 50
    Diseases 1
    Gene Ontology 21
    Phenotypes 46
  • Earliest
    J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
  • Latest
    J:264523 Colgan LA, et al., PKCalpha integrates spatiotemporally distinct Ca(2+) and autocrine BDNF signaling to facilitate synaptic plasticity. Nat Neurosci. 2018 Aug;21(8):1027-1037
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/16/2018
MGI 6.12 		The Jackson Laboratory