Prkcg
Gene Detail

Symbol

Name
ID

Prkcg
protein kinase C, gamma
MGI:97597

Synonyms

Pkcc, PKCgamma, Prkcc

Feature Type

protein coding gene

Genetic Map

Chromosome 7
1.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)

Sequence Map

Chr7:3303532-3331094 bp, + strand From Ensembl annotation of GRCm38   27563 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20602  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 2 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein kinase C, alpha/beta/gamma types
Gene Tree: Prkcg

Human
homologs

Human Homolog		PRKCG, protein kinase C, gamma
NCBI Gene ID		5582
neXtProt AC		NX_P05129
Human Synonyms		PKCC, PKCG, PKC-gamma, SCA14
Human Chr (Location)		19q13.4; chr19:53882213-53907647 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human PRKCG

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident.

 

Interactions

Prkcg interacts with 136 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (48 annotations)

Process	chemosensory behavior, innervation, ...
Component	cell-cell junction, cell junction, ...
Function	ATP binding, calcium-dependent protein kinase C activity, ...

External Resources: FuncBase

Expression

Literature Summary: (41 records)

Data Summary: Results (140)    Tissues (68)    Images (18)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	5
RNA in situ	2
Western blot	18
RT-PCR	115

cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(35) Genomic(3) cDNA(27) Primer pair(4) Other(1)
Microarray probesets(2)

Other database
links

Ensembl Gene Model	ENSMUSG00000078816 (Evidence)
Entrez Gene	18752 (Evidence)
UniGene	7980
DFCI	TC1586719, TC1662235, TC1769319
DoTS	DT.111203025, DT.87068447
NIA Mouse Gene Index	U219120
EC	2.7.11.13
Consensus CDS Project	CCDS57470.1
International Mouse Knockout Project Status	Prkcg

Sequences

Length	Strain/Species
genomic	ENSMUSG00000078816	Ensembl Gene Model | MGI Sequence Detail	27563	C57BL/6J
transcript	ENSMUST00000100301	Ensembl | MGI Sequence Detail	3112	Not Applicable
polypeptide	ENSMUSP00000097874	Ensembl | MGI Sequence Detail	697	Not Applicable

All sequences(33) RefSeq(8) UniProt(5)

Polymorphisms

RFLP(7) : SNPs within 2kb(171 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR014375	Protein kinase C, alpha/beta/gamma types
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003060	protein kinase C gamma type

References

(Earliest) J:12309 Yang-Feng TL, et al., Protein kinase C genes in the mouse: Pkca maps to MMU 11 and Pkcc to MMU7. Cytogenet Cell Genet. 1987;46:723
(Latest) J:215306 Shirafuji T, et al., The role of Pak-interacting exchange factor-beta phosphorylation at serines 340 and 583 by PKCgamma in dopamine release. J Neurosci. 2014 Jul 9;34(28):9268-80
All references(156)

Other
accession IDs

MGD-MRK-13329