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Prkcg Gene Detail
Summary
  • Symbol
    Prkcg
  • Name
    protein kinase C, gamma
  • Synonyms
    Pkcc, PKCgamma, Prkcc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97597
    NCBI Gene: 18752
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:3351982-3379615 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 1.93 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97597
 protein coding gene Chr7:3337704-3379615 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031516
 protein coding gene Chr7:187054-233297 (+)
A/J MGP_AJ_G0031491
 protein coding gene Chr7:196944-238862 (+)
AKR/J MGP_AKRJ_G0031419
 protein coding gene Chr7:188588-230546 (+)
BALB/cJ MGP_BALBcJ_G0031499
 protein coding gene Chr7:194532-237383 (+)
C3H/HeJ MGP_C3HHeJ_G0031219
 protein coding gene Chr7:190307-234073 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031959
 protein coding gene Chr7:193717-236931 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029086
 protein coding gene Chr7:94056-137037 (+)
CAST/EiJ MGP_CASTEiJ_G0030588
 protein coding gene Chr7:194408-239155 (+)
CBA/J MGP_CBAJ_G0031179
 protein coding gene Chr7:267484-322766 (+)
DBA/2J MGP_DBA2J_G0031336
 protein coding gene Chr7:181780-228441 (+)
FVB/NJ MGP_FVBNJ_G0031288
 protein coding gene Chr7:186372-230158 (+)
LP/J MGP_LPJ_G0031421
 protein coding gene Chr7:186652-232418 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031327
 protein coding gene Chr7:213361-256251 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031993
 protein coding gene Chr7:166740-209767 (+)
PWK/PhJ MGP_PWKPhJ_G0030315
 protein coding gene Chr7:328254-370962 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030139
 protein coding gene Chr7:259292-305076 (+)
WSB/EiJ MGP_WSBEiJ_G0030682
 protein coding gene Chr7:180965-226813 (+)



Homology
more
  • Human Ortholog
    PRKCG, protein kinase C gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKCG, protein kinase C gamma
  • Synonyms
    PKCC, PKCG, PKCgamma, PKC-gamma, PKCI(3), SCA14
  • Links
    NCBI Gene ID: 5582
    neXtProt AC: NX_P05129
    UniProt: P05129

  • Chr Location
    19q13.42; chr19:53882184-53907647 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Prkcg mouse models; 1 with human PRKCG associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 9 genetic backgrounds
    6 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    80
  • cDNA Data
    25
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18752 NCBI Gene Model | MGI Sequence Detail 27634 C57BL/6J ±  kb
    transcript NM_011102 RefSeq | MGI Sequence Detail 3131 C57BL/6  
    polypeptide P63318 UniProt | EBI | MGI Sequence Detail 697 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 3
      cDNA 28
      Primer pair 4
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-13329
    References
    more
    • Summaries
      All 197
      Developmental Gene Expression 57
      Diseases 2
      Gene Ontology 20
      Phenotypes 56
    • Earliest
      J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
    • Latest
      J:314906 Khang R, et al., Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Sci Rep. 2021 Nov 23;11(1):22745
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/22/2022
    MGI 6.22     		The Jackson Laboratory