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Prkcg
Gene Detail
 Symbol
Name
ID
Prkcg
protein kinase C, gamma
MGI:97597
Synonyms Pkcc, PKCgamma, Prkcc
Feature Type protein coding gene
Genetic Map
Chromosome 7
1.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr7:3303532-3330696 bp, + strand
From NCBI annotation of GRCm38

  27165 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20602  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 dog; 1 zebrafish

Protein SuperFamily: protein kinase C, alpha/beta/gamma types
Gene Tree: Prkcg

Human
homologs
Human Homolog PRKCG, protein kinase C, gamma
NCBI Gene ID 5582
neXtProt AC  NX_P05129
Human Synonyms  PKCC, PKCG, PKC-gamma, SCA14
Human Chr (Location)  19q13.4; chr19:53882213-53907647 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRKCG
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident.
 
Interactions
Prkcg interacts with 136 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process chemosensory behavior, innervation, ...
Component cell-cell junction, cell junction, ...
Function ATP binding, calcium-dependent protein kinase C activity, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (148)    Tissues (66)    Images (18)
Theiler Stages: 2, 3, 5, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 2
Western blot 22
RT-PCR 119
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(3) cDNA(27) Primer pair(4) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000078816 (Evidence)
Entrez Gene18752 (Evidence)
UniGene7980
DFCITC1586719, TC1662235, TC1769319
DoTSDT.111203025, DT.87068447
NIA Mouse Gene IndexU219120
EC2.7.11.13
Consensus CDS ProjectCCDS57470.1
International Mouse Knockout Project StatusPrkcg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18752 NCBI Gene Model | MGI Sequence Detail 27165 C57BL/6J ±  kb
transcript NM_011102 RefSeq | MGI Sequence Detail 3131 C57BL/6 
polypeptide P63318 UniProt | EBI | MGI Sequence Detail 697 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(3)
Polymorphisms RFLP(7) : SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR014375 Protein kinase C, alpha/beta/gamma types
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003060 protein kinase C gamma type
Graphical View of Protein Domain Structure
References (Earliest) J:12309 Yang-Feng TL, et al., Protein kinase C genes in the mouse: Pkca maps to MMU 11 and Pkcc to MMU7. Cytogenet Cell Genet. 1987;46:723
(Latest) J:209809 Diehl SA, et al., G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun. 2014 Feb;82(2):773-82
All references(149)
Other
accession IDs
MGD-MRK-13329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory