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Phenotypes Associated with This Genotype
Genotype
MGI:6865691
Allelic
Composition		 Prkcgem1Jpka/Prkcg+
Genetic
Background		 FVB/N-Prkcgem1Jpka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcgem1Jpka mutation (0 available); any Prkcg mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:305637 )
• mice show marked ataxia at 3 and 6 months of age on the balance beam test
abnormal gait ( J:305637 )
• footprint gait analysis of 9-month-old mice shows an ataxic gait with increased step width

nervous system
abnormal Purkinje cell dendrite morphology ( J:305637 )
• dendritic expansion of Purkinje cells in organotypic slice culture is severely impaired and cells develop only short thickened dendrites

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
spinocerebellar ataxia 14 DOID:0050964 OMIM:605361
 J:305637

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory