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Pou1f1
Gene Detail
Symbol

Name
ID
Pou1f1
POU domain, class 1, transcription factor 1
MGI:97588
Synonyms
GHF-1, Hmp1, Pit1, Pit-1, Pit1-rs1, Snell dwarf
Feature Type
protein coding gene
Genetic Map
Chromosome 16
37.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr16:65520511-65534297 bp, + strand
From VEGA annotation of GRCm38

  13787 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:259  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POU1F1
Protein SuperFamily: transcription factor Pit-1
Gene Tree: Pou1f1

Human
homologs
POU1F1, POU class 1 homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5449
neXtProt AC: NX_P28069

Human Synonyms: CPHD1, GHF-1, Pit-1, PIT1, POU1F1a

Human Chr (Location): 3p11; chr3:87259633-87276587 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human POU1F1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(2) Targeted(3)
 
Homozygotes for spontaneous mutations exhibit hypoplasia of the anterior pituitary cells resulting in deficiencies in growth hormone, prolactin, and thyroid-stimulating hormone, dwarfism, and sterility.
 
Phenotype Images(1)
Interactions
Pou1f1 interacts with 83 markers (Mir7-2, Mir7b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process adenohypophysis development, B cell differentiation, ...
Component cytoplasm, nucleoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (154)    Tissues (134)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 148
RT-PCR 4
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN pou1f1    NEW 
Molecular
reagents
All nucleic(33) Genomic(2) cDNA(24) Primer pair(4) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000039845 (Evidence)
Ensembl Gene Model ENSMUSG00000004842 (Evidence)
Entrez Gene 18736 (Evidence)
UniGene 355440
DFCI TC1587096
DoTS DT.101350878, DT.55188964
NIA Mouse Gene Index U017249
Consensus CDS Project CCDS57033.1
International Mouse Phenotyping Consortium Status Pou1f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039845 VEGA Gene Model | MGI Sequence Detail 13787 C57BL/6J ±  kb
transcript OTTMUST00000103541 VEGA | MGI Sequence Detail 1174 Not Applicable 
polypeptide OTTMUSP00000057856 VEGA | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(4)
Polymorphisms
All PCR and RFLP(9) : PCR(2) RFLP(7) SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR015586 Pituitary-specific positive transcription factor 1
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013033 pituitary-specific positive transcription factor 1
References
(Earliest) J:13120 Snell GD, DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE. Proc Natl Acad Sci U S A. 1929 Sep 15;15(9):733-4
(Latest) J:220762 Dominick G, et al., Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice. Endocrinology. 2015 Feb;156(2):565-75
All references(229)
Other
accession IDs
MGD-MRK-13314, MGD-MRK-13315, MGD-MRK-19464, MGD-MRK-8920, MGI:102578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory