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Phkb Gene Detail
Summary
  • Symbol
    Phkb
  • Name
    phosphorylase kinase beta
  • Synonyms
    MGC:62514
  • Feature Type
    protein coding gene
  • IDs
    MGI:97578
    NCBI Gene: 102093
  • Gene Overview
    MyGene.info: PHKB
Location & Maps
more
  • Sequence Map
    Chr8:85840959-86061376 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      220418 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.61 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PHKB, phosphorylase kinase regulatory subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PHKB, phosphorylase kinase regulatory subunit beta
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5257
    neXtProt AC: NX_Q93100

  • Chr Location
    16q12.1; chr16:47461268-47701523 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PHKB associations

Human Disease Mouse Models
       Glycogen Storage Disease Ixb; GSD9B   OMIM: 261750
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotype references
  • All Mutations and Alleles
    17
  • Gene trapped
    14
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Phkb
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031187 VEGA Gene Model | MGI Sequence Detail 220418 C57BL/6J ±  kb
transcript OTTMUST00000077272 VEGA | MGI Sequence Detail 5351 Not Applicable  
polypeptide OTTMUSP00000040826 VEGA | MGI Sequence Detail 1085 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1334 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000012660 phosphorylase b kinase regulatory subunit beta
  • InterPro Domains
    IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family
    IPR008734 Phosphorylase kinase alpha/beta subunit
    IPR008928 Six-hairpin glycosidase-like
Molecular
Reagents
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  • All nucleic 90
    cDNA 90

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13297, MGI:2142562
References
more
  • Summaries
    All 37
    Gene Ontology 4
    Phenotypes 33
  • Earliest
    J:8697 Chamberlain JS, et al., Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice. Proc Natl Acad Sci U S A. 1987 May;84(9):2886-90
  • Latest
    J:186636 Arun G, et al., mrhl RNA, a Long Noncoding RNA, Negatively Regulates Wnt Signaling through Its Protein Partner Ddx5/p68 in Mouse Spermatogonial Cells. Mol Cell Biol. 2012 Aug;32(15):3140-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory