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Pgam1 Gene Detail
Summary
  • Symbol
    Pgam1
  • Name
    phosphoglycerate mutase 1
  • Synonyms
    2310050F24Rik, Pgam-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97552
    NCBI Gene: 18648
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41900362-41907099 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 35.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97552
protein coding gene Chr19:41900310-41907104 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025130
protein coding gene Chr19:41216044-41222004 (+)
A/J MGP_AJ_G0025107
protein coding gene Chr19:39232893-39239715 (+)
AKR/J MGP_AKRJ_G0025075
protein coding gene Chr19:40522542-40529157 (+)
BALB/cJ MGP_BALBcJ_G0025101
protein coding gene Chr19:39290162-39298609 (+)
C3H/HeJ MGP_C3HHeJ_G0024861
protein coding gene Chr19:40673402-40679358 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0022958
protein coding gene Chr19:38588902-38595647 (+)
CAST/EiJ MGP_CASTEiJ_G0024326
protein coding gene Chr19:40342279-40350556 (+)
CBA/J MGP_CBAJ_G0024841
protein coding gene Chr19:44348787-44359706 (+)
DBA/2J MGP_DBA2J_G0024973
protein coding gene Chr19:39083212-39090184 (+)
FVB/NJ MGP_FVBNJ_G0024934
protein coding gene Chr19:38856421-38863891 (+)
LP/J MGP_LPJ_G0025059
protein coding gene Chr19:41207661-41214127 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024965
protein coding gene Chr19:43975966-43984777 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025602
protein coding gene Chr19:40560992-40566991 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0023879
protein coding gene Chr19:39302270-39310131 (+)
WSB/EiJ MGP_WSBEiJ_G0024396
protein coding gene Chr19:40711504-40719023 (+)



Homology
more
  • Human Ortholog
    PGAM1, phosphoglycerate mutase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGAM1, phosphoglycerate mutase 1
  • Synonyms
    HEL-S-35, PGAMA, PGAM-B
  • Links
    NCBI Gene ID: 5223
    neXtProt AC: NX_P18669
    UniProt: P18669

  • Chr Location
    10q24.1; chr10:97426125-97433444 (+)  GRCh38.p7

  • Human Ortholog
    PGAM4, phosphoglycerate mutase family member 4
  • Synonyms
    dJ1000K24.1, PGAM1, PGAM3, PGAM-B
  • Links
    NCBI Gene ID: 441531
    neXtProt AC: NX_Q8N0Y7
    UniProt: Q8N0Y7

  • Chr Location
    Xq21.1; chrX:77967961-77969638 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Knock-out of this gene results in embryonic lethality before E13.5. T cell-specific knock-out affects glycolysis, which causes a reduced T cell inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000011752 Ensembl Gene Model | MGI Sequence Detail 6738 C57BL/6J ±  kb
transcript ENSMUST00000011896 Ensembl | MGI Sequence Detail 1775 Not Applicable  
polypeptide ENSMUSP00000011896 Ensembl | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 600
    cDNA 596
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13253, MGD-MRK-13254, MGI:1915256
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:4443 Fundele R, et al., Enzyme patterns in trisomy 19 of the mouse. Dev Genet. 1981;2:291-303
  • Latest
    J:307317 Mikawa T, et al., Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis. PLoS One. 2021;16(4):e0250856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory