About   Help   FAQ
Pgam1 Gene Detail
Summary
  • Symbol
    Pgam1
  • Name
    phosphoglycerate mutase 1
  • Synonyms
    2310050F24Rik, Pgam-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97552
    NCBI Gene: 18648
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41900362-41907099 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 35.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    38
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97552
 protein coding gene Chr19:41900310-41907104 (+)
129S1/SvImJ ENSMUSG00200025847
 protein coding gene Chr19:38632553-38639300 (+)
129S1/SvImJ ENSMUSG00200000559
 protein coding gene Chr3:7780300-7781978 (-)
A/J ENSMUSG00195010150
 protein coding gene Chr19:38737244-38743992 (+)
A/J ENSMUSG00195047829
 protein coding gene Chr7:19618050-19619910 (-)
AKR/J ENSMUSG00220017020
 protein coding gene Chr3:7953633-7955311 (-)
AKR/J ENSMUSG00220017904
 protein coding gene Chr19:38549341-38556088 (+)
AKR/J ENSMUSG00220043251
 protein coding gene Chr7:24866113-24867904 (+)
BALB/cJ ENSMUSG00180007082
 protein coding gene Chr3:8116657-8118335 (-)
BALB/cJ ENSMUSG00180028180
 protein coding gene Chr19:38989669-38996417 (+)
BALB/cJ ENSMUSG00180053285
 protein coding gene Chr7:17683230-17685081 (-)
C3H/HeJ ENSMUSG00175038006
 protein coding gene Chr19:38511553-38518300 (+)
C3H/HeJ ENSMUSG00175050335
 protein coding gene Chr7:18727588-18729369 (-)
C3H/HeJ ENSMUSG00175005024
 protein coding gene Chr3:8102935-8104613 (-)
C57BL/6NJ ENSMUSG00215023006
 protein coding gene Chr19:38589856-38596593 (+)
C57BL/6NJ ENSMUSG00215005103
 protein coding gene Chr3:8113061-8114739 (-)
C57BL/6NJ ENSMUSG00215053488
 protein coding gene Chr7:16857455-16859407 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022958
 protein coding gene Chr19:38588902-38595647 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210030597
 protein coding gene Chr19:38593681-38600428 (+)
CBA/J ENSMUSG00210052853
 protein coding gene Chr7:17912204-17913985 (-)
CBA/J ENSMUSG00210000486
 protein coding gene Chr3:8088047-8089725 (-)
DBA/2J ENSMUSG00185048897
 protein coding gene Chr7:21019180-21020953 (-)
DBA/2J ENSMUSG00185000480
 protein coding gene Chr3:8095278-8096956 (-)
DBA/2J ENSMUSG00185032171
 protein coding gene Chr19:39113854-39120601 (+)
FVB/NJ ENSMUSG00205005887
 protein coding gene Chr3:7868238-7869916 (-)
FVB/NJ ENSMUSG00205006283
 protein coding gene Chr19:38064401-38071148 (+)
FVB/NJ ENSMUSG00205033260
 protein coding gene Chr7:17701633-17703406 (-)
JF1/MsJ ENSUMUG00000044617
 protein coding gene Chr19:39278316-39285016 (+)
LP/J ENSMUSG00230033827
 protein coding gene Chr19:39902649-39909396 (+)
LP/J ENSMUSG00230004252
 protein coding gene Chr3:10013192-10014870 (-)
NOD/ShiLtJ ENSMUSG00190010946
 protein coding gene Chr19:38463661-38470408 (+)
NOD/ShiLtJ ENSMUSG00190050541
 protein coding gene Chr7:17353413-17355234 (-)
NOD/ShiLtJ ENSMUSG00190022717
 protein coding gene Chr3:8200376-8202054 (-)
NZO/HlLtJ ENSMUSG00225025637
 protein coding gene Chr7:25067891-25069787 (-)
NZO/HlLtJ ENSMUSG00225041646
 protein coding gene Chr19:43460690-43467437 (+)
NZO/HlLtJ ENSMUSG00225000712
 protein coding gene Chr3:12593707-12595385 (-)
PWK/PhJ ENSLUMG00010001001
 protein coding gene Chr19:38446644-38453364 (+)
SPRET/EiJ ENSMSPG00010018792
 protein coding gene Chr19:38179083-38186013 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PGAM1, phosphoglycerate mutase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGAM1, phosphoglycerate mutase 1
  • Synonyms
    HEL-S-35, PGAMA, PGAM-B
  • Links
    NCBI Gene ID: 5223
    UniProt: P18669

  • Chr Location
    10q24.1; chr10:97426124-97433444 (+)  GRCh38
  • Human Ortholog
    PGAM4, phosphoglycerate mutase family member 4
  • Synonyms
    dJ1000K24.1, PGAM1, PGAM3, PGAM-B
  • Links
    NCBI Gene ID: 441531
    UniProt: Q8N0Y7

  • Chr Location
    Xq21.1; chrX:77967949-77969638 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-out of this gene results in embryonic lethality before E13.5. T cell-specific knock-out affects glycolysis, which causes a reduced T cell inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    130
  • cDNA Data
    596
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000011752 Ensembl Gene Model | MGI Sequence Detail 6738 C57BL/6J ±  kb
transcript ENSMUST00000011896 Ensembl | MGI Sequence Detail 1775 Not Applicable  
polypeptide ENSMUSP00000011896 Ensembl | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 600
    cDNA 596
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13253, MGD-MRK-13254, MGI:1915256
References
more
  • Summaries
    All 63
    Developmental Gene Expression 7
    Gene Ontology 15
    Phenotypes 12
  • Earliest
    J:4443 Fundele R, et al., Enzyme patterns in trisomy 19 of the mouse. Dev Genet. 1981;2(3):291-303
  • Latest
    J:375845 Watanuki S, et al., SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production. Cell Stem Cell. 2024 May 14;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory