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Pfkl
Gene Detail
Symbol

Name
ID
Pfkl
phosphofructokinase, liver, B-type
MGI:97547
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr10:77986947-78010083 bp, - strand
From VEGA annotation of GRCm38

  23137 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55668  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PFKL
Protein SuperFamily: ATP-dependent phosphofructokinase, eukaryotic type
Gene Tree: Pfkl

Human
homologs
PFKL, phosphofructokinase, liver
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5211
neXtProt AC: NX_P17858

Human Synonyms: ATP-PFK, PFK-B, PFK-L

Human Chr (Location): 21q22.3; chr21:44300034-44327381 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(5) Transgenic(1)
Genomic Mutations involving Pfkl (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Mutations Annotated to Human Diseases (1)   
Interactions
Pfkl interacts with 160 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process carbohydrate metabolic process, carbohydrate phosphorylation, ...
Component 6-phosphofructokinase complex, cytoplasm, ...
Function 6-phosphofructokinase activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (486)    Tissues (162)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 470
RT-PCR 16
cDNA source data(342)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN pfklb    NEW 
Molecular
reagents
All nucleic(364) Genomic(16) cDNA(346) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016976 (Evidence)
Ensembl Gene Model ENSMUSG00000020277 (Evidence)
Entrez Gene 18641 (Evidence)
UniGene 269649
DFCI TC1573996, TC1597991, TC1621201
NIA Mouse Gene Index U031964
EC 2.7.1.11
Consensus CDS Project CCDS35955.1
International Mouse Phenotyping Consortium Status Pfkl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016976 VEGA Gene Model | MGI Sequence Detail 23137 C57BL/6J ±  kb
transcript OTTMUST00000041169 VEGA | MGI Sequence Detail 3730 Not Applicable 
polypeptide OTTMUSP00000018445 VEGA | MGI Sequence Detail 780 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(5) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022953 ATP-dependent 6-phosphofructokinase
InterPro IPR009161 ATP-dependent 6-phosphofructokinase, eukaryotic-type
InterPro IPR015912 Phosphofructokinase, conserved site
InterPro IPR000023 Phosphofructokinase domain
Protein Ontology PR:000012582 6-phosphofructokinase, liver type
References
(Earliest) J:223061 Marcus F, et al., Mouse (C57BL/KsJ) liver phosphofructokinase. Allosteric kinetics and age-related changes in the genetically diabetic state. J Biol Chem. 1981 Jan 10;256(1):378-81
(Latest) J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540
All references(59)
Other
accession IDs
MGD-MRK-13246, MGI:2143459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory