Pfkl
Gene Detail

Symbol Name ID

Pfkl phosphofructokinase, liver, B-type MGI:97547

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr10:77986947-78010083 bp, - strand From VEGA annotation of GRCm38   23137 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55668  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ATP-dependent phosphofructokinase, eukaryotic type
Gene Tree: Pfkl

Human homologs

Human Homolog		PFKL, phosphofructokinase, liver
NCBI Gene ID		5211
neXtProt AC		NX_P17858
Human Synonyms		PFK-B
Human Chr (Location)		21q22.3; chr21:45719925-45747261 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(2) Gene trapped(8)

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	carbohydrate metabolic process, carbohydrate phosphorylation, ...
Component	6-phosphofructokinase complex, cytoplasm, ...
Function	6-phosphofructokinase activity, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (486)    Tissues (162)    Images (62)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	470
RT-PCR	16

cDNA source data(342)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(364) Genomic(16) cDNA(346) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016976 (Evidence)
Ensembl Gene Model	ENSMUSG00000020277 (Evidence)
Entrez Gene	18641 (Evidence)
UniGene	269649
DFCI	TC1573996, TC1597991, TC1621201
NIA Mouse Gene Index	U031964
EC	2.7.1.11
Consensus CDS Project	CCDS35955.1
International Mouse Knockout Project Status	Pfkl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016976	VEGA Gene Model | MGI Sequence Detail	23137	C57BL/6J
transcript	OTTMUST00000041169	VEGA | MGI Sequence Detail	3730	Not Applicable
polypeptide	OTTMUSP00000018445	VEGA | MGI Sequence Detail	780	Not Applicable

All sequences(52) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(5) : SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009161	6-phosphofructokinase, eukaryotic type
InterPro	IPR022953	Phosphofructokinase
InterPro	IPR015912	Phosphofructokinase, conserved site
InterPro	IPR000023	Phosphofructokinase domain
Protein Ontology	PR:000012582	6-phosphofructokinase, liver type

References

(Earliest) J:19330 Gehnrich SC, et al., Liver (B-type) phosphofructokinase mRNA. Cloning, structure, and expression. J Biol Chem. 1988 Aug 25;263(24):11755-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(63)

Other accession IDs

MGD-MRK-13246, MGI:2143459