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Pepd
Gene Detail
Symbol

Name
ID
Pepd
peptidase D
MGI:97542
Synonyms
dal, Pep4, Pep-4, peptidase D
Feature Type
protein coding gene
Genetic Map
Chromosome 7
20.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr7:34912379-35044710 bp, + strand
From VEGA annotation of GRCm38

  132332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:239  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PEPD
Protein SuperFamily: aminopeptidase P
Gene Tree: Pepd

Human
homologs
PEPD, peptidase D
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5184
neXtProt AC: NX_P12955

Human Synonyms: PROLIDASE

Human Chr (Location): 19q13.11; chr19:33386949-33521893 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PEPD

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(11) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants are smaller than normal siblings and, except on the flanks, an agouti coat appears nonagouti.
 
Human Diseases Modeled in Mice Using Pepd (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Pepd interacts with 70 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process collagen catabolic process, proteolysis
Component extracellular exosome
Function aminopeptidase activity, dipeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (196)    Tissues (99)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 150
RT-PCR 46
cDNA source data(107)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pepd    NEW 
Molecular
reagents
All nucleic(109) Genomic(1) cDNA(107) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031826 (Evidence)
Ensembl Gene Model ENSMUSG00000063931 (Evidence)
Entrez Gene 18624 (Evidence)
UniGene 69751
DFCI TC1575243
DoTS DT.490627
NIA Mouse Gene Index U007964
EC 3.4.13.9
Consensus CDS Project CCDS21143.1
International Mouse Phenotyping Consortium Status Pepd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031826 VEGA Gene Model | MGI Sequence Detail 132332 C57BL/6J ±  kb
transcript OTTMUST00000078912 VEGA | MGI Sequence Detail 1883 Not Applicable 
polypeptide OTTMUSP00000042019 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(1615 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1619)
Protein-related
information
ResourceIDDescription
InterPro IPR007865 Aminopeptidase P N-terminal domain
InterPro IPR001131 Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
InterPro IPR000994 Peptidase M24, structural domain
Protein Ontology PR:000012546 Xaa-Pro dipeptidase
References
(Earliest) J:5133 Lewis WH, et al., Electrophoretic heterogeneity of mouse erythrocyte peptidases. Biochem Genet. 1969 Oct;3(5):493-8
(Latest) J:217456 Besio R, et al., Lack of prolidase causes a bone phenotype both in human and in mouse. Bone. 2015 Mar;72:53-64
All references(57)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13234, MGD-MRK-13239, MGI:1934634

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory