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Pepd Gene Detail
Summary
  • Symbol
    Pepd
  • Name
    peptidase D
  • Synonyms
    dal, Pep4, Pep-4, peptidase D
  • Feature Type
    protein coding gene
  • IDs
    MGI:97542
    NCBI Gene: 18624
  • Gene Overview
    MyGene.info: PEPD
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:34912407-35044708 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 20.70 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1605 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97542
protein coding gene Chr7:34912379-35044708 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032080
protein coding gene Chr7:34259462-34393488 (+)
A/J MGP_AJ_G0032060
protein coding gene Chr7:33358269-33490815 (+)
AKR/J MGP_AKRJ_G0031993
protein coding gene Chr7:34155784-34293420 (+)
BALB/cJ MGP_BALBcJ_G0032067
protein coding gene Chr7:33653321-33787417 (+)
C3H/HeJ MGP_C3HHeJ_G0031784
protein coding gene Chr7:35051659-35187996 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032544
protein coding gene Chr7:35957356-36097533 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029577
protein coding gene Chr7:34080229-34213956 (+)
CAST/EiJ MGP_CASTEiJ_G0031119
protein coding gene Chr7:26187360-26325131 (+)
CBA/J MGP_CBAJ_G0031752
protein coding gene Chr7:37082812-37232680 (+)
DBA/2J MGP_DBA2J_G0031904
protein coding gene Chr7:33201453-33335055 (+)
FVB/NJ MGP_FVBNJ_G0031859
protein coding gene Chr7:33127867-33265377 (+)
LP/J MGP_LPJ_G0031981
protein coding gene Chr7:34594463-34730505 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031897
protein coding gene Chr7:36113442-36253108 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032559
protein coding gene Chr7:33695235-33830139 (+)
PWK/PhJ MGP_PWKPhJ_G0030841
protein coding gene Chr7:26530756-26664049 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030676
protein coding gene Chr7:23271104-23412746 (+)
WSB/EiJ MGP_WSBEiJ_G0031229
protein coding gene Chr7:34245574-34384917 (+)



Homology
more
  • Human Ortholog
    PEPD, peptidase D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PEPD, peptidase D
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PROLIDASE
  • Links
    NCBI Gene ID: 5184
    neXtProt AC: NX_P12955
    UniProt: P12955

  • Chr Location
    19q13.11; chr19:33386949-33521893 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Pepd mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 2 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants are smaller than normal siblings and, except on the flanks, an agouti coat appears nonagouti.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18624 NCBI Gene Model | MGI Sequence Detail 132302 C57BL/6J ±  kb
    transcript NM_008820 RefSeq | MGI Sequence Detail 1856 Not Specified  
    polypeptide Q11136 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 108
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13234, MGD-MRK-13239, MGI:1934634
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:5133 Lewis WH, et al., Electrophoretic heterogeneity of mouse erythrocyte peptidases. Biochem Genet. 1969 Oct;3(5):493-8
    • Latest
      J:246113 Bergemalm D, et al., Elevated fecal peptidase D at onset of colitis in Galphai2-/- mice, a mouse model of IBD. PLoS One. 2017;12(3):e0174275

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory