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Pepd
Gene Detail
 Symbol
Name
ID
Pepd
peptidase D
MGI:97542
Synonyms Pep4, Pep-4, peptidase D
Feature Type protein coding gene
Genetic Map
Chromosome 7
20.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr7:34912379-35044710 bp, + strand
From VEGA annotation of GRCm38

  132332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:239  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: aminopeptidase P
Gene Tree: Pepd

Human
homologs
Human Homolog PEPD, peptidase D
NCBI Gene ID 5184
neXtProt AC  NX_P12955
Human Synonyms  PROLIDASE
Human Chr (Location)  19q13.11; chr19:33386949-33521893 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PEPD
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pepd interacts with 70 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process collagen catabolic process, proteolysis
Component extracellular vesicular exosome
Function aminopeptidase activity, dipeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (196)    Tissues (99)    Images (31)
Theiler Stages: 17, 20, 23, 28
Assay TypeResults
RNA in situ 150
RT-PCR 46
cDNA source data(107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) Genomic(1) cDNA(107) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031826 (Evidence)
Ensembl Gene ModelENSMUSG00000063931 (Evidence)
Entrez Gene18624 (Evidence)
UniGene69751
DFCITC1575243
DoTSDT.490627
NIA Mouse Gene IndexU007964
EC3.4.13.9
Consensus CDS ProjectCCDS21143.1
International Mouse Knockout Project StatusPepd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031826 VEGA Gene Model | MGI Sequence Detail 132332 C57BL/6J ±  kb
transcript OTTMUST00000078912 VEGA | MGI Sequence Detail 1883 Not Applicable 
polypeptide OTTMUSP00000042019 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(1615 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1619)
Protein-related
information
ResourceIDDescription
InterPro IPR007865 Aminopeptidase P N-terminal domain
InterPro IPR001131 Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
InterPro IPR000994 Peptidase M24, structural domain
Protein Ontology PR:000012546 Xaa-Pro dipeptidase
References (Earliest) J:5133 Lewis WH, et al., Electrophoretic heterogeneity of mouse erythrocyte peptidases. Biochem Genet. 1969 Oct;3(5):493-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(58)
Other
accession IDs
MGD-MRK-13234, MGD-MRK-13239

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory