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Pecam1
Gene Detail
Symbol

Name
ID
Pecam1
platelet/endothelial cell adhesion molecule 1
MGI:97537
Synonyms
Cd31, PECAM-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
69.92 cM, cytoband F3-G1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:106654217-106750628 bp, - strand
From VEGA annotation of GRCm38

  96412 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PECAM1
Gene Tree: Pecam1

Human
homologs
PECAM1, platelet/endothelial cell adhesion molecule 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5175
neXtProt AC: NX_P16284

Human Synonyms: CD31, CD31/EndoCAM, endoCAM, GPIIA', PECA1, PECAM-1

Human Chr (Location): 17q23.3; chr17:64319415-64413801 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(451) : Gene trapped(449) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele show increased susceptibility to collagen-induced arthritis, impaired lung alveolarization, and enhanced susceptibility to endotoxic shock. Mice homozygous for a gene-trapped allele show altered vasodilation and nitric oxide homeostasis.
 
Interactions
Pecam1 interacts with 148 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell adhesion, diapedesis, ...
Component cell junction, cell periphery, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1296 records)
Data Summary: Results (1227)    Tissues (349)    Images (782)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 972
RNA in situ 145
Northern blot 6
Western blot 16
RT-PCR 88
cDNA source data(114)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) Genomic(2) cDNA(114) Primer pair(10) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003418 (Evidence)
Ensembl Gene Model ENSMUSG00000020717 (Evidence)
Entrez Gene 18613 (Evidence)
UniGene 343951
DFCI TC1575759, TC1590099, TC1626565, TC1642275
DoTS DT.101712762, DT.528306, DT.534741, DT.91288847, DT.94313019, DT.94380327, DT.97342919
NIA Mouse Gene Index U033547
Consensus CDS Project CCDS25558.1, CCDS25559.1
International Mouse Phenotyping Consortium Status Pecam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003418 VEGA Gene Model | MGI Sequence Detail 96412 C57BL/6J ±  kb
transcript OTTMUST00000007192 VEGA | MGI Sequence Detail 2977 Not Applicable 
polypeptide OTTMUSP00000003453 VEGA | MGI Sequence Detail 732 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(18) UniProt(4)
Polymorphisms
SNPs within 2kb(329 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001904 platelet endothelial cell adhesion molecule
References
(Earliest) J:2787 Bogen SA, et al., Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation. Am J Pathol. 1992 Oct;141(4):843-54
(Latest) J:222246 Klotz L, et al., Cardiac lymphatics are heterogeneous in origin and respond to injury. Nature. 2015 Jun 4;522(7554):62-7
All references(1445)
Other
accession IDs
MGD-MRK-13226, MGD-MRK-1848, MGI:2144682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory