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Pecam1 Gene Detail
Summary
  • Symbol
    Pecam1
  • Name
    platelet/endothelial cell adhesion molecule 1
  • Synonyms
    Cd31, PECAM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97537
    NCBI Gene: 18613
  • Gene Overview
    MyGene.info: PECAM1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106654213-106750623 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 69.92 cM, cytoband F3-G1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97537
protein coding gene Chr11:106654213-106750628 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019310
protein coding gene Chr11:109968923-110083952 (-)
A/J MGP_AJ_G0019278
protein coding gene Chr11:105283282-105382634 (-)
AKR/J MGP_AKRJ_G0019247
protein coding gene Chr11:108421425-108521287 (-)
BALB/cJ MGP_BALBcJ_G0019252
protein coding gene Chr11:105695524-105797694 (-)
C3H/HeJ MGP_C3HHeJ_G0019061
protein coding gene Chr11:108716365-108818011 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019702
protein coding gene Chr11:113357138-113481843 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017326
protein coding gene Chr11:102556261-102650772 (-)
CAST/EiJ MGP_CASTEiJ_G0018614
protein coding gene Chr11:109801253-109904053 (-)
CBA/J MGP_CBAJ_G0019030
protein coding gene Chr11:118064216-118183112 (-)
DBA/2J MGP_DBA2J_G0019142
protein coding gene Chr11:104752590-104852234 (-)
FVB/NJ MGP_FVBNJ_G0019133
protein coding gene Chr11:104265343-104365759 (-)
LP/J MGP_LPJ_G0019212
protein coding gene Chr11:110419066-110531095 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019163
protein coding gene Chr11:117308890-117421373 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019739
protein coding gene Chr11:108922325-109041385 (-)
PWK/PhJ MGP_PWKPhJ_G0018379
protein coding gene Chr11:105863621-105965773 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018170
protein coding gene Chr11:108705162-108816772 (-)
WSB/EiJ MGP_WSBEiJ_G0018665
protein coding gene Chr11:108908990-109013748 (-)



Homology
more
  • Human Ortholog
    PECAM1, platelet and endothelial cell adhesion molecule 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PECAM1, platelet and endothelial cell adhesion molecule 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD31, CD31/EndoCAM, endoCAM, GPIIA', PECA1, PECAM-1
  • Links
    NCBI Gene ID: 5175
    neXtProt AC: NX_P16284
    UniProt: P16284

  • Chr Location
    17q23.3; chr17:64319415-64413844 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 47925
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PECAM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show increased susceptibility to collagen-induced arthritis, impaired lung alveolarization, and enhanced susceptibility to endotoxic shock. Mice homozygous for a gene-trapped allele show altered vasodilation and nitric oxide homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18613 NCBI Gene Model | MGI Sequence Detail 96411 C57BL/6J ±  kb
    transcript NM_001305157 RefSeq | MGI Sequence Detail 3333 C57BL/6  
    polypeptide Q08481 UniProt | EBI | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      Genomic 2
      cDNA 116
      Primer pair 12
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13226, MGD-MRK-1848, MGI:2144682
    References
    more
    • Summaries
      All 1928
      Developmental Gene Expression 1754
      Gene Ontology 17
      Phenotypes 86
    • Earliest
      J:2787 Bogen SA, et al., Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation. Am J Pathol. 1992 Oct;141(4):843-54
    • Latest
      J:278877 Li Y, et al., Genetic Tracing Identifies Early Segregation of the Cardiomyocyte and Nonmyocyte Lineages. Circ Res. 2019 Jul 19;125(3):343-355

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory