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Pdyn
Gene Detail
Symbol

Name
ID
Pdyn
prodynorphin
MGI:97535
Synonyms
Dyn
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:129686565-129699844 bp, - strand
From VEGA annotation of GRCm38

  13280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: proenkephalin
Gene Tree: Pdyn

Human
homologs
Human Homolog PDYN, prodynorphin
NCBI Gene ID 5173
neXtProt AC  NX_P01213
Human Synonyms  ADCA, PENKB, SCA23
Human Chr (Location)  20p13; chr20:1978756-1994285 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PDYN
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.
 
Interactions
Pdyn interacts with 197 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (40)    Tissues (36)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 14
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(3) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015494 (Evidence)
Ensembl Gene ModelENSMUSG00000027400 (Evidence)
Entrez Gene18610 (Evidence)
UniGene6239
DFCITC1578059
DoTSDT.101248921, DT.55143306
NIA Mouse Gene IndexU023347
Consensus CDS ProjectCCDS38239.1
International Mouse Knockout Project StatusPdyn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015494 VEGA Gene Model | MGI Sequence Detail 13280 C57BL/6J ±  kb
transcript OTTMUST00000036784 VEGA | MGI Sequence Detail 2386 Not Applicable 
polypeptide OTTMUSP00000016506 VEGA | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006024 Opioid neuropeptide precursor
InterPro IPR000750 Proenkephalin B
Protein Ontology PR:000012526 proenkephalin-B
References
(Earliest) J:14668 Gulya K, et al., Prodynorphin and vasopressin mRNA levels are differentially affected by chronic ethanol ingestion in the mouse. Brain Res Mol Brain Res. 1993 Oct;20(1-2):1-8
(Latest) J:207472 Krashes MJ, et al., An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13;507(7491):238-42
All references(78)
Other
accession IDs
MGD-MRK-13223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory