Pdyn
Gene Detail

Symbol Name ID

Pdyn prodynorphin MGI:97535

Synonyms

Dyn

Feature Type

protein coding gene

Genetic Map

Chromosome 2

63.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:129686565-129699844 bp, - strand From VEGA annotation of GRCm38   13280 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: proenkephalin
Gene Tree: Pdyn

Human homologs

Human Homolog		PDYN, prodynorphin
NCBI Gene ID		5173
neXtProt AC		NX_P01213
Human Synonyms		ADCA, PENKB, SCA23
Human Chr (Location)		20p13; chr20:1959402-1974931 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PDYN

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene have altered responses to pain and to stress but otherwise display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	neuropeptide signaling pathway, synaptic transmission
Component	extracellular region, plasma membrane
Function	neuropeptide hormone activity, opioid peptide activity

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (40)    Tissues (36)    Images (9)
Theiler Stages: 17, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	26
RT-PCR	14

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(3) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015494 (Evidence)
Ensembl Gene Model	ENSMUSG00000027400 (Evidence)
Entrez Gene	18610 (Evidence)
UniGene	6239
DFCI	TC1578059
DoTS	DT.55143306
NIA Mouse Gene Index	U023347
Consensus CDS Project	CCDS38239.1
International Mouse Knockout Project Status	Pdyn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015494	VEGA Gene Model | MGI Sequence Detail	13280	C57BL/6J
transcript	OTTMUST00000036784	VEGA | MGI Sequence Detail	2386	Not Applicable
polypeptide	OTTMUSP00000016506	VEGA | MGI Sequence Detail	248	Not Applicable

All sequences(29) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs within 2kb(104 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR006024	Opioid neuropeptide precursor
InterPro	IPR000750	Proenkephalin B
Protein Ontology	PR:000012526	proenkephalin-B

References

(Earliest) J:14668 Gulya K, et al., Prodynorphin and vasopressin mRNA levels are differentially affected by chronic ethanol ingestion in the mouse. Brain Res Mol Brain Res. 1993 Oct;20(1-2):1-8
(Latest) J:191332 Henry AM, et al., High-resolution gene expression atlases for adult and developing mouse brain and spinal cord. Mamm Genome. 2012 Oct;23(9-10):539-49
All references(72)

Other accession IDs

MGD-MRK-13223