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Pdyn
Gene Detail
Symbol

Name
ID
Pdyn
prodynorphin
MGI:97535
Synonyms
Dyn
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:129686565-129699844 bp, - strand
From VEGA annotation of GRCm38

  13280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: PDYN
Protein SuperFamily: proenkephalin
Gene Tree: Pdyn

Human
homologs
PDYN, prodynorphin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5173
neXtProt AC: NX_P01213

Human Synonyms: ADCA, PENKB, SCA23

Human Chr (Location): 20p13; chr20:1978756-1994285 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PDYN

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.
 
Interactions
Pdyn interacts with 197 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process neuropeptide signaling pathway, synaptic transmission
Component cytoplasm, extracellular region, ...
Function neuropeptide hormone activity, opioid peptide activity
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (40)    Tissues (36)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 14
cDNA source data(5)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN pdyn    NEW 
Molecular
reagents
All nucleic(11) Genomic(3) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015494 (Evidence)
Ensembl Gene Model ENSMUSG00000027400 (Evidence)
Entrez Gene 18610 (Evidence)
UniGene 6239
DFCI TC1578059
DoTS DT.101248921, DT.55143306
NIA Mouse Gene Index U023347
Consensus CDS Project CCDS38239.1
International Mouse Phenotyping Consortium Status Pdyn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015494 VEGA Gene Model | MGI Sequence Detail 13280 C57BL/6J ±  kb
transcript OTTMUST00000036784 VEGA | MGI Sequence Detail 2386 Not Applicable 
polypeptide OTTMUSP00000016506 VEGA | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006024 Opioid neuropeptide precursor
InterPro IPR000750 Proenkephalin B
Protein Ontology PR:000012526 proenkephalin-B
References
(Earliest) J:14668 Gulya K, et al., Prodynorphin and vasopressin mRNA levels are differentially affected by chronic ethanol ingestion in the mouse. Brain Res Mol Brain Res. 1993 Oct;20(1-2):1-8
(Latest) J:219216 Duan B, et al., Identification of spinal circuits transmitting and gating mechanical pain. Cell. 2014 Dec 4;159(6):1417-32
All references(81)
Other
accession IDs
MGD-MRK-13223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory