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Pdyn
Gene Detail
 Symbol
Name
ID
Pdyn
prodynorphin
MGI:97535
Synonyms Dyn
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:129686565-129699844 bp, - strand
From VEGA annotation of GRCm38

  13280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: proenkephalin
Gene Tree: Pdyn

Human
homologs
Human Homolog PDYN, prodynorphin
NCBI Gene ID 5173
neXtProt AC  NX_P01213
Human Synonyms  ADCA, PENKB, SCA23
Human Chr (Location)  20p13; chr20:1978756-1994285 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PDYN
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for disruptions in this gene have altered responses to pain and to stress but otherwise display a normal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process neuropeptide signaling pathway, synaptic transmission
Component extracellular region, plasma membrane
Function neuropeptide hormone activity, opioid peptide activity
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (40)    Tissues (36)    Images (9)
Theiler Stages: 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 26
RT-PCR 14
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) Genomic(3) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015494 (Evidence)
Ensembl Gene ModelENSMUSG00000027400 (Evidence)
Entrez Gene18610 (Evidence)
UniGene6239
DFCITC1578059
DoTSDT.101248921, DT.55143306
NIA Mouse Gene IndexU023347
Consensus CDS ProjectCCDS38239.1
International Mouse Knockout Project StatusPdyn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015494 VEGA Gene Model | MGI Sequence Detail 13280 C57BL/6J ±  kb
transcript OTTMUST00000036784 VEGA | MGI Sequence Detail 2386 Not Applicable 
polypeptide OTTMUSP00000016506 VEGA | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006024 Opioid neuropeptide precursor
InterPro IPR000750 Proenkephalin B
Protein Ontology PR:000012526 proenkephalin-B
References (Earliest) J:14668 Gulya K, et al., Prodynorphin and vasopressin mRNA levels are differentially affected by chronic ethanol ingestion in the mouse. Brain Res Mol Brain Res. 1993 Oct;20(1-2):1-8
(Latest) J:201201 Anthwal N, et al., Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Dis Model Mech. 2013 Sep-Oct;6(5):1133-45
All references(76)
Other
accession IDs
MGD-MRK-13223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory