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Pdgfb
Gene Detail
 Symbol
Name
ID
Pdgfb
platelet derived growth factor, B polypeptide
MGI:97528
Synonyms PDGF-B, Sis
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.85 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(56)
Sequence Map
Chr15:79995900-80014808 bp, - strand
From Ensembl annotation of GRCm38

  18909 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: platelet-derived growth factor
Gene Tree: Pdgfb

Human
homologs
Human Homolog PDGFB, platelet-derived growth factor beta polypeptide
NCBI Gene ID 5155
neXtProt AC  NX_P01127
Human Synonyms  c-sis, IBGC5, PDGF2, PDGF-2, SIS, SSV
Human Chr (Location)  22q13.1; chr22:39223680-39244952 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human PDGFB
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Radiation induced(1) Targeted(6)
Genomic Mutations involving Pdgfb (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit absence of microvascular pericytes, capillary aneurisms, endothelial hyperplasia, edema, hemorrhages, erythroblastosis, macrocytic anemia, thrombocytopenia, kidney defects, and perinatal lethality.
 
Phenotype Images(1)
Interactions
Pdgfb interacts with 223 markers (Mir15b, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (101 annotations)
Process actin cytoskeleton organization, activation of protein kinase activity, ...
Component basolateral plasma membrane, cell surface, ...
Function chemoattractant activity, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (71)    Tissues (40)    Images (11)
Theiler Stages: 9, 11, 13, 14, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 28
RNA in situ 5
Northern blot 7
Western blot 11
RT-PCR 4
RNase protection 16
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(12) cDNA(25) Primer pair(4) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000000489 (Evidence)
Entrez Gene18591 (Evidence)
UniGene144089
DFCITC1583040, TC1589294, TC1704034
DoTSDT.101707310, DT.528267
NIA Mouse Gene IndexU036419
PDB2DZ4, 2DZ5
Consensus CDS ProjectCCDS27656.1
International Mouse Knockout Project StatusPdgfb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000489 Ensembl Gene Model | MGI Sequence Detail 18909 C57BL/6J ±  kb
transcript ENSMUST00000000500 Ensembl | MGI Sequence Detail 2918 Not Applicable 
polypeptide ENSMUSP00000000500 Ensembl | MGI Sequence Detail 241 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(3)
Polymorphisms All PCR and RFLP(10) : PCR(3) RFLP(7) SNPs within 2kb(216 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR006782 Platelet-derived growth factor, N-terminal
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000012491 platelet-derived growth factor subunit B
References (Earliest) J:6890 Dalla-Favera R, et al., Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science. 1982 Nov 12;218(4573):686-8
(Latest) J:205303 Keller A, et al., Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat Genet. 2013 Sep;45(9):1077-82
All references(211)
Other
accession IDs
MGD-MRK-13212, MGD-MRK-14423

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory