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Pdgfb Gene Detail
Summary
  • Symbol
    Pdgfb
  • Name
    platelet derived growth factor, B polypeptide
  • Synonyms
    PDGF-B, Sis
  • Feature Type
    protein coding gene
  • IDs
    MGI:97528
    NCBI Gene: 18591
  • Gene Overview
    MyGene.info: PDGFB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:79995900-80014808 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18909 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E
  • Mapping Data
    56 experiments
Homology
more
  • Human Ortholog
    PDGFB, platelet derived growth factor subunit B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDGFB, platelet derived growth factor subunit B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c-sis, IBGC5, PDGF2, PDGF-2, SIS, SSV
  • Links
    NCBI Gene ID: 5155
    neXtProt AC: NX_P01127
    UniProt: P01127

  • Chr Location
    22q13.1; chr22:39223359-39245055 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human PDGFB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 3 alleles in 6 genetic backgrounds
    31 phenotypes from multigenic genotypes
    1 images
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit absence of microvascular pericytes, capillary aneurisms, endothelial hyperplasia, edema, hemorrhages, erythroblastosis, macrocytic anemia, thrombocytopenia, kidney defects, and perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000489 Ensembl Gene Model | MGI Sequence Detail 18909 C57BL/6J ±  kb
    transcript ENSMUST00000000500 Ensembl | MGI Sequence Detail 2918 Not Applicable  
    polypeptide ENSMUSP00000000500 Ensembl | MGI Sequence Detail 241 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      215 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR000072 PDGF/VEGF domain
      IPR023581 Platelet-derived growth factor, conserved site
      IPR006782 Platelet-derived growth factor, N-terminal
      IPR015583 Platelet-derived growth factor subunit B
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 12
      cDNA 26
      Primer pair 5
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13212, MGD-MRK-14423
    References
    more
    • Summaries
      All 261
      Developmental Gene Expression 72
      Diseases 2
      Gene Ontology 20
      Phenotypes 60
    • Earliest
      J:6890 Dalla-Favera R, et al., Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science. 1982 Nov 12;218(4573):686-8
    • Latest
      J:251917 Wang Y, et al., Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nat Commun. 2017 Sep 18;8(1):578

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory