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Pdgfb Gene Detail
Summary
  • Symbol
    Pdgfb
  • Name
    platelet derived growth factor, B polypeptide
  • Synonyms
    PDGF-B, Sis
  • Feature Type
    protein coding gene
  • IDs
    MGI:97528
    NCBI Gene: 18591
  • Gene Overview
    MyGene.info: PDGFB
Location & Maps
more
  • Sequence Map
    Chr15:79995900-80014808 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18909 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PDGFB, platelet derived growth factor subunit B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDGFB, platelet derived growth factor subunit B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    c-sis, IBGC5, PDGF2, PDGF-2, SIS, SSV
  • Links
    NCBI Gene ID: 5155
    neXtProt AC: NX_P01127

  • Chr Location
    22q13.1; chr22:39223680-39244952 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with human PDGFB associations

Human Disease Mouse Models
       Basal Ganglia Calcification, Idiopathic, 1; IBGC1   OMIM: 213600
Basal Ganglia Calcification, Idiopathic, 5; IBGC5   OMIM: 615483
Dermatofibrosarcoma Protuberans; DFSP   OMIM: 607907
Meningioma, Familial, Susceptibility to   OMIM: 607174
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 3 alleles in 6 genetic backgrounds
    30 phenotypes from multigenic genotypes
    1 images
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    8
  • Transgenic
    3
  • Genomic Mutations
    3 involving Pdgfb
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit absence of microvascular pericytes, capillary aneurisms, endothelial hyperplasia, edema, hemorrhages, erythroblastosis, macrocytic anemia, thrombocytopenia, kidney defects, and perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000489 Ensembl Gene Model | MGI Sequence Detail 18909 C57BL/6J ±  kb
transcript ENSMUST00000000500 Ensembl | MGI Sequence Detail 2918 Not Applicable  
polypeptide ENSMUSP00000000500 Ensembl | MGI Sequence Detail 241 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    215 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 12
    cDNA 25
    Primer pair 4
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13212, MGD-MRK-14423
References
more
  • Summaries
    All 206
    Developmental Gene Expression 66
    Diseases 1
    Gene Ontology 20
    Phenotypes 56
  • Earliest
    J:6890 Dalla-Favera R, et al., Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science. 1982 Nov 12;218(4573):686-8
  • Latest
    J:225966 Hong J, et al., Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells. J Natl Cancer Inst. 2015 Oct;107(10)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory