Furin
Gene Detail

Symbol Name ID

Furin furin (paired basic amino acid cleaving enzyme) MGI:97513

Synonyms

9130404I01Rik, Fur, PACE, Pcsk3, SPC1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.65 cM, cytoband D1-E2
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr7:80388585-80405436 bp, - strand From VEGA annotation of GRCm38   16852 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1930  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: proprotein convertase, subtilisin/kexin type
Gene Tree: Furin

Human homologs

Human Homolog		FURIN, furin (paired basic amino acid cleaving enzyme)
NCBI Gene ID		5045
neXtProt AC		NX_P09958
Human Synonyms		FUR, PACE, PCSK3, SPC1
Human Chr (Location)		15q26.1; chr15:91411885-91426687 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Homozygous null embryos die at E10.5-E11.5. Embryos homozygous for one knock-out allele show multiple tissue abnormalities including abnormal yolk sac vasculature and chorioallantoic fusion, failure of axial rotation, a kinked neural tube, exencephaly and severe ventral closure and cardiac defects.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	cell proliferation, negative regulation of low-density lipoprotein particle receptor catabolic process, ...
Component	cell surface, early endosome, ...
Function	endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (69)    Tissues (30)    Images (31)
Theiler Stages: 1, 2, 3, 4, 5, 11, 12, 15, 23, 28

Assay Type	Results
RNA in situ	45
Northern blot	6
RT-PCR	18

cDNA source data(95)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(101) Genomic(1) cDNA(96) Primer pair(2) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028566 (Evidence)
Ensembl Gene Model	ENSMUSG00000030530 (Evidence)
Entrez Gene	18550 (Evidence)
UniGene	5241
DFCI	TC1575784, TC1718451
DoTS	DT.101377374, DT.55129553, DT.87072516
NIA Mouse Gene Index	U008284, U028764
EC	3.4.21.75
PDB	1P8J
Consensus CDS Project	CCDS21397.1
International Mouse Knockout Project Status	Furin

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028566	VEGA Gene Model | MGI Sequence Detail	16852	C57BL/6J
transcript	OTTMUST00000070797	VEGA | MGI Sequence Detail	4286	Not Applicable
polypeptide	OTTMUSP00000036135	VEGA | MGI Sequence Detail	793	Not Applicable

All sequences(46) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(121 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006212	Furin-like repeat
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR000209	Peptidase S8/S53 domain
InterPro	IPR023827	Peptidase S8, subtilisin, Asp-active site
InterPro	IPR022398	Peptidase S8, subtilisin, His-active site
InterPro	IPR015500	Peptidase S8, subtilisin-related
InterPro	IPR023828	Peptidase S8, subtilisin, Ser-active site
InterPro	IPR002884	Proprotein convertase, P
InterPro	IPR009020	Proteinase inhibitor, propeptide
Protein Ontology	PR:000003137	furin

References

(Earliest) J:23406 Hatsuzawa K, et al., Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. J Biol Chem. 1990 Dec 25;265(36):22075-8
(Latest) J:196532 Kim W, et al., Loss of endothelial furin leads to cardiac malformation and early postnatal death. Mol Cell Biol. 2012 Sep;32(17):3382-91
All references(88)

Other accession IDs

MGD-MRK-13193, MGD-MRK-9893, MGI:1925399