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Furin Gene Detail
Summary
  • Symbol
    Furin
  • Name
    furin (paired basic amino acid cleaving enzyme)
  • Synonyms
    9130404I01Rik, Fur, PACE, Pcsk3, SPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97513
    NCBI Gene: 18550
  • Gene Overview
    MyGene.info: FURIN
Location & Maps
more
  • Sequence Map
    Chr7:80388585-80405436 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16852 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.65 cM, cytoband D1-E2
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    FURIN, furin, paired basic amino acid cleaving enzyme
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FURIN, furin, paired basic amino acid cleaving enzyme
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FUR, PACE, PCSK3, SPC1
  • Links
    NCBI Gene ID: 5045
    neXtProt AC: NX_P09958

  • Chr Location
    15q26.1; chr15:90868592-90883458 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Furin
  • Incidental Mutations
Homozygous null embryos die at E10.5-E11.5. Embryos homozygous for one knock-out allele show multiple tissue abnormalities including abnormal yolk sac vasculature and chorioallantoic fusion, failure of axial rotation, a kinked neural tube, exencephaly and severe ventral closure and cardiac defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028566 VEGA Gene Model | MGI Sequence Detail 16852 C57BL/6J ±  kb
transcript OTTMUST00000070797 VEGA | MGI Sequence Detail 4286 Not Applicable  
polypeptide OTTMUSP00000036135 VEGA | MGI Sequence Detail 793 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    154 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 104
    Genomic 1
    cDNA 99
    Primer pair 2
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13193, MGD-MRK-9893, MGI:1925399
References
more
  • Summaries
    All 94
    Developmental Gene Expression 19
    Gene Ontology 15
    Phenotypes 34
  • Earliest
    J:23406 Hatsuzawa K, et al., Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. J Biol Chem. 1990 Dec 25;265(36):22075-8
  • Latest
    J:227651 Bessonnard S, et al., PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation. J Cell Biol. 2015 Sep 28;210(7):1185-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory