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Furin
Gene Detail
Symbol

Name
ID
Furin
furin (paired basic amino acid cleaving enzyme)
MGI:97513
Synonyms
9130404I01Rik, Fur, PACE, Pcsk3, SPC1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.65 cM, cytoband D1-E2
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr7:80388585-80405436 bp, - strand
From VEGA annotation of GRCm38

  16852 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1930  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: proprotein convertase, subtilisin/kexin type
Gene Tree: Furin

Human
homologs
Human Homolog FURIN, furin (paired basic amino acid cleaving enzyme)
NCBI Gene ID 5045
neXtProt AC  NX_P09958
Human Synonyms  FUR, PACE, PCSK3, SPC1
Human Chr (Location)  15q26.1; chr15:90868655-90883457 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die at E10.5-E11.5. Embryos homozygous for one knock-out allele show multiple tissue abnormalities including abnormal yolk sac vasculature and chorioallantoic fusion, failure of axial rotation, a kinked neural tube, exencephaly and severe ventral closure and cardiac defects.
 
Interactions
Furin interacts with 243 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cell proliferation, negative regulation of endopeptidase activity, ...
Component cell surface, early endosome, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (65)    Tissues (26)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
Northern blot 6
RT-PCR 14
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) Genomic(1) cDNA(99) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028566 (Evidence)
Ensembl Gene ModelENSMUSG00000030530 (Evidence)
Entrez Gene18550 (Evidence)
UniGene5241
DFCITC1575784, TC1718451
DoTSDT.101377374, DT.55129553, DT.87072516
NIA Mouse Gene IndexU008284, U028764
EC3.4.21.75
PDB1P8J
Consensus CDS ProjectCCDS21397.1
International Mouse Knockout Project StatusFurin
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028566 VEGA Gene Model | MGI Sequence Detail 16852 C57BL/6J ±  kb
transcript OTTMUST00000070798 VEGA | MGI Sequence Detail 4332 Not Applicable 
polypeptide OTTMUSP00000036136 VEGA | MGI Sequence Detail 793 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(163 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006212 Furin-like repeat
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000209 Peptidase S8/S53 domain
InterPro IPR023827 Peptidase S8, subtilisin, Asp-active site
InterPro IPR022398 Peptidase S8, subtilisin, His-active site
InterPro IPR015500 Peptidase S8, subtilisin-related
InterPro IPR023828 Peptidase S8, subtilisin, Ser-active site
InterPro IPR002884 Proprotein convertase, P
InterPro IPR009020 Proteinase inhibitor, propeptide
Protein Ontology PR:000003137 furin
References
(Earliest) J:23406 Hatsuzawa K, et al., Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. J Biol Chem. 1990 Dec 25;265(36):22075-8
(Latest) J:204761 Edwards JP, et al., Regulation of the expression of GARP/latent TGF-beta1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol. 2013 Jun 1;190(11):5506-15
All references(93)
Other
accession IDs
MGD-MRK-13193, MGD-MRK-9893, MGI:1925399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory