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Furin Gene Detail
Summary
  • Symbol
    Furin
  • Name
    furin (paired basic amino acid cleaving enzyme)
  • Synonyms
    9130404I01Rik, Fur, PACE, Pcsk3, SPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97513
    NCBI Gene: 18550
  • Gene Overview
    MyGene.info: FURIN
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80389194-80405441 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.65 cM, cytoband D1-E2
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97513
protein coding gene Chr7:80388585-80405441 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032415
protein coding gene Chr7:82360191-82378087 (-)
A/J MGP_AJ_G0032394
protein coding gene Chr7:80432182-80448817 (-)
AKR/J MGP_AKRJ_G0032330
protein coding gene Chr7:82177031-82193666 (-)
BALB/cJ MGP_BALBcJ_G0032406
protein coding gene Chr7:80106800-80124303 (-)
C3H/HeJ MGP_C3HHeJ_G0032119
protein coding gene Chr7:82824963-82841830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032898
protein coding gene Chr7:85596525-85615100 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029906
protein coding gene Chr7:82952599-82969373 (-)
CAST/EiJ MGP_CASTEiJ_G0031447
protein coding gene Chr7:73713405-73730076 (-)
CBA/J MGP_CBAJ_G0032085
protein coding gene Chr7:88435580-88455086 (-)
DBA/2J MGP_DBA2J_G0032240
protein coding gene Chr7:78989968-79007048 (-)
FVB/NJ MGP_FVBNJ_G0032195
protein coding gene Chr7:78904069-78921335 (-)
LP/J MGP_LPJ_G0032321
protein coding gene Chr7:83599935-83617698 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032232
protein coding gene Chr7:88589606-88608787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032916
protein coding gene Chr7:81607111-81627046 (-)
PWK/PhJ MGP_PWKPhJ_G0031167
protein coding gene Chr7:72178349-72195664 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031008
protein coding gene Chr7:68617998-68635671 (-)
WSB/EiJ MGP_WSBEiJ_G0031565
protein coding gene Chr7:81969903-81987772 (-)



Homology
more
  • Human Ortholog
    FURIN, furin, paired basic amino acid cleaving enzyme
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FURIN, furin, paired basic amino acid cleaving enzyme
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FUR, PACE, PCSK3, SPC1
  • Links
    NCBI Gene ID: 5045
    neXtProt AC: NX_P09958
    UniProt: P09958

  • Chr Location
    15q26.1; chr15:90868592-90883458 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos die at E10.5-E11.5. Embryos homozygous for one knock-out allele show multiple tissue abnormalities including abnormal yolk sac vasculature and chorioallantoic fusion, failure of axial rotation, a kinked neural tube, exencephaly and severe ventral closure and cardiac defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18550 NCBI Gene Model | MGI Sequence Detail 16248 C57BL/6J ±  kb
    transcript NM_011046 RefSeq | MGI Sequence Detail 4336 C57BL/6  
    polypeptide P23188 UniProt | EBI | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 1
      cDNA 100
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13193, MGD-MRK-9893, MGI:1925399
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 20
      Gene Ontology 16
      Phenotypes 38
    • Earliest
      J:23406 Hatsuzawa K, et al., Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. J Biol Chem. 1990 Dec 25;265(36):22075-8
    • Latest
      J:252592 Al Rifai O, et al., Proprotein convertase furin regulates osteocalcin and bone endocrine function. J Clin Invest. 2017 Nov 1;127(11):4104-4117

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory