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Pcna
Gene Detail
Symbol

Name
ID
Pcna
proliferating cell nuclear antigen
MGI:97503
Feature Type
protein coding gene
Genetic Map
Chromosome 2
64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr2:132249162-132253314 bp, - strand
From VEGA annotation of GRCm38

  4153 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PCNA
Protein SuperFamily: DNA polymerase sliding clamp
Gene Tree: Pcna

Human
homologs
PCNA, proliferating cell nuclear antigen
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5111
neXtProt AC: NX_P12004

Human Synonyms: ATLD2

Human Chr (Location): 20pter-p12; chr20:5114953-5126622 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PCNA

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation due to defects in DNA replication. Mice homozygous for a knock-in allele show partial embryonic lethality during organogenesis, absent germ cells, infertility, and altered somatic hypermutation frequency.
 
Interactions
Pcna interacts with 115 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (470 records)
Data Summary: Results (417)    Tissues (162)    Images (210)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 215
RNA in situ 117
Western blot 49
RT-PCR 36
cDNA source data(297)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PCNA ; Xenbase pcna ; ZFIN pcna    NEW 
Molecular
reagents
All nucleic(306) Genomic(5) cDNA(298) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015547 (Evidence)
Ensembl Gene Model ENSMUSG00000027342 (Evidence)
Entrez Gene 18538 (Evidence)
UniGene 7141
DFCI TC1573145
DoTS DT.101390808, DT.495829, DT.91592091
NIA Mouse Gene Index U023392, U059727
Consensus CDS Project CCDS16771.1
International Mouse Phenotyping Consortium Status Pcna
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015547 VEGA Gene Model | MGI Sequence Detail 4153 C57BL/6J ±  kb
transcript OTTMUST00000036927 VEGA | MGI Sequence Detail 1518 Not Applicable 
polypeptide OTTMUSP00000016567 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(4)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000730 Proliferating cell nuclear antigen, PCNA
InterPro IPR022659 Proliferating cell nuclear antigen, PCNA, conserved site
InterPro IPR022649 Proliferating cell nuclear antigen, PCNA, C-terminal
InterPro IPR022648 Proliferating cell nuclear antigen, PCNA, N-terminal
Protein Ontology PR:000012421 proliferating cell nuclear antigen
References
(Earliest) J:11220 Yamaguchi M, et al., Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen. Nucleic Acids Res. 1991 May 11;19(9):2403-10
(Latest) J:221142 Beketaev I, et al., Critical role of YY1 in cardiac morphogenesis. Dev Dyn. 2015 May;244(5):669-80
All references(551)
Other
accession IDs
MGD-MRK-13178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory