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Pcna
Gene Detail
 Symbol
Name
ID
Pcna
proliferating cell nuclear antigen
MGI:97503
Feature Type protein coding gene
Genetic Map
Chromosome 2
64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr2:132249162-132253314 bp, - strand
From VEGA annotation of GRCm38

  4153 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA polymerase sliding clamp
Gene Tree: Pcna

Human
homologs
Human Homolog PCNA, proliferating cell nuclear antigen
NCBI Gene ID 5111
neXtProt AC  NX_P12004
Human Synonyms  ATLD2
Human Chr (Location)  20pter-p12; chr20:5114953-5126622 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PCNA
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation due to defects in DNA replication. Mice homozygous for a knock-in allele show partial embryonic lethality during organogenesis, absent germ cells, infertility, and altered somatic hypermutation frequency.
 
Interactions
Pcna interacts with 115 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process base-excision repair, gap-filling, cellular response to DNA damage stimulus, ...
Component centrosome, cyclin-dependent protein kinase holoenzyme complex, ...
Function dinucleotide insertion or deletion binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (437 records)
Data Summary: Results (397)    Tissues (148)    Images (192)
Theiler Stages: 2, 3, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 198
RNA in situ 117
Western blot 46
RT-PCR 36
cDNA source data(296)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(305) Genomic(5) cDNA(297) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015547 (Evidence)
Ensembl Gene ModelENSMUSG00000027342 (Evidence)
Entrez Gene18538 (Evidence)
UniGene7141
DFCITC1573145
DoTSDT.101390808, DT.495829, DT.91592091
NIA Mouse Gene IndexU023392, U059727
Consensus CDS ProjectCCDS16771.1
International Mouse Knockout Project StatusPcna
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015547 VEGA Gene Model | MGI Sequence Detail 4153 C57BL/6J ±  kb
transcript OTTMUST00000036927 VEGA | MGI Sequence Detail 1518 Not Applicable 
polypeptide OTTMUSP00000016567 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(4)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000730 Proliferating cell nuclear antigen, PCNA
InterPro IPR022659 Proliferating cell nuclear antigen, PCNA, conserved site
InterPro IPR022649 Proliferating cell nuclear antigen, PCNA, C-terminal
InterPro IPR022648 Proliferating cell nuclear antigen, PCNA, N-terminal
Protein Ontology PR:000012421 proliferating cell nuclear antigen
References (Earliest) J:11220 Yamaguchi M, et al., Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen. Nucleic Acids Res. 1991 May 11;19(9):2403-10
(Latest) J:208830 Lin SS, et al., Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1990-8
All references(519)
Other
accession IDs
MGD-MRK-13178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory