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Pcna Gene Detail
Summary
  • Symbol
    Pcna
  • Name
    proliferating cell nuclear antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:97503
    NCBI Gene: 18538
Location & Maps
more
  • Sequence Map
    Chr2:132249162-132253314 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4153 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 64.15 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    PCNA, proliferating cell nuclear antigen
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCNA, proliferating cell nuclear antigen
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATLD2
  • Links
    NCBI Gene ID: 5111
    neXtProt AC: NX_P12004

  • Chr Location
    20pter-p12; chr20:5114953-5126622 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PCNA associations

Human Disease Mouse Models
       Ataxia-Telangiectasia-Like Disorder 2; ATLD2   OMIM: 615919
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Pcna
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation due to defects in DNA replication. Mice homozygous for a knock-in allele show partial embryonic lethality during organogenesis, absent germ cells, infertility, and altered somatic hypermutation frequency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015547 VEGA Gene Model | MGI Sequence Detail 4153 C57BL/6J ±  kb
transcript OTTMUST00000036927 VEGA | MGI Sequence Detail 1518 Not Applicable  
polypeptide OTTMUSP00000016567 VEGA | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR000730 Proliferating cell nuclear antigen, PCNA
    IPR022659 Proliferating cell nuclear antigen, PCNA, conserved site
    IPR022649 Proliferating cell nuclear antigen, PCNA, C-terminal
    IPR022648 Proliferating cell nuclear antigen, PCNA, N-terminal
Molecular
Reagents
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  • All nucleic 307
    Genomic 5
    cDNA 299
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13178
References
more
  • Summaries
    All 570
    Developmental Gene Expression 492
    Gene Ontology 29
    Phenotypes 11
  • Earliest
    J:11220 Yamaguchi M, et al., Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen. Nucleic Acids Res. 1991 May 11;19(9):2403-10
  • Latest
    J:231951 Nakamura A, et al., Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors. J Neurosci. 2016 May 18;36(20):5448-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory