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Pbx3 Gene Detail
Summary
  • Symbol
    Pbx3
  • Name
    pre B cell leukemia homeobox 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97496
    NCBI Gene: 18516
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:34061469-34263154 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.84 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2858 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97496
 protein coding gene Chr2:34061469-34264168 (-)
129S1/SvImJ ENSMUSG00200045612
 protein coding gene Chr2:31040719-31242428 (-)
A/J ENSMUSG00195035724
 protein coding gene Chr2:31142965-31344593 (-)
AKR/J ENSMUSG00220042170
 protein coding gene Chr2:31257924-31459535 (-)
BALB/cJ ENSMUSG00180046608
 protein coding gene Chr2:31157048-31358778 (-)
C3H/HeJ ENSMUSG00175039871
 protein coding gene Chr2:31123413-31325116 (-)
C57BL/6NJ ENSMUSG00215046506
 protein coding gene Chr2:31190488-31392221 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023464
 protein coding gene Chr2:30077262-30273512 (-)
CAST/EiJ ENSTCUG00005017379
 protein coding gene Chr2:30871105-31069676 (-)
CBA/J ENSMUSG00210047659
 protein coding gene Chr2:31195845-31397521 (-)
DBA/2J ENSMUSG00185046101
 protein coding gene Chr2:31056031-31257636 (-)
FVB/NJ ENSMUSG00205033395
 protein coding gene Chr2:30903710-31105331 (-)
JF1/MsJ ENSUMUG00000006966
 protein coding gene Chr2:30948884-31147980 (-)
LP/J ENSMUSG00230039779
 protein coding gene Chr2:32976135-33177829 (-)
NOD/ShiLtJ ENSMUSG00190036872
 protein coding gene Chr2:31157366-31358981 (-)
NZO/HlLtJ ENSMUSG00225048572
 protein coding gene Chr2:40733040-40934803 (-)
PWK/PhJ ENSLUMG00010042363
 protein coding gene Chr2:31038395-31237571 (-)
SPRET/EiJ ENSMSPG00010033745
 protein coding gene Chr2:31749413-31945971 (-)
WSB/EiJ ENSIUOG00005038898
 protein coding gene Chr2:31014485-31216400 (-)



Homology
more
  • Human Ortholog
    PBX3, PBX homeobox 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PBX3, PBX homeobox 3
  • Links
    NCBI Gene ID: 5090
    UniProt: P40426

  • Chr Location
    9q33.3; chr9:125746737-125967377 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 5 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with hypoventilation and respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1008
  • Tissues
    245
  • cDNA Data
    53
  • Literature Summary
    67
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038718 Ensembl Gene Model | MGI Sequence Detail 201686 C57BL/6J ±  kb
    transcript ENSMUST00000040638 Ensembl | MGI Sequence Detail 2587 Not Applicable  
    polypeptide ENSMUSP00000045281 Ensembl | MGI Sequence Detail 434 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 55
      Primer pair 6
      Other 4
      Antibodies 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13165
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 67
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
    • Latest
      J:389923 Muchamedin A, et al., Pbx1 and Pbx3 cooperatively regulate intermediate progenitor genesis and corticogenesis in the mouse neocortex. Front Cell Dev Biol. 2026;14:1809251
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory