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Pbx3
Gene Detail
 Symbol
Name
ID
Pbx3
pre B cell leukemia homeobox 3
MGI:97496
Feature Type protein coding gene
Genetic Map
Chromosome 2
22.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:34171457-34373142 bp, - strand
From VEGA annotation of GRCm38

  201686 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pbx3

Human
homologs
Human Homolog PBX3, pre-B-cell leukemia homeobox 3
NCBI Gene ID 5090
neXtProt AC  NX_P40426
Human Chr (Location)  9q33.3; chr9:125747338-125967377 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality with hypoventilation and respiratory failure.
 
Interactions
Pbx3 interacts with 365 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process adult locomotory behavior, dorsal spinal cord development, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (275)    Tissues (175)    Images (83)
Theiler Stages: 2, 3, 4, 5, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 27, 28
Assay TypeResults
RNA in situ 263
Western blot 4
RT-PCR 8
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(49) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000011928 (Evidence)
Ensembl Gene ModelENSMUSG00000038718 (Evidence)
Entrez Gene18516 (Evidence)
UniGene239941
DFCITC1579634, TC1590924, TC1605147, TC1626834, TC1633236
DoTSDT.531398, DT.55108378, DT.94205233, DT.94251207
Consensus CDS ProjectCCDS15947.1, CCDS71033.1
International Mouse Knockout Project StatusPbx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011928 VEGA Gene Model | MGI Sequence Detail 201686 C57BL/6J ±  kb
transcript OTTMUST00000028160 VEGA | MGI Sequence Detail 2587 Not Applicable 
polypeptide OTTMUSP00000012746 VEGA | MGI Sequence Detail 434 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(8) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(745 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR005542 PBX
Protein Ontology PR:000012328 pre-B-cell leukemia transcription factor 3
References (Earliest) J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
(Latest) J:199302 Veenvliet JV, et al., Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development. 2013 Aug;140(16):3373-84
All references(80)
Other
accession IDs
MGD-MRK-13165

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory