Pbx3
Gene Detail

Symbol Name ID

Pbx3 pre B cell leukemia homeobox 3 MGI:97496

Feature Type

protein coding gene

Genetic Map

Chromosome 2

22.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr2:34171457-34373140 bp, - strand From VEGA annotation of GRCm38   201684 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pbx3

Human homologs

Human Homolog		PBX3, pre-B-cell leukemia homeobox 3
NCBI Gene ID		5090
neXtProt AC		NX_P40426
Human Chr (Location)		9q33.3; chr9:128509617-128729656 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(5)
 

Homozygous null mice display neonatal lethality with hypoventilation and respiratory failure.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	adult locomotory behavior, dorsal spinal cord development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (37 records)
Data Summary: Results (282)    Tissues (177)    Images (83)
Theiler Stages: 2, 3, 4, 5, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	263
Western blot	4
RT-PCR	15

cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(49) Primer pair(1) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000011928 (Evidence)
Ensembl Gene Model	ENSMUSG00000038718 (Evidence)
Entrez Gene	18516 (Evidence)
UniGene	239941
DFCI	TC1579634, TC1590924, TC1605147, TC1626834
DoTS	DT.531398, DT.55108378, DT.94205233, DT.94251207
Consensus CDS Project	CCDS15947.1
International Mouse Knockout Project Status	Pbx3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011928	VEGA Gene Model | MGI Sequence Detail	201684	C57BL/6J
transcript	OTTMUST00000028160	VEGA | MGI Sequence Detail	2607	Not Applicable
polypeptide	OTTMUSP00000012746	VEGA | MGI Sequence Detail	434	Not Applicable

All sequences(72) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(2) : SNPs(417 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR005542	PBX
Protein Ontology	PR:000012328	pre-B-cell leukemia transcription factor 3

References

(Earliest) J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
(Latest) J:185964 Sgado P, et al., The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons. Neural Dev. 2012;7:24
All references(77)

Other accession IDs

MGD-MRK-13165