Pax4
Gene Detail

Symbol Name ID

Pax4 paired box gene 4 MGI:97488

Synonyms

Pax-4

Feature Type

protein coding gene

Genetic Map

Chromosome 6

11.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:28442334-28449353 bp, - strand From VEGA annotation of GRCm38   7020 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4515  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: paired box protein PAX
Gene Tree: Pax4

Human homologs

Human Homolog		PAX4, paired box 4
NCBI Gene ID		5078
neXtProt AC		NX_O43316
Human Synonyms		KPD, MODY9
Human Chr (Location)		7q32; chr7:127250346-127255780 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human PAX4

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for this targeted mutation lack mature insulin- and somatostatin-producing cells (beta and delta, respectively) in the pancreas, but contain glucagon-producing alpha cells in considerably higher numbers relative to wild-type mice.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (84)    Tissues (50)    Images (7)
Theiler Stages: 17, 19, 20, 21, 23, 26, 28

Assay Type	Results
RNA in situ	75
RT-PCR	9

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(6) cDNA(11) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035782 (Evidence)
Ensembl Gene Model	ENSMUSG00000029706 (Evidence)
Entrez Gene	18506 (Evidence)
UniGene	8026
DFCI	TC1589505
DoTS	DT.87050059
NIA Mouse Gene Index	U027102
Consensus CDS Project	CCDS39447.1, CCDS51731.1, CCDS51732.1
International Mouse Knockout Project Status	Pax4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035782	VEGA Gene Model | MGI Sequence Detail	7020	C57BL/6J
transcript	OTTMUST00000091572	VEGA | MGI Sequence Detail	1370	Not Applicable
polypeptide	OTTMUSP00000050451	VEGA | MGI Sequence Detail	349	Not Applicable

All sequences(49) RefSeq(6) UniProt(4)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(90 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR001523	Paired domain
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000012317	paired box protein Pax-4

References

(Earliest) J:11577 Walther C, et al., Pax: a murine multigene family of paired box-containing genes. Genomics. 1991 Oct;11(2):424-34
(Latest) J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
All references(78)

Other accession IDs

MGD-MRK-13147, MGD-MRK-13156