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Pax4
Gene Detail
Symbol

Name
ID
Pax4
paired box 4
MGI:97488
Synonyms
Pax-4
Feature Type
protein coding gene
Genetic Map
Chromosome 6
11.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:28442334-28449353 bp, - strand
From VEGA annotation of GRCm38

  7020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4515  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: paired box protein PAX
Gene Tree: Pax4

Human
homologs
Human Homolog PAX4, paired box 4
NCBI Gene ID 5078
neXtProt AC  NX_O43316
Human Synonyms  KPD, MODY9
Human Chr (Location)  7q32; chr7:127610292-127615928 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human PAX4
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for this targeted mutation lack mature insulin- and somatostatin-producing cells (beta and delta, respectively) in the pancreas, but contain glucagon-producing alpha cells in considerably higher numbers relative to wild-type mice.
 
Interactions
Pax4 interacts with 15 markers (Mir130b, Mir138-1, Mir138-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus, transcription factor complex
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (84)    Tissues (50)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
RT-PCR 9
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(6) cDNA(11) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035782 (Evidence)
Ensembl Gene ModelENSMUSG00000029706 (Evidence)
Entrez Gene18506 (Evidence)
UniGene8026
DFCITC1589505
DoTSDT.87050059
NIA Mouse Gene IndexU027102
Consensus CDS ProjectCCDS39447.1, CCDS51731.1, CCDS51732.1
International Mouse Knockout Project StatusPax4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035782 VEGA Gene Model | MGI Sequence Detail 7020 C57BL/6J ±  kb
transcript OTTMUST00000091572 VEGA | MGI Sequence Detail 1370 Not Applicable 
polypeptide OTTMUSP00000050451 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(7)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001523 Paired domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000012317 paired box protein Pax-4
References
(Earliest) J:11577 Walther C, et al., Pax: a murine multigene family of paired box-containing genes. Genomics. 1991 Oct;11(2):424-34
(Latest) J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
All references(85)
Other
accession IDs
MGD-MRK-13147, MGD-MRK-13156

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory