Pax4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pax4
paired box 4
MGI:97488

17 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pax4^{tm1(cre/ERT2)Sosa}/Pax4^{tm1(cre/ERT2)Sosa} Not Specified	abnormal pancreas morphology	J:130423
	absent pancreatic beta cells	J:130423
	absent pancreatic delta cells	J:130423
	decreased body size	J:130423
	postnatal lethality, complete penetrance	J:130423
Pax4^tm1.1Aman/Pax4^tm1.1Aman involves: 129S2/SvPas * C57BL/6 * SJL	no abnormal phenotype detected	J:192683
Pax4^{tm1b(EUCOMM)Hmgu}/Pax4⁺ C57BL/6N-Pax4^{tm1b(EUCOMM)Hmgu}/Ics	increased circulating alkaline phosphatase level	J:211773
	increased circulating total protein level	J:211773
	tremors	J:211773
Pax4^{tm1b(EUCOMM)Hmgu}/Pax4^{tm1b(EUCOMM)Hmgu} C57BL/6N-Pax4^{tm1b(EUCOMM)Hmgu}/Ics	preweaning lethality, complete penetrance	J:211773
Pax4^tm1Pgr/Pax4^tm1.1Aman Tg(CMV-cre)1Cgn/0 involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL	absent pancreatic beta cells	J:192683
	absent pancreatic delta cells	J:192683
	increased pancreatic alpha cell number	J:192683
	neonatal lethality, incomplete penetrance	J:192683
	postnatal lethality, incomplete penetrance	J:192683
Pax4^tm1Pgr/Pax4^tm1Pgr either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * NMRI)	abnormal pancreas secretion	J:39208
	abnormal pancreatic islet morphology	J:40439
	absent pancreatic delta cells	J:39028
	decreased pancreatic beta cell number	J:39208
	normal endocrine/exocrine gland phenotype	J:39208
	postnatal lethality, complete penetrance	J:39208
Pax4^tm1Pgr/Pax4^tm1Pgr involves: 129S1/Sv * 129X1/SvJ	abnormal pancreas morphology	J:130423
	absent pancreatic beta cells	J:130423
	absent pancreatic delta cells	J:130423

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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