Pax4^{tm1(cre/ERT2)Sosa}
Targeted Allele Detail

Summary

• Symbol: Pax4^{tm1(cre/ERT2)Sosa}
• Name: paired box 4; targeted mutation 1, Beatriz Sosa-Pineda
• MGI ID: MGI:3772207
• Synonyms: Pax4^T2, Pax4^{tm1(cre/ESR1)Sosa}
• Gene: Pax4 Location: Chr6:28442333-28449339 bp, - strand Genetic Position: Chr6, 11.99 cM
• Alliance: Pax4^{tm1(cre/ERT2)Sosa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130423
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Pax4^{tm1(cre/ERT2)Sosa} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax4 (MGI:97488)

• Mutation details: Exons 2 through 4, encoding the majority of the paired box domains, were replaced by the insertion of a cre/ERT2 and neo cassette. (J:130423)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax4 (mouse) Summary of all recombinase alleles driven by Pax4. Alliance mouse Pax4 gene page

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax4 Mutation: 26 strains or lines available

References

• Original: J:130423 Wang Q, et al., Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum. Dev Dyn. 2008 Jan;237(1):51-61
• All: 2 reference(s)