Reg3b MGI Mouse Gene Detail - MGI:97478 - regenerating islet-derived 3 beta

Reg3b Gene Detail

Symbol

Reg3b
Name

regenerating islet-derived 3 beta
Synonyms

Pap, PAP1, REG-III, RegIII (beta)

Feature Type

protein coding gene
IDs

MGI:97478
NCBI Gene: 18489
Gene Overview

MyGene.info: REG3A

Sequence Map

Chr6:78370657-78373466 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

2810 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 34.76 cM, cytoband C
Mapping Data

2 experiments

Human Ortholog

REG3A, regenerating family member 3 alpha

Vertebrate Orthologs

5

Human Ortholog

REG3A, regenerating family member 3 alpha
Orthology source: HomoloGene, HGNC
Synonyms

HIP, HIP/PAP, INGAP, PAP, PAP1, PAP-H, PBCGF, REG3, REG-III
Links

HGNC:8601

NCBI Gene ID: 5068

neXtProt AC: NX_Q06141

UniProt: Q06141
Chr Location

2p12; chr2:79157006-79159754 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 130506
1 human;1 mouse;1 rat;1 chimpanzee;1 macaque, rhesus
HCOP

human homology predictions: REG3A
Gene Tree

Reg3b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Reg3b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

Male homozygous mice exhibit impaired glucose tolerance.

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All GO Annotations

20
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

141
Tissues

64
cDNA Data

51
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Reg3b interacts with 28 markers (Mir10a, Mir23a, Mir23b, ...) View All

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All Sequences

27
RefSeq

2
UniProt

3
CCDS

CCDS20253.1
UniGene

2553

			Length	Strain/Species	Flank
genomic	OTTMUSG00000057462	VEGA Gene Model \| MGI Sequence Detail	2810	C57BL/6J	± kb
transcript	OTTMUST00000141334	VEGA \| MGI Sequence Detail	783	Not Applicable
polypeptide	OTTMUSP00000073885	VEGA \| MGI Sequence Detail	175	Not Applicable

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SNPs within 2kb

40 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000014393 regenerating islet-derived protein 3-beta

(term hierarchy)
InterPro Domains

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

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All nucleic 52

Genomic 1

cDNA 51

Microarray probesets 4

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MGD-MRK-13134, MGD-MRK-38452, MGI:109407

Summaries

All 38

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 5
Earliest

J:4201 Itoh T, et al., Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). Biochim Biophys Acta. 1993 Feb 20;1172(1-2):184-6
Latest

J:227930 Lorchner H, et al., Myocardial healing requires Reg3beta-dependent accumulation of macrophages in the ischemic heart. Nat Med. 2015 Apr;21(4):353-62

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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