Reg3b
Gene Detail

Symbol

Name
ID

Reg3b
regenerating islet-derived 3 beta
MGI:97478

Synonyms

Pap, PAP1, REG-III, RegIII (beta)

Feature Type

protein coding gene

Genetic Map

Chromosome 6
34.76 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:78370885-78373466 bp, + strand From NCBI annotation of GRCm38   2582 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:130506  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Reg3b

Human
homologs

Human Homolog		REG3A, regenerating islet-derived 3 alpha
NCBI Gene ID		5068
neXtProt AC		NX_Q06141
Human Synonyms		HIP, HIP/PAP, INGAP, PAP, PAP1, PAP-H, PBCGF, REG3, REG-III
Human Chr (Location)		2p12; chr2:79157006-79159754 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Genomic Mutations involving Reg3b (1)
Incidental mutations (data from Mutagenetix , APF )
 

Male homozygous mice exhibit impaired glucose tolerance.

 

Interactions

Reg3b interacts with 28 markers (Mir10a, Mir23a, Mir23b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (6 annotations)

Process	acute-phase response, defense response to Gram-negative bacterium, ...
Component	extracellular region
Function	carbohydrate binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (141)    Tissues (64)    Images (53)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	7
RNA in situ	134

cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(52) Genomic(1) cDNA(51)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000071356 (Evidence)
Entrez Gene	18489 (Evidence)
UniGene	2553
DFCI	TC1576607
DoTS	DT.534107
NIA Mouse Gene Index	U115859
Consensus CDS Project	CCDS20253.1
International Mouse Knockout Project Status	Reg3b

Sequences

Length	Strain/Species
genomic	18489	NCBI Gene Model | MGI Sequence Detail	2582	C57BL/6J
transcript	NM_011036	RefSeq | MGI Sequence Detail	759	C57BL/6
polypeptide	P35230	UniProt | EBI | MGI Sequence Detail	175	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(39 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001304	C-type lectin
InterPro	IPR018378	C-type lectin, conserved site
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
Protein Ontology	PR:000014393	regenerating islet-derived protein 3-beta

Graphical View of Protein Domain Structure

References

(Earliest) J:4201 Itoh T, et al., Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). Biochim Biophys Acta. 1993 Feb 20;1172(1-2):184-6
(Latest) J:186391 Tao J, et al., SEC23B is required for the maintenance of murine professional secretory tissues. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):E2001-9
All references(36)

Other
accession IDs

MGD-MRK-13134, MGD-MRK-38452, MGI:109407