Reg3b MGI Mouse Gene Detail - MGI:97478 - regenerating islet-derived 3 beta

Symbol

Reg3b
Name

regenerating islet-derived 3 beta
Synonyms

Pap, PAP1, REG-III, RegIII (beta)

Feature Type

protein coding gene
IDs

MGI:97478
NCBI Gene: 18489
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr6:78347868-78350449 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 34.76 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

162 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97478	protein coding gene	Chr6:78347640-78350449 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030893	protein coding gene	Chr6:79191459-79194268 (+)
A/J	MGP_AJ_G0030862	protein coding gene	Chr6:76110895-76113704 (+)
AKR/J	MGP_AKRJ_G0030790	protein coding gene	Chr6:78366173-78368982 (+)
BALB/cJ	MGP_BALBcJ_G0030872	protein coding gene	Chr6:76184287-76187096 (+)
C3H/HeJ	MGP_C3HHeJ_G0030838	protein coding gene	Chr6:105919972-105922781 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031332	protein coding gene	Chr6:81311388-81314197 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028519	protein coding gene	Chr6:74909853-74912652 (+)
CAST/EiJ	MGP_CASTEiJ_G0029980	protein coding gene	Chr6:78299550-78302360 (+)
CBA/J	MGP_CBAJ_G0030559	protein coding gene	Chr6:84515481-84518290 (+)
DBA/2J	MGP_DBA2J_G0030712	protein coding gene	Chr6:75483628-75486437 (+)
FVB/NJ	MGP_FVBNJ_G0030665	protein coding gene	Chr6:74751404-74754213 (+)
LP/J	MGP_LPJ_G0030791	protein coding gene	Chr6:79102527-79105336 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030701	protein coding gene	Chr6:88516922-88519731 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031356	protein coding gene	Chr6:78195471-78198280 (+)
PWK/PhJ	MGP_PWKPhJ_G0029696	protein coding gene	Chr6:74435789-74438598 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029524	protein coding gene	Chr6:77022585-77025385 (+)
WSB/EiJ	MGP_WSBEiJ_G0030062	protein coding gene	Chr6:78601901-78604710 (+)

Human Ortholog

REG3A, regenerating family member 3 alpha

Vertebrate Orthologs

11

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REG3A, regenerating family member 3 alpha
Synonyms

HIP, HIP/PAP, INGAP, PAP, PAP1, PAP-H, PBCGF, REG3, REG-III
Links

HGNC:8601

NCBI Gene ID: 5068

UniProt: Q06141
Chr Location

2p12; chr2:79157003-79159753 (-) GRCh38

Human Ortholog

REG3G, regenerating family member 3 gamma
Synonyms

LPPM429, PAP-1B, PAP1B, PAP IB, PAPIB, REG III, REG-III, UNQ429
Links

HGNC:29595

NCBI Gene ID: 130120

UniProt: Q6UW15
Chr Location

2p12; chr2:79025686-79028505 (+) GRCh38

MGI Vertebrate Homology

Reg3b stringent orthology
2 human;1 mouse;1 rat;8 zebrafish
HCOP

vertebrate homology predictions: REG3A, REG3G
Gene Tree

Reg3b

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

10
Spontaneous

1
Targeted

2
Transgenic

1
Genomic Mutations

2 involving Reg3b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male homozygous mice exhibit impaired glucose tolerance.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

64
cDNA Data

52
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS20253.1

Ensembl

ENSMUSG00000071356 (Evidence)
NCBI Gene

18489

			Length	Strain/Species	Flank
genomic	18489	NCBI Gene Model \| MGI Sequence Detail	2582	C57BL/6J	± kb
transcript	NM_011036	RefSeq \| MGI Sequence Detail	759	C57BL/6
polypeptide	P35230	UniProt \| EBI \| MGI Sequence Detail	175	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014393 regenerating islet-derived protein 3-beta

(term hierarchy)
InterPro Domains

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

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All nucleic 53

Genomic 1

cDNA 52

Microarray probesets 4

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MGD-MRK-13134, MGD-MRK-38452, MGI:109407

Summaries

All 73

Developmental Gene Expression 13

Gene Ontology 8

Phenotypes 19
Earliest

J:4201 Itoh T, et al., Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). Biochim Biophys Acta. 1993 Feb 20;1172(1-2):184-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Reg3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57184	Chr6:78347601-78347612 (+)	-261 bp
Tssr57185	Chr6:78347635-78347653 (+)	-224 bp
Tssr57186	Chr6:78347860-78347875 (+)	0 bp
Tssr57187	Chr6:78348025-78348033 (+)	161 bp
Tssr57188	Chr6:78348153-78348166 (+)	292 bp
Tssr57189	Chr6:78348172-78348189 (+)	313 bp
Tssr57190	Chr6:78348205-78348210 (+)	340 bp
Tssr57191	Chr6:78348773-78348809 (+)	923 bp
Tssr57192	Chr6:78348813-78348820 (+)	949 bp
Tssr57193	Chr6:78348831-78348849 (+)	972 bp
Tssr57194	Chr6:78349080-78349121 (+)	1,233 bp
Tssr57195	Chr6:78349123-78349167 (+)	1,277 bp
Tssr57196	Chr6:78349806-78349847 (+)	1,959 bp
Tssr57197	Chr6:78349850-78349878 (+)	1,996 bp
Tssr57198	Chr6:78350209-78350219 (+)	2,346 bp
Tssr57199	Chr6:78350336-78350347 (+)	2,474 bp
Tssr57200	Chr6:78350377-78350387 (+)	2,514 bp
Tssr57201	Chr6:78350398-78350405 (+)	2,534 bp
Tssr1896	Chr6:78350413-78350420 (+)	2,549 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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