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Reg3b
Gene Detail
Symbol

Name
ID
Reg3b
regenerating islet-derived 3 beta
MGI:97478
Synonyms
Pap, PAP1, REG-III, RegIII (beta)
Feature Type
protein coding gene
Genetic Map
Chromosome 6
34.76 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:78370885-78373466 bp, + strand
From NCBI annotation of GRCm38

  2582 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130506  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Reg3b

Human
homologs
Human Homolog REG3A, regenerating islet-derived 3 alpha
NCBI Gene ID 5068
neXtProt AC  NX_Q06141
Human Synonyms  HIP, HIP/PAP, INGAP, PAP, PAP1, PAP-H, PBCGF, REG3, REG-III
Human Chr (Location)  2p12; chr2:79157006-79159754 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Male homozygous mice exhibit impaired glucose tolerance.
 
Interactions
Reg3b interacts with 28 markers (Mir10a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process acute-phase response, defense response to Gram-negative bacterium, ...
Component extracellular region
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (141)    Tissues (64)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 134
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) Genomic(1) cDNA(51)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000071356 (Evidence)
Entrez Gene18489 (Evidence)
UniGene2553
DFCITC1576607
DoTSDT.534107
NIA Mouse Gene IndexU115859
Consensus CDS ProjectCCDS20253.1
International Mouse Knockout Project StatusReg3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18489 NCBI Gene Model | MGI Sequence Detail 2582 C57BL/6J ±  kb
transcript NM_011036 RefSeq | MGI Sequence Detail 759 C57BL/6 
polypeptide P35230 UniProt | EBI | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000014393 regenerating islet-derived protein 3-beta
Graphical View of Protein Domain Structure
References
(Earliest) J:4201 Itoh T, et al., Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). Biochim Biophys Acta. 1993 Feb 20;1172(1-2):184-6
(Latest) J:186391 Tao J, et al., SEC23B is required for the maintenance of murine professional secretory tissues. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):E2001-9
All references(36)
Other
accession IDs
MGD-MRK-13134, MGD-MRK-38452, MGI:109407

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory