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Odc1
Gene Detail
Symbol

Name
ID
Odc1
ornithine decarboxylase, structural 1
MGI:97402
STS
Synonyms
ODC
Feature Type
protein coding gene
Genetic Map
Chromosome 12
8.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr12:17544873-17551502 bp, + strand
From NCBI annotation of GRCm38

  6630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ODC1
Protein SuperFamily: ornithine decarboxylase
Gene Tree: Odc1

Human
homologs
ODC1, ornithine decarboxylase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4953
neXtProt AC: NX_P11926

Human Synonyms: ODC

Human Chr (Location): 2p25; chr2:10440371-10448554 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(11) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die prior to gastrulation.
 
Human Diseases Modeled in Mice Using Odc1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Odc1 interacts with 169 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process kidney development, polyamine biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function carboxy-lyase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (139)    Tissues (129)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 123
In situ reporter (knock in) 2
Western blot 6
RT-PCR 6
cDNA source data(27)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase odc1 ; ZFIN odc1    NEW 
Molecular
reagents
All nucleic(38) Genomic(6) cDNA(28) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000011179 (Evidence)
Entrez Gene 18263 (Evidence)
DFCI TC1573105, TC1676513
DoTS DT.101392287, DT.101738463, DT.40162581, DT.537268
NIA Mouse Gene Index U005821, U013795, U056224, U068130, U076823, U078885, U109938, U127084, U134033, U163034, U365943
EC 4.1.1.17
PDB 7ODC
Consensus CDS Project CCDS25829.1
International Mouse Phenotyping Consortium Status Odc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18263 NCBI Gene Model | MGI Sequence Detail 6630 C57BL/6J ±  kb
transcript NM_013614 RefSeq | MGI Sequence Detail 2547 Not Specified 
polypeptide P00860 UniProt | EBI | MGI Sequence Detail 461 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009006 Alanine racemase/group IV decarboxylase, C-terminal
InterPro IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site
InterPro IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal
InterPro IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal
InterPro IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site
InterPro IPR000183 Ornithine/DAP/Arg decarboxylase
InterPro IPR002433 Ornithine decarboxylase
Protein Ontology PR:000011596 ornithine decarboxylase
Graphical View of Protein Domain Structure
References
(Earliest) J:7845 Janne OA, et al., Ornithine decarboxylase mRNA in mouse kidney: a low abundancy gene product regulated by androgens with rapid kinetics. Ann N Y Acad Sci. 1984;438:72-84
(Latest) J:217679 Washkowitz AJ, et al., Mga is essential for the survival of pluripotent cells during peri-implantation development. Development. 2015 Jan 1;142(1):31-40
All references(124)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12979

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory