Odc1
Gene Detail

Symbol Name ID

Odc1 ornithine decarboxylase, structural 1 MGI:97402

STS

D12Nds11

Synonyms

ODC

Feature Type

protein coding gene

Genetic Map

Chromosome 12

8.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)

Sequence Map

Chr12:17544873-17551502 bp, + strand From NCBI annotation of GRCm38   6630 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ornithine decarboxylase
Gene Tree: Odc1

Human homologs

Human Homolog		ODC1, ornithine decarboxylase 1
NCBI Gene ID		4953
neXtProt AC		NX_P11926
Human Synonyms		ODC
Human Chr (Location)		2p25; chr2:10580508-10588453 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ODC1

Alleles and phenotypes

All alleles(14) : Targeted(3) Gene trapped(11)
 

Homozygous null embryos die prior to gastrulation.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	kidney development, metabolic process, ...
Component	cytosol
Function	carboxy-lyase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (139)    Tissues (129)    Images (27)
Theiler Stages: 4, 11, 13, 15, 19, 22, 23, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	123
In situ reporter (knock in)	2
Western blot	6
RT-PCR	6

cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(6) cDNA(28) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000011179 (Evidence)
Entrez Gene	18263 (Evidence)
DFCI	TC1573105, TC1676513
DoTS	DT.101392287, DT.101738463, DT.40162581, DT.537268
NIA Mouse Gene Index	U005821, U013795, U056224, U068130, U076823, U078885, U109938, U127084, U134033, U163034, U365943
EC	4.1.1.17
PDB	7ODC
Consensus CDS Project	CCDS25829.1
International Mouse Knockout Project Status	Odc1

Sequences

Length	Strain/Species
genomic	18263	NCBI Gene Model | MGI Sequence Detail	6630	C57BL/6J
transcript	NM_013614	RefSeq | MGI Sequence Detail	2547	Not Specified
polypeptide	P00860	UniProt | EBI | MGI Sequence Detail	461	Not Applicable

All sequences(73) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs(41 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal
InterPro	IPR022657	Orn/DAP/Arg decarboxylase 2, conserved site
InterPro	IPR022643	Orn/DAP/Arg decarboxylase 2, C-terminal
InterPro	IPR022644	Orn/DAP/Arg decarboxylase 2, N-terminal
InterPro	IPR022653	Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site
InterPro	IPR000183	Ornithine/DAP/Arg decarboxylase
InterPro	IPR002433	Ornithine decarboxylase
Protein Ontology	PR:000011596	ornithine decarboxylase

Graphical View of Protein Domain Structure

References

(Earliest) J:7845 Janne OA, et al., Ornithine decarboxylase mRNA in mouse kidney: a low abundancy gene product regulated by androgens with rapid kinetics. Ann N Y Acad Sci. 1984;438:72-84
(Latest) J:182065 Lee NK, et al., Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation. Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E172-9
All references(120)

Other accession IDs

MGD-MRK-12979