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Oat Gene Detail
Summary
  • Symbol
    Oat
  • Name
    ornithine aminotransferase
  • Synonyms
    rhg
  • Feature Type
    protein coding gene
  • IDs
    MGI:97394
    NCBI Gene: 18242
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132557478-132576398 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 76.30 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97394
protein coding gene Chr7:132557475-132576398 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033112
protein coding gene Chr7:137252713-137272428 (-)
A/J MGP_AJ_G0033094
protein coding gene Chr7:133475988-133494911 (-)
AKR/J MGP_AKRJ_G0033026
protein coding gene Chr7:137037409-137056544 (-)
BALB/cJ MGP_BALBcJ_G0033095
protein coding gene Chr7:133158971-133177894 (-)
C3H/HeJ MGP_C3HHeJ_G0032809
protein coding gene Chr7:136870691-136889641 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033606
protein coding gene Chr7:142487582-142507930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030577
protein coding gene Chr7:134754880-134774202 (-)
CAST/EiJ MGP_CASTEiJ_G0032139
protein coding gene Chr7:128770334-128789367 (-)
CBA/J MGP_CBAJ_G0032782
protein coding gene Chr7:147313373-147336580 (-)
DBA/2J MGP_DBA2J_G0032934
protein coding gene Chr7:131489746-131508602 (-)
FVB/NJ MGP_FVBNJ_G0032887
protein coding gene Chr7:131313675-131332878 (-)
LP/J MGP_LPJ_G0033028
protein coding gene Chr7:138754072-138774808 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032919
protein coding gene Chr7:148247147-148266144 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033626
protein coding gene Chr7:136018306-136038045 (-)
PWK/PhJ MGP_PWKPhJ_G0031845
protein coding gene Chr7:124510601-124529627 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031691
protein coding gene Chr7:122809876-122831594 (-)
WSB/EiJ MGP_WSBEiJ_G0032250
protein coding gene Chr7:136924245-136945197 (-)



Homology
more
  • Human Ortholog
    OAT, ornithine aminotransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OAT, ornithine aminotransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GACR, HOGA, OATASE, OKT
  • Links
    NCBI Gene ID: 4942
    neXtProt AC: NX_P04181
    UniProt: P04181

  • Chr Location
    10q26.13; chr10:124397303-124418976 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Oat mouse models; 1 with human OAT associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    5 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null mutants show neonatal hypoornithinemia and increased mortality prevented by administering arginine. Homozygotes for a spontaneous G353A point mutation have neonatal hypoornithinemia, adult hyperornithinemia, growth retardation, retarded fur development, cataracts, and retinal degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030934 Ensembl Gene Model | MGI Sequence Detail 18921 C57BL/6J ±  kb
    transcript ENSMUST00000084500 Ensembl | MGI Sequence Detail 2152 Not Applicable  
    polypeptide ENSMUSP00000081544 Ensembl | MGI Sequence Detail 439 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 352
      Genomic 3
      cDNA 349

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12964, MGD-MRK-13865, MGI:2141877, MGI:97913
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:4833 O'Donnell JJ, et al., Ornithine aminotransferase (OAT) maps to human chromosome 10 and mouse chromosome 7. Cytogenet Cell Genet. 1985;40:716
    • Latest
      J:237185 Palanza KM, et al., Auxotrophy-Based detection of Hyperornithinemia in mouse blood and urine. J Inborn Errors of Metab and Screening. 2016;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory