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Oat
Gene Detail
Symbol

Name
ID
Oat
ornithine aminotransferase
MGI:97394
Synonyms
rhg
Feature Type
protein coding gene
Genetic Map
Chromosome 7
76.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr7:132557475-132576398 bp, - strand
From NCBI annotation of GRCm38

  18924 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Transaminase_4ab_Lys_Orn
Gene Tree: Oat

Human
homologs
Human Homolog OAT, ornithine aminotransferase
NCBI Gene ID 4942
neXtProt AC  NX_P04181
Human Synonyms  GACR, HOGA, OATASE, OKT
Human Chr (Location)  10q26; chr10:124397303-124418976 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human OAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants show neonatal hypoornithinemia and increased mortality prevented by administering arginine. Homozygotes for a spontaneous G353A point mutation have neonatal hypoornithinemia, adult hyperornithinemia, growth retardation, retarded fur development, cataracts, and retinal degeneration.
 
Human Diseases Modeled Using Mouse Oat (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Oat interacts with 131 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process protein hexamerization
Component cytoplasm, mitochondrion
Function catalytic activity, ornithine-oxo-acid transaminase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(346)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(351) Genomic(3) cDNA(348)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030934 (Evidence)
Entrez Gene18242 (Evidence)
UniGene13694
DFCITC1573551, TC1636267
DoTSDT.101151086, DT.537288
NIA Mouse Gene IndexU029352
EC2.6.1.13
Consensus CDS ProjectCCDS21923.1
International Mouse Knockout Project StatusOat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18242 NCBI Gene Model | MGI Sequence Detail 18924 C57BL/6J ±  kb
transcript NM_016978 RefSeq | MGI Sequence Detail 2155 C57BL/6 
polypeptide P29758 UniProt | EBI | MGI Sequence Detail 439 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005814 Aminotransferase class-III
InterPro IPR010164 Ornithine aminotransferase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000011578 ornithine aminotransferase, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:13745 Fox S, et al., Retarded hair growth (rhg). Mouse News Lett. 1978;58:47
(Latest) J:213842 Bisaillon JJ, et al., The retarded hair growth () mutation in mice is an allele of ornithine aminotransferase (). Mol Genet Metab Rep. 2014;1:378-390
All references(54)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12964, MGD-MRK-13865, MGI:2141877, MGI:97913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory