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Ntsr1 Gene Detail
Summary
  • Symbol
    Ntsr1
  • Name
    neurotensin receptor 1
  • Synonyms
    NT-1R, NTR1, NTR-1, Ntsr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97386
    NCBI Gene: 18216
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180141769-180186772 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.04 cM, cytoband H1-H4
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97386
protein coding gene Chr2:180141769-180186773 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026995
protein coding gene Chr2:187020202-187065329 (+)
A/J MGP_AJ_G0026961
protein coding gene Chr2:179342024-179387239 (+)
AKR/J MGP_AKRJ_G0026931
protein coding gene Chr2:184721020-184766513 (+)
BALB/cJ MGP_BALBcJ_G0026970
protein coding gene Chr2:179805168-179850473 (+)
C3H/HeJ MGP_C3HHeJ_G0026711
protein coding gene Chr2:185054902-185116033 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027416
protein coding gene Chr2:192421154-192470765 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024781
protein coding gene Chr2:170035079-170079225 (+)
CAST/EiJ MGP_CASTEiJ_G0026170
protein coding gene Chr2:183303581-183349896 (+)
CBA/J MGP_CBAJ_G0026688
protein coding gene Chr2:199420833-199472848 (+)
DBA/2J MGP_DBA2J_G0026826
protein coding gene Chr2:178439090-178484159 (+)
FVB/NJ MGP_FVBNJ_G0026792
protein coding gene Chr2:177050276-177096892 (+)
LP/J MGP_LPJ_G0026927
protein coding gene Chr2:187024364-187075160 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026811
protein coding gene Chr2:202020043-202071898 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027475
protein coding gene Chr2:184672845-184719483 (+)
PWK/PhJ MGP_PWKPhJ_G0025906
protein coding gene Chr2:175949912-175995395 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025706
protein coding gene Chr2:181167735-181214652 (+)
WSB/EiJ MGP_WSBEiJ_G0026242
protein coding gene Chr2:185652926-185700720 (+)



Homology
more
  • Human Ortholog
    NTSR1, neurotensin receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTSR1, neurotensin receptor 1
  • Synonyms
    NTR
  • Links
    NCBI Gene ID: 4923
    neXtProt AC: NX_P30989
    UniProt: P30989

  • Chr Location
    20q13.33; chr20:62708836-62762771 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human NTSR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 6 alleles in 7 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice deficient for this marker have normal baseline prepulse inhibition responses and acoustic startle responses. Mice are heavier, eat more, and have lower body temperatures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18216 NCBI Gene Model | MGI Sequence Detail 45004 C57BL/6J ±  kb
    transcript NM_018766 RefSeq | MGI Sequence Detail 3916 Not Specified  
    polypeptide O88319 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12945
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 29
    • Earliest
      J:18220 Laurent P, et al., Chromosomal localization of mouse and human neurotensin receptor genes. Mamm Genome. 1994 May;5(5):303-6
    • Latest
      J:335213 Ehrlich AT, et al., Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice. Front Cell Neurosci. 2022;16:1076599

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory