Ntsr1
Gene Detail

Symbol Name ID

Ntsr1 neurotensin receptor 1 MGI:97386

Synonyms

NT-1R, NTR1, NTR-1, Ntsr1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

103.04 cM, cytoband H1-H4
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:180499976-180544980 bp, + strand From VEGA annotation of GRCm38   45005 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ntsr1 ± 2 cM)

Protein SuperFamily: neurotensin receptor
Gene Tree: Ntsr1

Human ortholog

NTSR1 neurotensin receptor 1 (high affinity) NCBI Gene ID 4923
Human Synonyms: NTR
Human Chr20:61340189-61394123 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Mice deficient for this marker have normal baseline prepulse inhibition responses and acoustic startle responses. Mice are heavier, eat more, and have lower body temperatures.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	adult locomotory behavior, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled neurotensin receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (112)    Tissues (71)    Images (13)
Theiler Stages: 19, 23, 24, 28

Assay Type	Results
RNA in situ	44
In situ reporter (knock in)	29
RT-PCR	39

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(1) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016330 (Evidence)
Ensembl Gene Model	ENSMUSG00000027568 (Evidence)
Entrez Gene	18216 (Evidence)
UniGene	301712
DFCI	TC1589274
DoTS	DT.55210854
NIA Mouse Gene Index	U002956
Consensus CDS Project	CCDS17177.1
International Mouse Knockout Project Status	Ntsr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016330	VEGA Gene Model | MGI Sequence Detail	45005	C57BL/6J
transcript	OTTMUST00000039236	VEGA | MGI Sequence Detail	3917	Not Applicable
polypeptide	OTTMUSP00000017536	VEGA | MGI Sequence Detail	424	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(247 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR003984	Neurotensin receptor
InterPro	IPR003985	Neurotensin type 1 receptor
Protein Ontology	PR:000001627	neurotensin receptor 1

References

(Earliest) J:18220 Laurent P, et al., Chromosomal localization of mouse and human neurotensin receptor genes. Mamm Genome. 1994 May;5(5):303-6
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(56)

Other accession IDs

MGD-MRK-12945