About   Help   FAQ
Ntsr1
Gene Detail
Symbol

Name
ID
Ntsr1
neurotensin receptor 1
MGI:97386
Synonyms
NT-1R, NTR1, NTR-1, Ntsr1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.04 cM, cytoband H1-H4
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:180499976-180544980 bp, + strand
From VEGA annotation of GRCm38

  45005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68261  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NTSR1
Protein SuperFamily: neurotensin receptor
Gene Tree: Ntsr1

Human
homologs
NTSR1, neurotensin receptor 1 (high affinity)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4923
neXtProt AC: NX_P30989

Human Synonyms: NTR

Human Chr (Location): 20q13; chr20:62708783-62762771 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice deficient for this marker have normal baseline prepulse inhibition responses and acoustic startle responses. Mice are heavier, eat more, and have lower body temperatures.
 
Interactions
Ntsr1 interacts with 241 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process adult locomotory behavior, D-aspartate import, ...
Component axon, axon terminus, ...
Function G-protein coupled neurotensin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (112)    Tissues (71)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
In situ reporter (knock in) 29
RT-PCR 39
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016330 (Evidence)
Ensembl Gene Model ENSMUSG00000027568 (Evidence)
Entrez Gene 18216 (Evidence)
UniGene 301712
DFCI TC1589274
DoTS DT.55210854
NIA Mouse Gene Index U002956
Consensus CDS Project CCDS17177.1
International Mouse Phenotyping Consortium Status Ntsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016330 VEGA Gene Model | MGI Sequence Detail 45005 C57BL/6J ±  kb
transcript OTTMUST00000039236 VEGA | MGI Sequence Detail 3917 Not Applicable 
polypeptide OTTMUSP00000017536 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR003984 Neurotensin receptor
InterPro IPR003985 Neurotensin type 1 receptor
Protein Ontology PR:000001627 neurotensin receptor type 1
References
(Earliest) J:18220 Laurent P, et al., Chromosomal localization of mouse and human neurotensin receptor genes. Mamm Genome. 1994 May;5(5):303-6
(Latest) J:216582 Bakirtzi K, et al., The Neurotensin-HIF-1alpha-VEGFalpha Axis Orchestrates Hypoxia, Colonic Inflammation, and Intestinal Angiogenesis. Am J Pathol. 2014 Dec;184(12):3405-14
All references(58)
Other
accession IDs
MGD-MRK-12945

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory