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Ntsr1
Gene Detail
 Symbol
Name
ID
Ntsr1
neurotensin receptor 1
MGI:97386
Synonyms NT-1R, NTR1, NTR-1, Ntsr1
Feature Type protein coding gene
Genetic Map
Chromosome 2
103.04 cM, cytoband H1-H4
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:180499976-180544980 bp, + strand
From VEGA annotation of GRCm38

  45005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68261  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neurotensin receptor
Gene Tree: Ntsr1

Human
homologs
Human Homolog NTSR1, neurotensin receptor 1 (high affinity)
NCBI Gene ID 4923
neXtProt AC  NX_P30989
Human Synonyms  NTR
Human Chr (Location)  20q13; chr20:62708837-62762771 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice deficient for this marker have normal baseline prepulse inhibition responses and acoustic startle responses. Mice are heavier, eat more, and have lower body temperatures.
 
Interactions
Ntsr1 interacts with 242 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process adult locomotory behavior, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function G-protein coupled neurotensin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (112)    Tissues (71)    Images (13)
Theiler Stages: 19, 23, 24, 28
Assay TypeResults
RNA in situ 44
In situ reporter (knock in) 29
RT-PCR 39
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016330 (Evidence)
Ensembl Gene ModelENSMUSG00000027568 (Evidence)
Entrez Gene18216 (Evidence)
UniGene301712
DFCITC1589274
DoTSDT.55210854
NIA Mouse Gene IndexU002956
Consensus CDS ProjectCCDS17177.1
International Mouse Knockout Project StatusNtsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016330 VEGA Gene Model | MGI Sequence Detail 45005 C57BL/6J ±  kb
transcript OTTMUST00000039236 VEGA | MGI Sequence Detail 3917 Not Applicable 
polypeptide OTTMUSP00000017536 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR003984 Neurotensin receptor
InterPro IPR003985 Neurotensin type 1 receptor
Protein Ontology PR:000001627 neurotensin receptor type 1
References (Earliest) J:18220 Laurent P, et al., Chromosomal localization of mouse and human neurotensin receptor genes. Mamm Genome. 1994 May;5(5):303-6
(Latest) J:199787 Saurat N, et al., Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development. Neural Dev. 2013;8:14
All references(58)
Other
accession IDs
MGD-MRK-12945

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory