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Ntf5 Gene Detail
Summary
  • Symbol
    Ntf5
  • Name
    neurotrophin 5
  • Synonyms
    2900040K06Rik, neurotrophin-4, NT4, NT-4, NT4/5, Ntf4, Ntf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:97381
    NCBI Gene: 78405
  • Gene Overview
    MyGene.info: NTF4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:45413695-45417179 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3485 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.30 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NTF4, neurotrophin 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NTF4, neurotrophin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLC10, GLC1O, NT4, NT-4, NT-4/5, NT5, NT-5, NTF5
  • Links
    NCBI Gene ID: 4909
    neXtProt AC: NX_P34130
    UniProt: P34130

  • Chr Location
    19q13.33; chr19:49058284-49065076 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NTF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit sensory neuron deficits. One nullizygous mutation causes loss of BDNF-dependent neural crest-derived sensory neurons and impaired coordination, while another leads to reduced neuron apoptosis, thick skin, and altered hair cycle control.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059407 VEGA Gene Model | MGI Sequence Detail 3485 C57BL/6J ±  kb
    transcript OTTMUST00000145815 VEGA | MGI Sequence Detail 1963 Not Applicable  
    polypeptide OTTMUSP00000075967 VEGA | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      7 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 10
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-12938, MGD-MRK-12940, MGD-MRK-24018, MGI:103152, MGI:1925655, MGI:2141976
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 21
      Gene Ontology 10
      Phenotypes 59
    • Earliest
      J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
    • Latest
      J:264123 Tanimizu N, et al., Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver. Development. 2018 Apr 25;145(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory