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Ntf5
Gene Detail
 Symbol
Name
ID
Ntf5
neurotrophin 5
MGI:97381
Synonyms 2900040K06Rik, neurotrophin-4, NT4, NT-4, NT4/5, Ntf4, Ntf-5
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:45413695-45417178 bp, + strand
From Ensembl annotation of GRCm38

  3484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ntf5

Human
homologs
Human Homolog NTF4, neurotrophin 4
NCBI Gene ID 4909
neXtProt AC  NX_P34130
Human Synonyms  GLC10, GLC1O, NT4, NT-4, NT-4/5, NT5, NT-5, NTF5
Human Chr (Location)  19q13.3; chr19:49061066-49065076 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NTF4
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
 
Nullizygous mice exhibit sensory neuron deficits. One nullizygous mutation causes loss of BDNF-dependent neural crest-derived sensory neurons and impaired coordination, while another leads to reduced neuron apoptosis, thick skin, and altered hair cycle control.
 
Interactions
Ntf5 interacts with 127 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process adult locomotory behavior, epidermis development, ...
Component extracellular region
Function growth factor activity, neurotrophin p75 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (34)    Tissues (21)    Images (4)
Theiler Stages: 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 24
RT-PCR 10
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(2) cDNA(8) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000074121 (Evidence)
Entrez Gene78405 (Evidence)
UniGene20344
DFCITC1587504
DoTSDT.40139914
NIA Mouse Gene IndexU008073
Consensus CDS ProjectCCDS21241.1
International Mouse Knockout Project StatusNtf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074121 Ensembl Gene Model | MGI Sequence Detail 3484 C57BL/6J ±  kb
transcript ENSMUST00000058879 Ensembl | MGI Sequence Detail 1962 Not Applicable 
polypeptide ENSMUSP00000057916 Ensembl | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019846 Nerve growth factor conserved site
InterPro IPR020408 Nerve growth factor-like
InterPro IPR002072 Nerve growth factor-related
InterPro IPR020432 Neurotrophin-4
Protein Ontology PR:000011460 neurotrophin-4
References (Earliest) J:14649 Sutter A, et al., Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem. 1979 Jul 10;254(13):5972-82
(Latest) J:210382 Aven L, et al., An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb;28(2):897-907
All references(113)
Other
accession IDs
MGD-MRK-12938, MGD-MRK-12940, MGD-MRK-24018, MGI:103152, MGI:1925655, MGI:2141976

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory