Ntf5
Gene Detail

Symbol Name ID

Ntf5 neurotrophin 5 MGI:97381

Synonyms

2900040K06Rik, neurotrophin-4, NT4, NT-4, NT4/5, Ntf4, Ntf-5

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:45413695-45417178 bp, + strand From Ensembl annotation of GRCm38   3484 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ntf5

Human homologs

Human Homolog		NTF4, neurotrophin 4
NCBI Gene ID		4909
neXtProt AC		NX_P34130
Human Synonyms		GLC10, GLC1O, NT4, NT-4, NT-4/5, NT5, NT-5, NTF5
Human Chr (Location)		19q13.3; chr19:49564397-49567124 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NTF4

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Nullizygous mice exhibit sensory neuron deficits. One nullizygous mutation causes loss of BDNF-dependent neural crest-derived sensory neurons and impaired coordination, while another leads to reduced neuron apoptosis, thick skin, and altered hair cycle control.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	adult locomotory behavior, epidermis development, ...
Component	extracellular region
Function	growth factor activity, neurotrophin p75 receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (34)    Tissues (20)    Images (4)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	24
RT-PCR	10

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(2) cDNA(8) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000074121 (Evidence)
Entrez Gene	78405 (Evidence)
UniGene	20344
DFCI	TC1587504
DoTS	DT.40139914
NIA Mouse Gene Index	U008073
Consensus CDS Project	CCDS21241.1
International Mouse Knockout Project Status	Ntf5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000074121	Ensembl Gene Model | MGI Sequence Detail	3484	C57BL/6J
transcript	ENSMUST00000058879	Ensembl | MGI Sequence Detail	1962	Not Applicable
polypeptide	ENSMUSP00000057916	Ensembl | MGI Sequence Detail	209	Not Applicable

All sequences(13) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019846	Nerve growth factor conserved site
InterPro	IPR020408	Nerve growth factor-like
InterPro	IPR002072	Nerve growth factor-related
InterPro	IPR020432	Neurotrophin-4
Protein Ontology	PR:000011460	neurotrophin-4

References

(Earliest) J:14649 Sutter A, et al., Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem. 1979 Jul 10;254(13):5972-82
(Latest) J:186161 Hu B, et al., Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
All references(106)

Other accession IDs

MGD-MRK-12938, MGD-MRK-12940, MGD-MRK-24018, MGI:103152, MGI:1925655, MGI:2141976