About   Help   FAQ
Ntf5
Gene Detail
Symbol

Name
ID
Ntf5
neurotrophin 5
MGI:97381
Synonyms
2900040K06Rik, neurotrophin-4, NT4, NT-4, NT4/5, Ntf4, Ntf-5
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:45413695-45417178 bp, + strand
From Ensembl annotation of GRCm38

  3484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: NTF4
Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ntf5

Human
homologs
NTF4, neurotrophin 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4909
neXtProt AC: NX_P34130

Human Synonyms: GLC10, GLC1O, NT4, NT-4, NT-4/5, NT5, NT-5, NTF5

Human Chr (Location): 19q13.3; chr19:49061080-49065076 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NTF4

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
 
Nullizygous mice exhibit sensory neuron deficits. One nullizygous mutation causes loss of BDNF-dependent neural crest-derived sensory neurons and impaired coordination, while another leads to reduced neuron apoptosis, thick skin, and altered hair cycle control.
 
Interactions
Ntf5 interacts with 127 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (18 records)
Data Summary: Results (35)    Tissues (22)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 1
RT-PCR 10
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ntf4    NEW 
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(9) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000074121 (Evidence)
Entrez Gene 78405 (Evidence)
UniGene 20344
DFCI TC1587504
DoTS DT.40139914
NIA Mouse Gene Index U008073
Consensus CDS Project CCDS21241.1
International Mouse Phenotyping Consortium Status Ntf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074121 Ensembl Gene Model | MGI Sequence Detail 3484 C57BL/6J ±  kb
transcript ENSMUST00000058879 Ensembl | MGI Sequence Detail 1962 Not Applicable 
polypeptide ENSMUSP00000057916 Ensembl | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029034 Cystine-knot cytokine
InterPro IPR019846 Nerve growth factor conserved site
InterPro IPR020408 Nerve growth factor-like
InterPro IPR002072 Nerve growth factor-related
InterPro IPR020432 Neurotrophin-4
Protein Ontology PR:000011460 neurotrophin-4
References
(Earliest) J:14649 Sutter A, et al., Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem. 1979 Jul 10;254(13):5972-82
(Latest) J:218012 Rutlin M, et al., The cellular and molecular basis of direction selectivity of Adelta-LTMRs. Cell. 2014 Dec 18;159(7):1640-51
All references(114)
Other
accession IDs
MGD-MRK-12938, MGD-MRK-12940, MGD-MRK-24018, MGI:103152, MGI:1925655, MGI:2141976

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory