Ntf3
Gene Detail

Symbol Name ID

Ntf3 neurotrophin 3 MGI:97380

Synonyms

NT3, NT-3, Ntf-3

Feature Type

protein coding gene

Genetic Map

Chromosome 6

60.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:126101413-126166744 bp, - strand From Ensembl annotation of GRCm38   65332 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1896  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ntf3

Human homologs

Human Homolog		NTF3, neurotrophin 3
NCBI Gene ID		4908
neXtProt AC		NX_P20783
Human Synonyms		HDNF, NGF2, NGF-2, NT3
Human Chr (Location)		12p13; chr12:5541280-5604465 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(12)
 

Homozygotes for targeted null mutations exhibit loss of peripheral sensory and sympathetic neurons, lack of spinal propioceptive afferents and their sense organs, impaired suckling and movement, and postnatal lethality. Heterozygotes show mild defects.

 
Human Diseases Modeled Using Mouse Ntf3 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	activation of MAPK activity, activation of protein kinase B activity, ...
Component	cytoplasmic membrane-bounded vesicle, extracellular region
Function	chemoattractant activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (59 records)
Data Summary: Results (199)    Tissues (126)    Images (51)
Theiler Stages: 17, 18, 20, 21, 22, 23, 24, 26

Assay Type	Results
RNA in situ	193
Northern blot	6

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(6) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000049107 (Evidence)
Entrez Gene	18205 (Evidence)
UniGene	267570
DFCI	TC1584089, TC1687539
DoTS	DT.50316279, DT.94294599, DT.99849442
NIA Mouse Gene Index	U027873
Consensus CDS Project	CCDS20553.1, CCDS51914.1
International Mouse Knockout Project Status	Ntf3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000049107	Ensembl Gene Model | MGI Sequence Detail	65332	C57BL/6J
transcript	ENSMUST00000112244	Ensembl | MGI Sequence Detail	1427	Not Applicable
polypeptide	ENSMUSP00000107863	Ensembl | MGI Sequence Detail	271	Not Applicable

All sequences(28) RefSeq(6) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(199 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019846	Nerve growth factor conserved site
InterPro	IPR020408	Nerve growth factor-like
InterPro	IPR002072	Nerve growth factor-related
InterPro	IPR015578	Neurotrophin-3
Protein Ontology	PR:000011459	neurotrophin-3

References

(Earliest) J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
(Latest) J:191993 Lee J, et al., Scaling proprioceptor gene transcription by retrograde NT3 signaling. PLoS One. 2012;7(9):e45551
All references(213)

Other accession IDs

MGD-MRK-12937, MGD-MRK-12939, MGI:1353664, MGI:2141474