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Ntf3
Gene Detail
 Symbol
Name
ID
Ntf3
neurotrophin 3
MGI:97380
Synonyms NT3, NT-3, Ntf-3
Feature Type protein coding gene
Genetic Map
Chromosome 6
60.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:126101413-126166744 bp, - strand
From Ensembl annotation of GRCm38

  65332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1896  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ntf3

Human
homologs
Human Homolog NTF3, neurotrophin 3
NCBI Gene ID 4908
neXtProt AC  NX_P20783
Human Synonyms  HDNF, NGF2, NGF-2, NT3, NT-3
Human Chr (Location)  12p13; chr12:5432114-5495299 (+)  GRCh38
Alleles
and
phenotypes
All alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit loss of peripheral sensory and sympathetic neurons, lack of spinal propioceptive afferents and their sense organs, impaired suckling and movement, and postnatal lethality. Heterozygotes show mild defects.
 
Human Diseases Modeled Using Mouse Ntf3 (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process activation of MAPK activity, activation of protein kinase B activity, ...
Component cytoplasmic membrane-bounded vesicle, extracellular region
Function chemoattractant activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (219)    Tissues (139)    Images (52)
Theiler Stages: 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 193
In situ reporter (knock in) 15
Northern blot 9
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) Genomic(6) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000049107 (Evidence)
Entrez Gene18205 (Evidence)
UniGene267570
DFCITC1584089, TC1687539
DoTSDT.50316279, DT.94294599, DT.99849442
NIA Mouse Gene IndexU027873
Consensus CDS ProjectCCDS20553.1, CCDS51914.1
International Mouse Knockout Project StatusNtf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049107 Ensembl Gene Model | MGI Sequence Detail 65332 C57BL/6J ±  kb
transcript ENSMUST00000112244 Ensembl | MGI Sequence Detail 1427 Not Applicable 
polypeptide ENSMUSP00000107863 Ensembl | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(10) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019846 Nerve growth factor conserved site
InterPro IPR020408 Nerve growth factor-like
InterPro IPR002072 Nerve growth factor-related
InterPro IPR015578 Neurotrophin-3
Protein Ontology PR:000011459 neurotrophin-3
References (Earliest) J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
(Latest) J:201812 Fox EA, et al., Loss of Neurotrophin-3 from Smooth Muscle Disrupts Vagal Gastrointestinal Afferent Signaling and Satiation. Am J Physiol Regul Integr Comp Physiol. 2013 Sep 25;
All references(220)
Other
accession IDs
MGD-MRK-12937, MGD-MRK-12939, MGI:1353664, MGI:2141474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory