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Ntf3 Gene Detail
Summary
  • Symbol
    Ntf3
  • Name
    neurotrophin 3
  • Synonyms
    NT3, NT-3, Ntf-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97380
    NCBI Gene: 18205
  • Gene Overview
    MyGene.info: NTF3
Location & Maps
more
  • Sequence Map
    Chr6:126101412-126166910 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65499 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NTF3, neurotrophin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NTF3, neurotrophin 3
    Orthology source: HomoloGene
  • Synonyms
    HDNF, NGF2, NGF-2, NT3, NT-3
  • Links
    NCBI Gene ID: 4908
    neXtProt AC: NX_P20783

  • Chr Location
    12p13; chr12:5432114-5495299 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Ntf3 mouse models

Human Disease Mouse Models
       Atrial Septal Defect 1; ASD1   OMIM: 108800 View 1 model
Tetralogy of Fallot; TOF   OMIM: 187500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    120 phenotypes from 12 alleles in 18 genetic backgrounds
    23 phenotypes from multigenic genotypes
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit loss of peripheral sensory and sympathetic neurons, lack of spinal propioceptive afferents and their sense organs, impaired suckling and movement, and postnatal lethality. Heterozygotes show mild defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056716 VEGA Gene Model | MGI Sequence Detail 65499 C57BL/6J ±  kb
transcript OTTMUST00000139973 VEGA | MGI Sequence Detail 1343 Not Applicable  
polypeptide OTTMUSP00000073412 VEGA | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    205 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 6
    cDNA 16
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12937, MGD-MRK-12939, MGI:1353664, MGI:2141474
References
more
  • Summaries
    All 227
    Developmental Gene Expression 69
    Diseases 1
    Gene Ontology 23
    Phenotypes 114
  • Earliest
    J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
  • Latest
    J:228865 Law C, et al., Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci. 2016 Jan 13;36(2):561-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory