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Ntf3
Gene Detail
Symbol

Name
ID
Ntf3
neurotrophin 3
MGI:97380
Synonyms
NT3, NT-3, Ntf-3
Feature Type
protein coding gene
Genetic Map
Chromosome 6
60.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:126101413-126166744 bp, - strand
From Ensembl annotation of GRCm38

  65332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1896  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NTF3
Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ntf3

Human
homologs
NTF3, neurotrophin 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4908
neXtProt AC: NX_P20783

Human Synonyms: HDNF, NGF2, NGF-2, NT3, NT-3

Human Chr (Location): 12p13; chr12:5432114-5495299 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit loss of peripheral sensory and sympathetic neurons, lack of spinal propioceptive afferents and their sense organs, impaired suckling and movement, and postnatal lethality. Heterozygotes show mild defects.
 
Human Diseases Modeled in Mice Using Ntf3 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Ntf3 interacts with 128 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (67 records)
Data Summary: Results (375)    Tissues (210)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 193
In situ reporter (knock in) 171
Northern blot 9
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ntf3    NEW 
Molecular
reagents
All nucleic(24) Genomic(6) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000049107 (Evidence)
Entrez Gene 18205 (Evidence)
UniGene 267570
DFCI TC1584089, TC1687539
DoTS DT.50316279, DT.94294599, DT.99849442
NIA Mouse Gene Index U027873
Consensus CDS Project CCDS20553.1, CCDS51914.1
International Mouse Phenotyping Consortium Status Ntf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049107 Ensembl Gene Model | MGI Sequence Detail 65332 C57BL/6J ±  kb
transcript ENSMUST00000112244 Ensembl | MGI Sequence Detail 1427 Not Applicable 
polypeptide ENSMUSP00000107863 Ensembl | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019846 Nerve growth factor conserved site
InterPro IPR020408 Nerve growth factor-like
InterPro IPR002072 Nerve growth factor-related
InterPro IPR015578 Neurotrophin-3
Protein Ontology PR:000011459 neurotrophin-3
References
(Earliest) J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
(Latest) J:218020 Wan G, et al., Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. Elife. 2014;3
All references(227)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12937, MGD-MRK-12939, MGI:1353664, MGI:2141474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory