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Ntf3 Gene Detail
Summary
  • Symbol
    Ntf3
  • Name
    neurotrophin 3
  • Synonyms
    NT-3, NT3, Ntf-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97380
    NCBI Gene: 18205
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:126078375-126143703 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 60.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1843 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97380
 protein coding gene Chr6:126078375-126143873 (-)
129S1/SvImJ ENSMUSG00200044998
 protein coding gene Chr6:123143469-123206804 (-)
A/J ENSMUSG00195031015
 protein coding gene Chr6:122578586-122644091 (-)
AKR/J ENSMUSG00220021154
 protein coding gene Chr6:121440233-121505739 (-)
BALB/cJ ENSMUSG00180031808
 protein coding gene Chr6:122915587-122981090 (-)
C3H/HeJ ENSMUSG00175030759
 protein coding gene Chr6:122579445-122644948 (-)
C57BL/6NJ ENSMUSG00215025811
 protein coding gene Chr6:122902224-122967730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028884
 protein coding gene Chr6:121802973-121865166 (-)
CAST/EiJ ENSTCUG00005039257
 protein coding gene Chr6:122759533-122823179 (-)
CBA/J ENSMUSG00210016008
 protein coding gene Chr6:122616198-122681688 (-)
DBA/2J ENSMUSG00185041295
 protein coding gene Chr6:123316263-123381762 (-)
FVB/NJ ENSMUSG00205050910
 protein coding gene Chr6:122181798-122247297 (-)
JF1/MsJ ENSUMUG00000041501
 protein coding gene Chr6:121732810-121796652 (-)
LP/J ENSMUSG00230039878
 protein coding gene Chr6:124513558-124579057 (-)
NOD/ShiLtJ ENSMUSG00190034033
 protein coding gene Chr6:122299128-122362536 (-)
NZO/HlLtJ ENSMUSG00225014666
 protein coding gene Chr6:126538838-126602158 (-)
PWK/PhJ ENSLUMG00010038868
 protein coding gene Chr6:120982638-121046563 (-)
SPRET/EiJ ENSMSPG00010034056
 protein coding gene Chr6:123837627-123901311 (-)
WSB/EiJ ENSIUOG00005043096
 protein coding gene Chr6:123015037-123078294 (-)



Homology
more
  • Human Ortholog
    NTF3, neurotrophin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTF3, neurotrophin 3
  • Synonyms
    HDNF, NGF-2, NGF2, NT-3, NT3
  • Links
    NCBI Gene ID: 4908
    UniProt: P20783

  • Chr Location
    12p13.31; chr12:5430332-5521536 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ntf3 mouse models; 2 with human NTF3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    121 phenotypes from 12 alleles in 19 genetic backgrounds
    23 phenotypes from multigenic genotypes
    130 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit loss of peripheral sensory and sympathetic neurons, lack of spinal propioceptive afferents and their sense organs, impaired suckling and movement, and postnatal lethality. Heterozygotes show mild defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1189
  • Tissues
    341
  • cDNA Data
    21
  • Literature Summary
    85
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18205 NCBI Gene Model | MGI Sequence Detail 65329 C57BL/6J ±  kb
    transcript NM_001410128 RefSeq | MGI Sequence Detail 1604 ZRU/MplStud  
    polypeptide P20181 UniProt | EBI | MGI Sequence Detail 258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 6
      cDNA 22
      Primer pair 4
      Other 7
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12937, MGD-MRK-12939, MGI:1353664, MGI:2141474
    References
    more
    • Summaries
      All 294
      Developmental Gene Expression 85
      Diseases 1
      Gene Ontology 27
      Phenotypes 130
    • Earliest
      J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
    • Latest
      J:362503 Paul MA, et al., Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells. Nat Neurosci. 2025 Feb;28(2):308-319
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory