About   Help   FAQ
Npr1
Gene Detail
 Symbol
Name
ID
Npr1
natriuretic peptide receptor 1
MGI:97371
Synonyms GC-A, guanylyl cyclase-A, NPRA, NPR-A
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:90450591-90465866 bp, - strand
From VEGA annotation of GRCm38

  15276 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37367  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Npr1

Human
homologs
Human Homolog NPR1, natriuretic peptide receptor 1
NCBI Gene ID 4881
neXtProt AC  NX_P16066
Human Synonyms  ANPa, ANPRA, GUC2A, GUCY2A, NPRA
Human Chr (Location)  1q21-q22; chr1:153678617-153693992 (+)  GRCh38
Alleles
and
phenotypes
All alleles(55) : Gene trapped(47) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene can lead to hypertension, cardiac hypertrophy, lethal vascular events, congestive heart failure in response to volume overload, reduced serum testosterone levels, altered steroidogenesis, and reduced myocardial PMN infiltration and infarct size after I/R injury.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cell surface receptor signaling pathway, cGMP biosynthetic process, ...
Component integral component of membrane, intracellular, ...
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (157)    Tissues (108)    Images (33)
Theiler Stages: 17, 20, 22, 23
Assay TypeResults
RNA in situ 155
RT-PCR 2
cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(31) Genomic(1) cDNA(28) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029513 (Evidence)
Ensembl Gene ModelENSMUSG00000027931 (Evidence)
Entrez Gene18160 (Evidence)
UniGene4627
DFCITC1590691, TC1597333
DoTSDT.488736, DT.94228543
NIA Mouse Gene IndexU024299
EC4.6.1.2
Consensus CDS ProjectCCDS17529.1
International Mouse Knockout Project StatusNpr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029513 VEGA Gene Model | MGI Sequence Detail 15276 C57BL/6J ±  kb
transcript OTTMUST00000073130 VEGA | MGI Sequence Detail 4066 Not Applicable 
polypeptide OTTMUSP00000037824 VEGA | MGI Sequence Detail 1057 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(5) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR001170 Natriuretic peptide receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000011377 atrial natriuretic peptide receptor 1
References (Earliest) J:10644 Pandey KN, et al., Molecular cloning and expression of murine guanylate cyclase/atrial natriuretic factor receptor cDNA. J Biol Chem. 1990 Jul 25;265(21):12342-8
(Latest) J:208811 Vellaichamy E, et al., Genetically altered mutant mouse models of guanylyl cyclase/natriuretic peptide receptor-A exhibit the cardiac expression of proinflammatory mediators in a gene-dose-dependent manner. Endocrinology. 2014 Mar;155(3):1045-56
All references(118)
Other
accession IDs
MGD-MRK-12925, MGD-MRK-13537, MGI:2139841

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory