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Npr1 Gene Detail
Summary
  • Symbol
    Npr1
  • Name
    natriuretic peptide receptor 1
  • Synonyms
    GC-A, guanylyl cyclase-A, NPR-A, NPRA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97371
    NCBI Gene: 18160
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90357898-90373173 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.23 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97371
 protein coding gene Chr3:90357898-90373235 (-)
129S1/SvImJ ENSMUSG00200036764
 protein coding gene Chr3:87213272-87228719 (-)
A/J ENSMUSG00195051456
 protein coding gene Chr3:87228441-87243881 (-)
AKR/J ENSMUSG00220043593
 protein coding gene Chr3:87191944-87207393 (-)
BALB/cJ ENSMUSG00180038637
 protein coding gene Chr3:87321111-87336484 (-)
C3H/HeJ ENSMUSG00175039817
 protein coding gene Chr3:87160960-87176398 (-)
C57BL/6NJ ENSMUSG00215049701
 protein coding gene Chr3:87601028-87616469 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025236
 protein coding gene Chr3:83231952-83248042 (-)
CAST/EiJ ENSTCUG00005047956
 protein coding gene Chr3:86682740-86698271 (-)
CBA/J ENSMUSG00210039179
 protein coding gene Chr3:87298637-87314078 (-)
DBA/2J ENSMUSG00185048371
 protein coding gene Chr3:87408179-87423616 (-)
FVB/NJ ENSMUSG00205039182
 protein coding gene Chr3:86222215-86237659 (-)
JF1/MsJ ENSUMUG00000047700
 protein coding gene Chr3:87024403-87039924 (-)
LP/J ENSMUSG00230031240
 protein coding gene Chr3:89434490-89449935 (-)
NOD/ShiLtJ ENSMUSG00190045220
 protein coding gene Chr3:87694056-87709472 (-)
NZO/HlLtJ ENSMUSG00225011914
 protein coding gene Chr3:92192229-92207656 (-)
PWK/PhJ ENSLUMG00010051857
 protein coding gene Chr3:87057362-87072870 (-)
SPRET/EiJ ENSMSPG00010048757
 protein coding gene Chr3:87935170-87951097 (-)
WSB/EiJ ENSIUOG00005049029
 protein coding gene Chr3:87713965-87729424 (-)



Homology
more
  • Human Ortholog
    NPR1, natriuretic peptide receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPR1, natriuretic peptide receptor 1
  • Synonyms
    ANPa, ANP-A, ANPRA, GC-A, GUC2A, GUCY2A, NPRA
  • Links
    NCBI Gene ID: 4881
    UniProt: P16066

  • Chr Location
    1q21.3; chr1:153677965-153694110 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NPR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 7 alleles in 8 genetic backgrounds
    3 images
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene can lead to hypertension, cardiac hypertrophy, lethal vascular events, congestive heart failure in response to volume overload, reduced serum testosterone levels, altered steroidogenesis, and reduced myocardial PMN infiltration and infarct size after I/R injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    117
  • cDNA Data
    29
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027931 Ensembl Gene Model | MGI Sequence Detail 15276 C57BL/6J ±  kb
    transcript ENSMUST00000029540 Ensembl | MGI Sequence Detail 4066 Not Applicable  
    polypeptide ENSMUSP00000029540 Ensembl | MGI Sequence Detail 1057 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011377 atrial natriuretic peptide receptor 1
      (term hierarchy)
    • EC
      4.6.1.2
    • InterPro Domains
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR001170 Adenylyl cyclase class-4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR050401 Cyclic nucleotide synthase
      IPR029787 Nucleotide cyclase
      IPR028082 Periplasmic binding protein-like I
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001828 Receptor, ligand binding region
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    • GlyGen
      P18293 7 sites, 4 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 29
      Primer pair 3
      Other 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12925, MGD-MRK-13537, MGI:2139841
    References
    more
    • Summaries
      All 178
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 14
      Phenotypes 106
    • Earliest
      J:10644 Pandey KN, et al., Molecular cloning and expression of murine guanylate cyclase/atrial natriuretic factor receptor cDNA. J Biol Chem. 1990 Jul 25;265(21):12342-8
    • Latest
      J:374342 Ramasamy C, et al., Podocyte cell-specific Npr1 is required for blood pressure and renal homeostasis in male and female mice: role of sex-specific differences. Physiol Genomics. 2024 Oct 1;56(10):672-690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory