Npr1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Npr1
natriuretic peptide receptor 1
MGI:97371

40 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Npr1^tm1(Npr1)Unc/\Npr1⁺ involves: 129P2/OlaHsd * C57BL/6	decreased systemic arterial blood pressure	J:46175
\Npr1^tm1(Npr1)Unc/\Npr1^tm1(Npr1)Unc involves: 129P2/OlaHsd * C57BL/6	abnormal sex gland physiology	J:58344
	decreased systemic arterial blood pressure	J:46175
	increased circulating testosterone level	J:58344
\Npr1^tm1.1Kkan/\Npr1^tm1.1Kkan \Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	cardiac hypertrophy	J:220676
	increased metastatic potential	J:220676
	increased susceptibility to induced morbidity/mortality	J:220676
	increased systemic arterial blood pressure	J:220676
\Npr1^tm1.1Rsha/\Npr1⁺ involves: C57BL/6	cardiac hypertrophy	J:201932
	increased circulating aldosterone level	J:201932
	increased heart weight	J:201932
	increased mean systemic arterial blood pressure	J:201932
	increased systemic arterial systolic blood pressure	J:201932
\Npr1^tm1.1Rsha/\Npr1^tm1.1Rsha involves: C57BL/6	cardiac hypertrophy	J:201932
	increased circulating aldosterone level	J:201932
	increased heart weight	J:201932
	increased mean systemic arterial blood pressure	J:201932
	increased systemic arterial systolic blood pressure	J:201932
\Npr1^tm1Gar/\Npr1⁺ involves: 129S7/SvEvBrd * C57BL/6J	increased systemic arterial blood pressure	J:30007
	increased systemic arterial diastolic blood pressure	J:30007
	increased systemic arterial systolic blood pressure	J:30007
	salt-resistant hypertension	J:30007
\Npr1^tm1Gar/\Npr1^tm1Gar B6.129S7-Npr1^tm1Gar	decreased myocardial infarct size	J:70496
\Npr1^tm1Gar/\Npr1^tm1Gar B6.129S7-Npr1^tm1Gar	impaired neutrophil chemotaxis	J:70496
\Npr1^tm1Gar/\Npr1^tm1Gar involves: 129S7/SvEvBrd * C57BL/6J	abnormal systemic arterial blood pressure	J:42893
	abnormal vasodilation	J:42893
	hydrops fetalis	J:30007
	increased circulating atrial natriuretic factor	J:42893
	increased systemic arterial blood pressure	J:30007
	increased systemic arterial diastolic blood pressure	J:30007
	increased systemic arterial systolic blood pressure	J:30007
	normal mortality/aging	J:30007
	salt-resistant hypertension	J:30007
\Npr1^tm1Kuhn/\Npr1^tm1Kuhn \Tg(Myh6-cre)2182Mds/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal cardiac muscle relaxation	J:83298
	abnormal myocardial fiber morphology	J:83298
	cardiac hypertrophy	J:83298
	cardiac interstitial fibrosis	J:83298
	congestive heart failure	J:83298
	decreased systemic arterial systolic blood pressure	J:83298
	hypotension	J:83298
	increased circulating atrial natriuretic factor	J:83298
\Npr1^tm1Kuhn/\Npr1^tm1Kuhn \Tg(Tagln-cre)1Her/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal systemic arterial blood pressure	J:76460
	abnormal vasodilation	J:76460
\Npr1^tm1Mae/\Npr1⁺ B6.129P2-Npr1^tm1Mae	congestive heart failure	J:101857
\Npr1^tm1Mae/\Npr1⁺ involves: 129P2/OlaHsd * C57BL/6	increased systemic arterial blood pressure	J:46175
\Npr1^tm1Mae/\Npr1^tm1Mae B6.129P2-Npr1^tm1Mae	cardiac hypertrophy	J:78579, J:101857
	congestive heart failure	J:101857
	enlarged heart	J:78579
	hypertension	J:78579
	increased circulating atrial natriuretic factor	J:78579
	normal mortality/aging	J:101857
\Npr1^tm1Mae/\Npr1^tm1Mae involves: 129P2/OlaHsd * C57BL/6	abnormal myocardium layer morphology	J:74420
	abnormal pulmonary circulation	J:74420
	abnormal sex gland physiology	J:58344
	aortic dissection	J:74420
	cardiac hypertrophy	J:74420
	cardiac interstitial fibrosis	J:74420
	congestive heart failure	J:74420
	decreased circulating renin level	J:74420
	decreased circulating testosterone level	J:58344
	dilated heart left ventricle	J:74420
	dilated heart right ventricle	J:74420
	myocardium necrosis	J:74420
	premature death	J:74420, J:101857
	pulmonary embolism	J:74420
	salt-resistant hypertension	J:74420
\Tg(Tek-Npr1)#Kkan/0 involves: C57BL/6	decreased metastatic potential	J:220676
\Tg(Tek-Npr1)#Kkan/0 involves: C57BL/6	decreased susceptibility to induced morbidity/mortality	J:220676

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