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Nppc
Gene Detail
 Symbol
Name
ID
Nppc
natriuretic peptide type C
MGI:97369
Synonyms CNP, lbab, natriuretic peptide precursor C
Feature Type protein coding gene
Genetic Map
Chromosome 1
43.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr1:86666293-86670573 bp, - strand
From NCBI annotation of GRCm38

  4281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: natriuretic peptide C precursor
Gene Tree: Nppc

Human
homologs
Human Homolog NPPC, natriuretic peptide C
NCBI Gene ID 4880
neXtProt AC  NX_P23582
Human Synonyms  CNP, CNP2
Human Chr (Location)  2q37.1; chr2:231922095-231926328 (-)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit severe dwarfism due to impaired endochondral ossification. Mutants are viable at birth, but fewer than half survive postnatal development. Mice homozygous for a knock-out allele exhibit abnormal secondary sensory axon bifurcation.
 
Phenotype Images(6)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cGMP biosynthetic process, growth plate cartilage chondrocyte differentiation, ...
Component extracellular region, extracellular space, ...
Function hormone activity, neuropeptide hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (13)    Tissues (13)    Images (8)
Theiler Stages: 17, 20, 22
Assay TypeResults
RNA in situ 13
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) Genomic(7) cDNA(5) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026241 (Evidence)
Entrez Gene18159 (Evidence)
UniGene12802
DFCITC1586598
DoTSDT.55109552
NIA Mouse Gene IndexU021562
Consensus CDS ProjectCCDS15123.1
International Mouse Knockout Project StatusNppc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18159 NCBI Gene Model | MGI Sequence Detail 4281 C57BL/6J ±  kb
transcript NM_010933 RefSeq | MGI Sequence Detail 1042 C57BL/6 
polypeptide Q61839 UniProt | EBI | MGI Sequence Detail 126 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms PCR(3) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000663 Natriuretic peptide
InterPro IPR002406 Natriuretic peptide, C type
Protein Ontology PR:000011376 C-type natriuretic peptide
Graphical View of Protein Domain Structure
References (Earliest) J:34720 Seidman CE, et al., The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science. 1984 Jul 20;225(4659):324-6
(Latest) J:205571 Ter-Avetisyan G, et al., Bifurcation of Axons from Cranial Sensory Neurons Is Disabled in the Absence of Npr2-Induced cGMP Signaling. J Neurosci. 2014 Jan 15;34(3):737-47
All references(59)
Other
accession IDs
MGD-MRK-12923, MGI:2387556

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory