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Nppc
Gene Detail
Symbol

Name
ID
Nppc
natriuretic peptide type C
MGI:97369
Synonyms
CNP, lbab, natriuretic peptide precursor C
Feature Type
protein coding gene
Genetic Map
Chromosome 1
43.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr1:86666291-86670571 bp, - strand
From VEGA annotation of GRCm38

  4281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: natriuretic peptide C precursor
Gene Tree: Nppc

Human
homologs
Human Homolog NPPC, natriuretic peptide C
NCBI Gene ID 4880
neXtProt AC  NX_P23582
Human Synonyms  CNP, CNP2
Human Chr (Location)  2q37.1; chr2:231922095-231926328 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit severe dwarfism due to impaired endochondral ossification. Mutants are viable at birth, but fewer than half survive postnatal development. Mice homozygous for a knock-out allele exhibit abnormal secondary sensory axon bifurcation.
 
Phenotype Images(6)
Interactions
Nppc interacts with 162 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (13)    Tissues (13)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(7) cDNA(5) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000048101 (Evidence)
Ensembl Gene ModelENSMUSG00000026241 (Evidence)
Entrez Gene18159 (Evidence)
UniGene12802
DFCITC1586598
DoTSDT.55109552
NIA Mouse Gene IndexU021562
Consensus CDS ProjectCCDS15123.1
International Mouse Knockout Project StatusNppc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048101 VEGA Gene Model | MGI Sequence Detail 4281 C57BL/6J ±  kb
transcript OTTMUST00000123581 VEGA | MGI Sequence Detail 1042 Not Applicable 
polypeptide OTTMUSP00000067450 VEGA | MGI Sequence Detail 126 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms
PCR(3) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000663 Natriuretic peptide
InterPro IPR002406 Natriuretic peptide, C type
Protein Ontology PR:000011376 C-type natriuretic peptide
References
(Earliest) J:34720 Seidman CE, et al., The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science. 1984 Jul 20;225(4659):324-6
(Latest) J:205571 Ter-Avetisyan G, et al., Bifurcation of Axons from Cranial Sensory Neurons Is Disabled in the Absence of Npr2-Induced cGMP Signaling. J Neurosci. 2014 Jan 15;34(3):737-47
All references(60)
Other
accession IDs
MGD-MRK-12923, MGI:2387556

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory