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Nppc
Gene Detail
Symbol

Name
ID
Nppc
natriuretic peptide type C
MGI:97369
Synonyms
CNP, lbab, natriuretic peptide precursor C
Feature Type
protein coding gene
Genetic Map
Chromosome 1
43.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr1:86666291-86670571 bp, - strand
From VEGA annotation of GRCm38

  4281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NPPC
Protein SuperFamily: natriuretic peptide C precursor
Gene Tree: Nppc

Human
homologs
NPPC, natriuretic peptide C
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4880
neXtProt AC: NX_P23582

Human Synonyms: CNP, CNP2

Human Chr (Location): 2q37.1; chr2:231922095-231926389 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit severe dwarfism due to impaired endochondral ossification. Mutants are viable at birth, but fewer than half survive postnatal development. Mice homozygous for a knock-out allele exhibit abnormal secondary sensory axon bifurcation.
 
Phenotype Images(6)
Interactions
Nppc interacts with 162 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (13)    Tissues (13)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nppc    NEW 
Molecular
reagents
All nucleic(16) Genomic(7) cDNA(5) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000048101 (Evidence)
Ensembl Gene Model ENSMUSG00000026241 (Evidence)
Entrez Gene 18159 (Evidence)
UniGene 12802
DFCI TC1586598
DoTS DT.55109552
NIA Mouse Gene Index U021562
Consensus CDS Project CCDS15123.1
International Mouse Phenotyping Consortium Status Nppc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048101 VEGA Gene Model | MGI Sequence Detail 4281 C57BL/6J ±  kb
transcript OTTMUST00000123581 VEGA | MGI Sequence Detail 1042 Not Applicable 
polypeptide OTTMUSP00000067450 VEGA | MGI Sequence Detail 126 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
PCR(3) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000663 Natriuretic peptide
InterPro IPR030480 Natriuretic peptide, conserved site
InterPro IPR002406 Natriuretic peptide, C type
Protein Ontology PR:000011376 C-type natriuretic peptide
References
(Earliest) J:34720 Seidman CE, et al., The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science. 1984 Jul 20;225(4659):324-6
(Latest) J:215744 Moyes AJ, et al., Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest. 2014 Sep 2;124(9):4039-51
All references(59)
Other
accession IDs
MGD-MRK-12923, MGI:2387556

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory