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Nkx2-3 Gene Detail
Summary
  • Symbol
    Nkx2-3
  • Name
    NK2 homeobox 3
  • Synonyms
    Nkx-2.3, Nkx2.3, tinman
  • Feature Type
    protein coding gene
  • IDs
    MGI:97348
    NCBI Gene: 18089
  • Gene Overview
    MyGene.info: NKX2-3
Location & Maps
more
  • Sequence Map
    Chr19:43612325-43615892 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3568 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 36.67 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NKX2-3, NK2 homeobox 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NKX2-3, NK2 homeobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3
  • Links
    NCBI Gene ID: 159296
    neXtProt AC: NX_Q8TAU0

  • Chr Location
    10q24.2; chr10:99532933-99536524 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    58 phenotypes from 2 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Incidental Mutations
    APF , CvDC
Homozygotes exhibit postnatal lethality due to acute intestinal malabsorption. Survivors recover well but exhibit splenic and Peyer's patch hypoplasia, intestinal villus malformation, gut truncation and distension, abnormal molar and sublingual gland development, and deranged lymphocyte homing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029846 VEGA Gene Model | MGI Sequence Detail 3568 C57BL/6J ±  kb
transcript OTTMUST00000074066 VEGA | MGI Sequence Detail 2112 Not Applicable  
polypeptide OTTMUSP00000038428 VEGA | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    14 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 5
    cDNA 11
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12890
References
more
  • Summaries
    All 45
    Developmental Gene Expression 14
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:2959 Price M, et al., Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992 Feb;8(2):241-55
  • Latest
    J:188836 Norden J, et al., Wnt/beta-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation. Circ Res. 2011 Sep 2;109(6):e42-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory