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Nkx2-3
Gene Detail
 Symbol
Name
ID
Nkx2-3
NK2 homeobox 3
MGI:97348
Synonyms Nkx-2.3, Nkx2.3, tinman
Feature Type protein coding gene
Genetic Map
Chromosome 19
36.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:43612325-43615892 bp, + strand
From VEGA annotation of GRCm38

  3568 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17061  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Nkx2-3

Human
homologs
Human Homolog NKX2-3, NK2 homeobox 3
NCBI Gene ID 159296
neXtProt AC  NX_Q8TAU0
Human Synonyms  CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3
Human Chr (Location)  10q24.2; chr10:99532933-99536524 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Homozygotes exhibit postnatal lethality due to acute intestinal malabsorption. Survivors recover well but exhibit splenic and Peyer's patch hypoplasia, intestinal villus malformation, gut truncation and distension, abnormal molar and sublingual gland development, and deranged lymphocyte homing.
 
Interactions
Nkx2-3 interacts with 78 markers (Mir15a, Mir22, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process B cell differentiation, CD4-positive, alpha-beta T cell differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (130)    Tissues (70)    Images (28)
Theiler Stages: 11, 15, 17, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 105
RT-PCR 25
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(5) cDNA(11) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000029846 (Evidence)
Ensembl Gene ModelENSMUSG00000044220 (Evidence)
Entrez Gene18089 (Evidence)
UniGene56994
DFCITC1581421
DoTSDT.87057171, DT.94279578
NIA Mouse Gene IndexU019478
Consensus CDS ProjectCCDS29833.1
International Mouse Knockout Project StatusNkx2-3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029846 VEGA Gene Model | MGI Sequence Detail 3568 C57BL/6J ±  kb
transcript OTTMUST00000074066 VEGA | MGI Sequence Detail 2112 Not Applicable 
polypeptide OTTMUSP00000038428 VEGA | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011243 homeobox protein Nkx-2.3
References (Earliest) J:2959 Price M, et al., Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992 Feb;8(2):241-55
(Latest) J:188836 Norden J, et al., Wnt/beta-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation. Circ Res. 2011 Sep 2;109(6):e42-50
All references(50)
Other
accession IDs
MGD-MRK-12890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory