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Ngfr
Gene Detail
 Symbol
Name
ID
Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
MGI:97323
Synonyms LNGFR, p75, p75 neurotrophin receptor, p75NGFR, p75NTR, Tnfrsf16
Feature Type protein coding gene
Genetic Map
Chromosome 11
59.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr11:95568818-95587735 bp, - strand
From VEGA annotation of GRCm38

  18918 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: tumor necrosis factor receptor superfamily member 16
Gene Tree: Ngfr

Human
homologs
Human Homolog NGFR, nerve growth factor receptor
NCBI Gene ID 4804
neXtProt AC  NX_P08138
Human Synonyms  CD271, Gp80-LNGFR, p75NTR, p75(NTR), TNFRSF16
Human Chr (Location)  17q21-q22; chr17:49495293-49515020 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(11) Targeted(9)
Genomic Mutations involving Ngfr (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit increased perinatal lethality, skin abnormalities, growth retardation, reduced sensory nerve innervation, elevated pain threshold, ataxia, reduced sciatic nerve diameter, and blood vessel abnormalities.
 
Interactions
Ngfr interacts with 225 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process apoptotic process, axon guidance, ...
Component cell, cell surface, ...
Function beta-amyloid binding, death receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (214 records)
Data Summary: Results (557)    Tissues (245)    Images (103)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 64
RNA in situ 399
Northern blot 6
Western blot 9
RT-PCR 79
cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(2) cDNA(40) Primer pair(6) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000001661 (Evidence)
Ensembl Gene ModelENSMUSG00000000120 (Evidence)
Entrez Gene18053 (Evidence)
UniGene283893
DFCITC1580542
DoTSDT.484334
NIA Mouse Gene IndexU033303
Consensus CDS ProjectCCDS25279.1
International Mouse Knockout Project StatusNgfr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001661 VEGA Gene Model | MGI Sequence Detail 18918 C57BL/6J ±  kb
transcript OTTMUST00000003289 VEGA | MGI Sequence Detail 3446 Not Applicable 
polypeptide OTTMUSP00000001585 VEGA | MGI Sequence Detail 427 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(5)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022325 Tumour necrosis factor receptor 16
Protein Ontology PR:000001405 tumor necrosis factor receptor superfamily member 16
References (Earliest) J:14649 Sutter A, et al., Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem. 1979 Jul 10;254(13):5972-82
(Latest) J:207835 Suo D, et al., Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci. 2014 Jan;17(1):36-45
All references(459)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12842

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory