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Myl2 Gene Detail
Summary
  • Symbol
    Myl2
  • Name
    myosin, light polypeptide 2, regulatory, cardiac, slow
  • Synonyms
    MLC-2, Mlc2v, MLC-2v, Mylpc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97272
    NCBI Gene: 17906
  • Gene Overview
    MyGene.info: MYL2
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122100904-122113398 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.16 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97272
protein coding gene Chr5:122100904-122113472 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030041
protein coding gene Chr5:125706128-125712008 (+)
A/J MGP_AJ_G0030006
protein coding gene Chr5:120515746-120528405 (+)
AKR/J MGP_AKRJ_G0029942
protein coding gene Chr5:124383472-124395993 (+)
BALB/cJ MGP_BALBcJ_G0030017
protein coding gene Chr5:121860753-121873215 (+)
C3H/HeJ MGP_C3HHeJ_G0029734
protein coding gene Chr5:124989459-125003647 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030470
protein coding gene Chr5:130527791-130542245 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027696
protein coding gene Chr5:115132942-115139200 (+)
CAST/EiJ MGP_CASTEiJ_G0029143
protein coding gene Chr5:124096255-124102732 (+)
CBA/J MGP_CBAJ_G0029704
protein coding gene Chr5:135652055-135664580 (+)
DBA/2J MGP_DBA2J_G0029854
protein coding gene Chr5:120567402-120579871 (+)
FVB/NJ MGP_FVBNJ_G0029810
protein coding gene Chr5:119546977-119560750 (+)
LP/J MGP_LPJ_G0029943
protein coding gene Chr5:126247384-126253264 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029841
protein coding gene Chr5:139434250-139446758 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030511
protein coding gene Chr5:123957828-123970353 (+)
PWK/PhJ MGP_PWKPhJ_G0028857
protein coding gene Chr5:119328736-119334635 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028694
protein coding gene Chr5:121680529-121687866 (+)
WSB/EiJ MGP_WSBEiJ_G0029218
protein coding gene Chr5:124640839-124646714 (+)



Homology
more
  • Human Ortholog
    MYL2, myosin light chain 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MYL2, myosin light chain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMH10, MLC2, MLC-2s/v
  • Links
    NCBI Gene ID: 4633
    neXtProt AC: NX_P10916
    UniProt: P10916

  • Chr Location
    12q24.11; chr12:110910819-110920600 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55462
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYL2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYL2 associations

Human Disease Mouse Models
      
IDs
View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 4 alleles in 4 genetic backgrounds
    110 phenotypes from multigenic genotypes
    9 images
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-in allele exhibit embryonic growth retardation and die between E12.5 and E14.5 with abnormal heart development characterized by a single ventricle, complete absence of the interventricular groove and septum, and a thin myocardium compact layer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17906 NCBI Gene Model | MGI Sequence Detail 12495 C57BL/6J ±  kb
    transcript NM_010861 RefSeq | MGI Sequence Detail 677 C57BL/6  
    polypeptide P51667 UniProt | EBI | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 222
      cDNA 199
      Primer pair 10
      Other 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12770
    References
    more
    • Summaries
      All 333
      Developmental Gene Expression 169
      Diseases 11
      Gene Ontology 11
      Phenotypes 134
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:264118 Papoutsi T, et al., Bmp2 and Notch cooperate to pattern the embryonic endocardium. Development. 2018 Jul 2;145(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory