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Myl1
Gene Detail
Symbol

Name
ID
Myl1
myosin, light polypeptide 1
MGI:97269
Synonyms
MLC1f, MLC3f, Mylf
Feature Type
protein coding gene
Genetic Map
Chromosome 1
33.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr1:66924295-66945404 bp, - strand
From VEGA annotation of GRCm38

  21110 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23194  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MYL1
Gene Tree: Myl1

Human
homologs
MYL1, myosin, light chain 1, alkali; skeletal, fast
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4632
neXtProt AC: NX_P05976

Human Synonyms: MLC1F, MLC3F

Human Chr (Location): 2q34; chr2:210290144-210315171 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygotes for a targeted null mutation exhibit developmental delay, fail to form mesoderm, and die by embryonic day 8.5.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Myl1 interacts with 51 markers (Mir10a, Mir105, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cardiac muscle contraction, muscle contraction
Component contractile fiber, myofibril, ...
Function calcium ion binding
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (186)    Tissues (42)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 155
Western blot 6
RT-PCR 14
RNase protection 3
Nuclease S1 8
cDNA source data(155)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myl1 ; ZFIN myl1    NEW 
Molecular
reagents
All nucleic(170) Genomic(11) cDNA(155) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026242 (Evidence)
Ensembl Gene Model ENSMUSG00000061816 (Evidence)
Entrez Gene 17901 (Evidence)
UniGene 1000
DFCI TC1572769, TC1579359, TC1593699, TC1730868
DoTS DT.101288928, DT.102543864, DT.55142690, DT.91480847, DT.94399244
NIA Mouse Gene Index U021426, U057610
Consensus CDS Project CCDS15024.1, CCDS48284.1
International Mouse Phenotyping Consortium Status Myl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026242 VEGA Gene Model | MGI Sequence Detail 21110 C57BL/6J ±  kb
transcript OTTMUST00000064902 VEGA | MGI Sequence Detail 1082 Not Applicable 
polypeptide OTTMUSP00000032275 VEGA | MGI Sequence Detail 188 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(12) UniProt(7)
Polymorphisms
RFLP(6) : SNPs within 2kb(330 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000030732 myosin light chain 1/3, skeletal muscle isoform
References
(Earliest) J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
(Latest) J:219250 Wissing ER, et al., P38alpha MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Hum Mol Genet. 2014 Oct 15;23(20):5452-63
All references(109)
Other
accession IDs
MGD-MRK-12767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory