Myl1
Gene Detail

Symbol Name ID

Myl1 myosin, light polypeptide 1 MGI:97269

Synonyms

MLC1f, MLC3f, Mylf

Feature Type

protein coding gene

Genetic Map

Chromosome 1

33.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr1:66924295-66945404 bp, - strand From VEGA annotation of GRCm38   21110 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23194  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Myl1

Human homologs

Human Homolog		MYL1, myosin, light chain 1, alkali; skeletal, fast
NCBI Gene ID		4632
neXtProt AC		NX_P05976
Human Synonyms		MLC1F, MLC3F
Human Chr (Location)		2q33-q34; chr2:211154868-211179895 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a targeted null mutation exhibit developmental delay, fail to form mesoderm, and die by embryonic day 8.5.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	cardiac muscle contraction, muscle contraction
Component	contractile fiber, myofibril, ...
Function	calcium ion binding

External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (169)    Tissues (37)    Images (45)
Theiler Stages: 11, 13, 16, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	145
Western blot	6
RT-PCR	10
Nuclease S1	8

cDNA source data(157)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(171) Genomic(11) cDNA(157) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026242 (Evidence)
Ensembl Gene Model	ENSMUSG00000061816 (Evidence)
Entrez Gene	17901 (Evidence)
UniGene	1000
DFCI	TC1572769, TC1579359, TC1593699, TC1730868
DoTS	DT.101288928, DT.102543864, DT.55142690, DT.91480847, DT.94399244
NIA Mouse Gene Index	U021426, U057610
Consensus CDS Project	CCDS15024.1, CCDS48284.1
International Mouse Knockout Project Status	Myl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026242	VEGA Gene Model | MGI Sequence Detail	21110	C57BL/6J
transcript	OTTMUST00000064902	VEGA | MGI Sequence Detail	1082	Not Applicable
polypeptide	OTTMUSP00000032275	VEGA | MGI Sequence Detail	188	Not Applicable

All sequences(59) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(6) : SNPs(190 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	Calcium-binding EF-hand
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
Protein Ontology	PR:000030732	myosin light chain 1/3, skeletal muscle isoform

References

(Earliest) J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
(Latest) J:195282 Ryu MJ, et al., Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. PLoS Genet. 2013 Mar;9(3):e1003356
All references(95)

Other accession IDs

MGD-MRK-12767