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Myl1 Gene Detail
Summary
  • Symbol
    Myl1
  • Name
    myosin, light polypeptide 1
  • Synonyms
    MLC1f, MLC3f, Mylf
  • Feature Type
    protein coding gene
  • IDs
    MGI:97269
    NCBI Gene: 17901
  • Gene Overview
    MyGene.info: MYL1
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:66963454-66984563 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 33.71 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97269
protein coding gene Chr1:66963454-66987091 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016117
protein coding gene Chr1:67195268-67216722 (-)
A/J MGP_AJ_G0016100
protein coding gene Chr1:64815445-64836244 (-)
AKR/J MGP_AKRJ_G0016057
protein coding gene Chr1:66673247-66694177 (-)
BALB/cJ MGP_BALBcJ_G0016055
protein coding gene Chr1:64894087-64916966 (-)
C3H/HeJ MGP_C3HHeJ_G0015886
protein coding gene Chr1:66916767-66940910 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016508
protein coding gene Chr1:69786132-69807600 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014229
protein coding gene Chr1:60741240-60761893 (-)
CAST/EiJ MGP_CASTEiJ_G0015470
protein coding gene Chr1:66182671-66206688 (-)
CBA/J MGP_CBAJ_G0015859
protein coding gene Chr1:72055444-72081749 (-)
DBA/2J MGP_DBA2J_G0015960
protein coding gene Chr1:64208432-64234235 (-)
FVB/NJ MGP_FVBNJ_G0015963
protein coding gene Chr1:63459099-63483946 (-)
LP/J MGP_LPJ_G0016032
protein coding gene Chr1:68151148-68174239 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015983
protein coding gene Chr1:75020771-75046090 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016555
protein coding gene Chr1:66624450-66650377 (-)
PWK/PhJ MGP_PWKPhJ_G0015257
protein coding gene Chr1:63605429-63627081 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015036
protein coding gene Chr1:66089644-66112046 (-)
WSB/EiJ MGP_WSBEiJ_G0015532
protein coding gene Chr1:66349485-66373045 (-)



Homology
more
  • Human Ortholog
    MYL1, myosin light chain 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYL1, myosin light chain 1
  • Synonyms
    MLC1F, MLC3F, MYOFTA
  • Links
    NCBI Gene ID: 4632
    neXtProt AC: NX_P05976
    UniProt: P05976

  • Chr Location
    2q34; chr2:210290144-210315171 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    65 phenotypes from multigenic genotypes
    2 images
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit developmental delay, fail to form mesoderm, and die by embryonic day 8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061816 Ensembl Gene Model | MGI Sequence Detail 21110 C57BL/6J ±  kb
    transcript ENSMUST00000027151 Ensembl | MGI Sequence Detail 1082 Not Applicable  
    polypeptide ENSMUSP00000027151 Ensembl | MGI Sequence Detail 188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 183
      Genomic 12
      cDNA 163
      Primer pair 6
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12767
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 4
      Phenotypes 92
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:309759 Chatel B, et al., Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model. Dis Model Mech. 2021 Sep 1;14(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/16/2021
    MGI 6.17
    The Jackson Laboratory