Myb
Gene Detail

Symbol Name ID

Myb myeloblastosis oncogene MGI:97249

Synonyms

c-myb

Feature Type

protein coding gene

Genetic Map

Chromosome 10

9.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(70)

Sequence Map

Chr10:21124930-21160984 bp, - strand From NCBI annotation of GRCm38   36055 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31311  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Myb transforming protein
Gene Tree: Myb

Human homologs

Human Homolog		MYB, v-myb myeloblastosis viral oncogene homolog (avian)
NCBI Gene ID		4602
neXtProt AC		NX_P10242
Human Synonyms		c-myb, Cmyb, c-myb_CDS, efg
Human Chr (Location)		6q22-q23; chr6:135502453-135540311 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(17) : Targeted(10) Gene trapped(3) Chemically induced(4)
 

Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected.

 
Human Diseases Modeled Using Mouse Myb (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	B cell differentiation, calcium ion transport, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)
Data Summary: Results (532)    Tissues (259)    Images (64)
Theiler Stages: 2, 3, 4, 5, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	431
Western blot	4
RT-PCR	97

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(16) cDNA(28) Primer pair(8) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000019982 (Evidence)
Entrez Gene	17863 (Evidence)
DFCI	TC1578598, TC1591992, TC1594933, TC1596978, TC1628109
DoTS	DT.101367861, DT.101735295, DT.491975, DT.91310703, DT.91356002, DT.94134242, DT.94205235, DT.94342982, DT.99847461
NIA Mouse Gene Index	U031594
PDB	1GUU, 1GVD, 1IDY, 1IDZ, 1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK, 1MSE, 1MSF, 2AGH, 1GV2, 1GV5, 1H88, 1H89, 1SB0
Consensus CDS Project	CCDS35861.1
International Mouse Knockout Project Status	Myb

Sequences

Length	Strain/Species
genomic	17863	NCBI Gene Model | MGI Sequence Detail	36055	C57BL/6J
transcript	NM_001198914	RefSeq | MGI Sequence Detail	3777	C57BL/6
polypeptide	P06876	UniProt | EBI | MGI Sequence Detail	636	Not Applicable

All sequences(57) RefSeq(5) UniProt(9)

Polymorphisms

RFLP(22) : SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015395	C-myb, C-terminal
InterPro	IPR003036	Core shell protein Gag P30
InterPro	IPR009057	Homeodomain-like
InterPro	IPR017930	Myb domain
InterPro	IPR017877	Myb-like domain
InterPro	IPR008919	Retrovirus capsid, N-terminal core
InterPro	IPR001005	SANT/Myb domain
InterPro	IPR012642	Transcription regulator Wos2-domain
Protein Ontology	PR:000010799	myb proto-oncogene protein

Graphical View of Protein Domain Structure

References

(Earliest) J:6672 Bergmann DG, et al., Vertebrate DNAs contain nucleotide sequences related to the transforming gene of avian myeloblastosis virus. J Virol. 1981 Nov;40(2):450-5
(Latest) J:192709 Ishida M, et al., Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells. Circ Res. 2012 Jan 20;110(2):253-64
All references(215)

Other accession IDs

MGD-MRK-12735, MGI:2143640, MGI:2143955