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Myb
Gene Detail
Symbol

Name
ID
Myb
myeloblastosis oncogene
MGI:97249
Synonyms
c-myb
Feature Type
protein coding gene
Genetic Map
Chromosome 10
9.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(67)
Sequence Map
Chr10:21124936-21160905 bp, - strand
From VEGA annotation of GRCm38

  35970 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31311  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Myb transforming protein
Gene Tree: Myb

Human
homologs
Human Homolog MYB, v-myb avian myeloblastosis viral oncogene homolog
NCBI Gene ID 4602
neXtProt AC  NX_P10242
Human Synonyms  c-myb, Cmyb, c-myb_CDS, efg
Human Chr (Location)  6q22-q23; chr6:135181315-135219173 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(4) Gene trapped(3) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected.
 
Human Diseases Modeled Using Mouse Myb (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Myb interacts with 314 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process B cell differentiation, calcium ion transport, ...
Component cytosol, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (524)    Tissues (264)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 431
Western blot 4
RT-PCR 89
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(16) cDNA(28) Primer pair(8) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000046559 (Evidence)
Ensembl Gene ModelENSMUSG00000019982 (Evidence)
Entrez Gene17863 (Evidence)
DFCITC1578598, TC1591992, TC1594933, TC1596978, TC1628109
DoTSDT.101735295, DT.491975, DT.91310703, DT.91356002, DT.94134242, DT.94205235, DT.94342982, DT.99847461
NIA Mouse Gene IndexU031594
PDB1GUU, 1GVD, 1IDY, 1IDZ, 1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK, 1MSE, 1MSF, 2AGH, 1GV2, 1GV5, 1H88, 1H89, 1SB0
Consensus CDS ProjectCCDS35861.1
International Mouse Knockout Project StatusMyb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046559 VEGA Gene Model | MGI Sequence Detail 35970 C57BL/6J ±  kb
transcript OTTMUST00000121090 VEGA | MGI Sequence Detail 3692 Not Applicable 
polypeptide OTTMUSP00000066845 VEGA | MGI Sequence Detail 755 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(5) UniProt(7)
Polymorphisms
RFLP(22) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015395 C-myb, C-terminal
InterPro IPR009057 Homeodomain-like
InterPro IPR017930 Myb domain
InterPro IPR017877 Myb-like domain
InterPro IPR001005 SANT/Myb domain
InterPro IPR012642 Transcription regulator Wos2-domain
Protein Ontology PR:000010799 myb proto-oncogene protein
References
(Earliest) J:6672 Bergmann DG, et al., Vertebrate DNAs contain nucleotide sequences related to the transforming gene of avian myeloblastosis virus. J Virol. 1981 Nov;40(2):450-5
(Latest) J:192709 Ishida M, et al., Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells. Circ Res. 2012 Jan 20;110(2):253-64
All references(219)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12735, MGI:2143640, MGI:2143955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory