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Muc1
Gene Detail
 Symbol
Name
ID
Muc1
mucin 1, transmembrane
MGI:97231
STS D3Mit49
Synonyms CD227, EMA, Muc-1
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:89229057-89233381 bp, + strand
From VEGA annotation of GRCm38

  4325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Muc1

Human
homologs
Human Homolog MUC1, mucin 1, cell surface associated
NCBI Gene ID 4582
neXtProt AC  NX_P15941
Human Synonyms  ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM
Human Chr (Location)  1q21; chr1:155185824-155192915 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MUC1
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Mice homozygous for a knock-out allele display delayed mammary tumor progression, impaired intestinal absorption of cholesterol, decreased gastric mucus accumulation, reduced secretion and accumulation of gallbladder mucin, and decreased susceptibility to cholesterol gallstone formation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ...
Component apical plasma membrane, cell surface, ...
Function p53 binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (204)    Tissues (57)    Images (41)
Theiler Stages: 16, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 20
RNA in situ 123
Northern blot 18
RT-PCR 43
cDNA source data(47)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(64) Genomic(14) cDNA(47) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020275 (Evidence)
Ensembl Gene ModelENSMUSG00000042784 (Evidence)
Entrez Gene17829 (Evidence)
UniGene16193
DFCITC1581895
DoTSDT.532785
NIA Mouse Gene IndexU003460
Consensus CDS ProjectCCDS17496.1
International Mouse Knockout Project StatusMuc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020275 VEGA Gene Model | MGI Sequence Detail 4325 C57BL/6J ±  kb
transcript OTTMUST00000048120 VEGA | MGI Sequence Detail 2242 Not Applicable 
polypeptide OTTMUSP00000021969 VEGA | MGI Sequence Detail 631 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023217 Mucin-1
InterPro IPR000082 SEA domain
Protein Ontology PR:000001890 mucin-1
References (Earliest) J:1889 Vos HL, et al., The mouse episialin (Muc1) gene and its promoter: rapid evolution of the repetitive domain in the protein. Biochem Biophys Res Commun. 1991 Nov 27;181(1):121-30
(Latest) J:199239 Magnuson MA, et al., Pancreas-specific cre driver lines and considerations for their prudent use. Cell Metab. 2013 Jul 2;18(1):9-20
All references(123)
Other
accession IDs
MGD-MRK-12703, MGD-MRK-12704

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory