About   Help   FAQ
Muc1
Gene Detail
Symbol

Name
ID
Muc1
mucin 1, transmembrane
MGI:97231
STS
Synonyms
CD227, EMA, Muc-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:89229057-89233381 bp, + strand
From VEGA annotation of GRCm38

  4325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137248  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: MUC1
Gene Tree: Muc1

Human
homologs
MUC1, mucin 1, cell surface associated
Orthology source: HGNC

IDs:
NCBI Gene ID: 4582
neXtProt AC: NX_P15941

Human Synonyms: ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM

Human Chr (Location): 1q21; chr1:155185824-155192915 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MUC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display delayed mammary tumor progression, impaired intestinal absorption of cholesterol, decreased gastric mucus accumulation, reduced secretion and accumulation of gallbladder mucin, and decreased susceptibility to cholesterol gallstone formation.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Muc1 interacts with 61 markers (Mir15a, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Component apical plasma membrane, cell surface, ...
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (232)    Tissues (62)    Images (68)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 48
RNA in situ 123
Northern blot 18
RT-PCR 43
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) Genomic(14) cDNA(47) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020275 (Evidence)
Ensembl Gene Model ENSMUSG00000042784 (Evidence)
Entrez Gene 17829 (Evidence)
UniGene 16193
DFCI TC1581895
DoTS DT.532785
NIA Mouse Gene Index U003460
Consensus CDS Project CCDS17496.1
International Mouse Phenotyping Consortium Status Muc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020275 VEGA Gene Model | MGI Sequence Detail 4325 C57BL/6J ±  kb
transcript OTTMUST00000048120 VEGA | MGI Sequence Detail 2242 Not Applicable 
polypeptide OTTMUSP00000021969 VEGA | MGI Sequence Detail 631 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000082 SEA domain
Protein Ontology PR:000001890 mucin-1
References
(Earliest) J:1889 Vos HL, et al., The mouse episialin (Muc1) gene and its promoter: rapid evolution of the repetitive domain in the protein. Biochem Biophys Res Commun. 1991 Nov 27;181(1):121-30
(Latest) J:220324 De Vas MG, et al., Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015 Mar 1;142(5):871-82
All references(128)
Other
accession IDs
MGD-MRK-12703, MGD-MRK-12704

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory