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Muc1
Gene Detail
Symbol

Name
ID
Muc1
mucin 1, transmembrane
MGI:97231
STS
Synonyms
CD227, EMA, Muc-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:89229057-89233381 bp, + strand
From VEGA annotation of GRCm38

  4325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137248  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Muc1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display delayed mammary tumor progression, impaired intestinal absorption of cholesterol, decreased gastric mucus accumulation, reduced secretion and accumulation of gallbladder mucin, and decreased susceptibility to cholesterol gallstone formation.
 
Interactions
Muc1 interacts with 61 markers (Mir15a, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Component apical plasma membrane, cell surface, ...
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (204)    Tissues (57)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 20
RNA in situ 123
Northern blot 18
RT-PCR 43
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) Genomic(14) cDNA(47) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020275 (Evidence)
Ensembl Gene ModelENSMUSG00000042784 (Evidence)
Entrez Gene17829 (Evidence)
UniGene16193
DFCITC1581895
DoTSDT.532785
NIA Mouse Gene IndexU003460
Consensus CDS ProjectCCDS17496.1
International Mouse Knockout Project StatusMuc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020275 VEGA Gene Model | MGI Sequence Detail 4325 C57BL/6J ±  kb
transcript OTTMUST00000048120 VEGA | MGI Sequence Detail 2242 Not Applicable 
polypeptide OTTMUSP00000021969 VEGA | MGI Sequence Detail 631 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000082 SEA domain
Protein Ontology PR:000001890 mucin-1
References
(Earliest) J:1889 Vos HL, et al., The mouse episialin (Muc1) gene and its promoter: rapid evolution of the repetitive domain in the protein. Biochem Biophys Res Commun. 1991 Nov 27;181(1):121-30
(Latest) J:208336 Kesavan G, et al., Cdc42/N-WASP signaling links actin dynamics to pancreatic beta cell delamination and differentiation. Development. 2014 Feb;141(3):685-96
All references(124)
Other
accession IDs
MGD-MRK-12703, MGD-MRK-12704

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory