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Mt2 Gene Detail
Summary
  • Symbol
    Mt2
  • Name
    metallothionein 2
  • Synonyms
    Mt-2, MT-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:97172
    NCBI Gene: 17750
  • Gene Overview
    MyGene.info: MT2A
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94172664-94173568 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.32 cM
  • Mapping Data
    13 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97172
protein coding gene Chr8:94172618-94173568 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033956
protein coding gene Chr8:95574416-95575365 (+)
A/J MGP_AJ_G0033939
protein coding gene Chr8:91854956-91855905 (+)
AKR/J MGP_AKRJ_G0033865
protein coding gene Chr8:94375029-94375978 (+)
BALB/cJ MGP_BALBcJ_G0033931
protein coding gene Chr8:91945113-91946062 (+)
C3H/HeJ MGP_C3HHeJ_G0033641
protein coding gene Chr8:95076774-95077723 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034452
protein coding gene Chr8:99069642-99070591 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031393
protein coding gene Chr8:85662010-85662957 (+)
CAST/EiJ MGP_CASTEiJ_G0032973
protein coding gene Chr8:94668233-94669182 (+)
CBA/J MGP_CBAJ_G0033617
protein coding gene Chr8:102359221-102360170 (+)
DBA/2J MGP_DBA2J_G0033771
protein coding gene Chr8:91324898-91325847 (+)
FVB/NJ MGP_FVBNJ_G0033718
protein coding gene Chr8:90290897-90291846 (+)
LP/J MGP_LPJ_G0033863
protein coding gene Chr8:95725833-95726782 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033760
protein coding gene Chr8:104659150-104660099 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034470
protein coding gene Chr8:94531982-94532931 (+)
PWK/PhJ MGP_PWKPhJ_G0032675
protein coding gene Chr8:90688202-90689138 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032512
protein coding gene Chr8:93357658-93358607 (+)
WSB/EiJ MGP_WSBEiJ_G0033085
protein coding gene Chr8:95050402-95051351 (+)



Homology
more
  • Human Ortholog
    MT2A, metallothionein 2A
  • Human Ortholog
    MT2A, metallothionein 2A
    Orthology source: HGNC
  • Synonyms
    MT2, MT-2, MT-II
  • Links
    NCBI Gene ID: 4502
    neXtProt AC: NX_P02795
    UniProt: P02795

  • Chr Location
    16q13; chr16:56608566-56609497 (+)  GRCh38.p7

  • HCOP
    human homology predictions: MT2A
  • Gene Tree
    Mt2
Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    104 phenotypes from multigenic genotypes
    137 phenotype references
Mice homozygous for null alleles of Mt1 and Mt2 exhibit increased sensitivity to xenobiotics and injury with decreased wound healing and abnormal mineral aborption.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031762 Ensembl Gene Model | MGI Sequence Detail 905 C57BL/6J ±  kb
transcript ENSMUST00000212806 Ensembl | MGI Sequence Detail 388 Not Applicable  
polypeptide ENSMUSP00000148308 Ensembl | MGI Sequence Detail 76 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR003019 Metallothionein
    IPR017854 Metallothionein domain superfamily
    IPR023587 Metallothionein domain superfamily, vertebrate
    IPR000006 Metallothionein, vertebrate
    IPR018064 Metallothionein, vertebrate, metal binding site
Molecular
Reagents
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  • All nucleic 177
    Genomic 5
    cDNA 166
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12574, MGD-MRK-12577, MGI:2142416
References
more
  • Summaries
    All 204
    Developmental Gene Expression 17
    Diseases 2
    Gene Ontology 4
    Phenotypes 137
  • Earliest
    J:7659 Searle PF, et al., Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol. 1984 Jul;4(7):1221-30
  • Latest
    J:282750 Bensellam M, et al., Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans. Diabetologia. 2019 Dec;62(12):2273-2286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory