88 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Atp7aMo-brJ/Atp7a+ Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri involves: 129S7/SvEvBrd * C3H/HeJ	decreased body size	J:33276
	embryonic lethality, complete penetrance	J:33276
	normal homeostasis/metabolism phenotype	J:33276
	increased sensitivity to induced cell death	J:33276
Atp7aMo-brJ/Atp7a+ Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri Tg(Mt1)174Bri/0 involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL	no abnormal phenotype detected	J:33276
Atp7aMo-brJ/Y Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J	embryonic lethality during organogenesis, incomplete penetrance	J:33276
	increased sensitivity to induced cell death	J:33276
	postnatal lethality, complete penetrance	J:33276
Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri	abnormal circulating enzyme level	J:16487
	abnormal liver morphology	J:16487
	hepatic necrosis	J:16487
	increased circulating alkaline phosphatase level	J:16487
	liver degeneration	J:16487
	premature death	J:16487
Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J	abnormal astrocyte morphology	J:89429
	abnormal compact bone morphology	J:126420
	abnormal humoral immune response	J:110643
	abnormal learning/memory/conditioning	J:112813
	abnormal long bone epiphyseal ossification zone morphology	J:126420
	abnormal long bone epiphyseal plate morphology	J:126420
	abnormal lymphocyte physiology	J:110643
	abnormal microglial cell morphology	J:89429
	abnormal physiological response to xenobiotic	J:56770, J:126620
	abnormal reproductive system physiology	J:103039
	abnormal trabecular bone morphology	J:126420
	abnormal zinc homeostasis	J:89429
	clonic seizures	J:89429
	decreased B cell number	J:110643
	decreased bone mass	J:126420
	decreased bone mineral content	J:126420
	decreased compact bone thickness	J:126420
	decreased hepatocyte proliferation	J:109814
	decreased T cell number	J:110643
	dilated kidney collecting duct	J:126620
	dilated proximal convoluted tubule	J:126620
	enlarged kidney	J:126620
	enlarged liver	J:126620
	enlarged spleen	J:110643
	normal homeostasis/metabolism phenotype	J:59769
	impaired liver regeneration	J:109814
	increased blood urea nitrogen level	J:126620
	increased CD4-positive, alpha-beta T cell number	J:110643
	increased CD8-positive, alpha-beta T cell number	J:110643
	increased IgG level	J:110643
	increased IgM level	J:110643
	increased incidence of tumors by chemical induction	J:56770
	increased lymphocyte cell number	J:110643
	increased neuron apoptosis	J:89429
	increased neutrophil cell number	J:120196
	increased physiological sensitivity to xenobiotic	J:89429, J:126420, J:126620
	increased plasma cell number	J:110643
	increased renal tubule apoptosis	J:126620
	increased spleen weight	J:110643
	increased susceptibility to injury	J:62369
	increased susceptibility to pharmacologically induced seizures	J:89429
	increased susceptibility to xenobiotic induced morbidity/mortality	J:120196
	increased thymocyte apoptosis	J:57169
	increased urine glucose level	J:126620
	kidney atrophy	J:126620
	kidney degeneration	J:126620
	kidney inflammation	J:126620
	lung inflammation	J:120196
	nephrocalcinosis	J:126620
	renal interstitial fibrosis	J:126620
	renal necrosis	J:126620
	spleen hyperplasia	J:110643
	tonic-clonic seizures	J:89429
	weight loss	J:126420
Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri involves: 129S7/SvEvBrd	abnormal hepatocyte morphology	J:120459
	abnormal lipid homeostasis	J:120459
	abnormal liver zinc level	J:34407
	abnormal microglial cell morphology	J:53929, J:103102
	abnormal microglial cell physiology	J:53929
	abnormal pancreas morphology	J:34407
	abnormal renal glomerulus morphology	J:34407
	abnormal zinc homeostasis	J:34407
	astrocytosis	J:53929, J:103102
	hemorrhage	J:53929
	hepatic necrosis	J:120459
	normal homeostasis/metabolism phenotype	J:33276
	impaired wound healing	J:53929
	increased brain apoptosis	J:53929
	increased circulating alanine transaminase level	J:120459
	increased glomerular capsule space	J:34407
	increased interleukin-1 beta secretion	J:103102
	increased interleukin-6 secretion	J:103102
	increased macrophage cell number	J:53929
	increased neuron apoptosis	J:103102
	increased physiological sensitivity to xenobiotic	J:120459
	increased sensitivity to induced cell death	J:33276
	increased susceptibility to experimental autoimmune encephalomyelitis	J:103102
	increased susceptibility to xenobiotic induced morbidity/mortality	J:120459
	increased tumor necrosis factor secretion	J:103102
	oxidative stress	J:103102
Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri involves: 129S7/SvEvBrd * C57BL/6	abnormal intestinal mineral absorption	J:47419
Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri involves: 129S7/SvEvBrd * C57BL/6J	abnormal retina ganglion layer morphology	J:116275
	increased physiological sensitivity to xenobiotic	J:116275
Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri involves: 129S7/SvEvBrd * CD-1	abnormal zinc homeostasis	J:103039
Mt1tm1Rch/Mt1tm1Rch Mt2tm1Rch/Mt2tm1Rch involves: 129P2/OlaHsd * C57BL/6J	abnormal hepatocyte morphology	J:120459
	abnormal ion homeostasis	J:14416
	abnormal lipid homeostasis	J:120459
	hepatic necrosis	J:120459
	increased circulating alanine transaminase level	J:120459
	increased incidence of tumors by chemical induction	J:120459
	increased physiological sensitivity to xenobiotic	J:120459
	increased susceptibility to xenobiotic induced morbidity/mortality	J:120459
	increased tumor incidence	J:84369