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Mpg Gene Detail
Summary
  • Symbol
    Mpg
  • Name
    N-methylpurine-DNA glycosylase
  • Synonyms
    3-methyladenine DNA glycosylase, Aag, alkylpurine-DNA-N-glycosylase, APNG, Mid1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97073
    NCBI Gene: 268395
  • Gene Overview
    MyGene.info: MPG
Location & Maps
more
  • Sequence Map
    Chr11:32226505-32232700 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6196 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 18.83 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    MPG, N-methylpurine DNA glycosylase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MPG, N-methylpurine DNA glycosylase
    Orthology source: HomoloGene
  • Synonyms
    AAG, ADPG, anpg, APNG, CRA36.1, MDG, Mid1, PIG11, PIG16
  • Links
    NCBI Gene ID: 4350
    neXtProt AC: NX_P29372

  • Chr Location
    16p13.3; chr16:77019-85851 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 5 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    5
  • Genomic Mutations
    1 involving Mpg
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit impaired base excision repair of alkylation-induced DNA damage, and increased sensitivity to methyl methanesulfonate and streptozoticin-induced diabetes. Mutants are fertile and long-lived.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005371 VEGA Gene Model | MGI Sequence Detail 6196 C57BL/6J ±  kb
transcript OTTMUST00000011983 VEGA | MGI Sequence Detail 1737 Not Applicable  
polypeptide OTTMUSP00000005545 VEGA | MGI Sequence Detail 333 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    77 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010534 DNA-3-methyladenine glycosylase
  • EC
  • InterPro Domains
    IPR011034 Formyl transferase, C-terminal-like
    IPR003180 Methylpurine-DNA glycosylase (MPG)
Molecular
Reagents
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  • All nucleic 26
    Genomic 8
    cDNA 14
    Primer pair 2
    Other 2

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-12404, MGD-MRK-19564, MGI:2144133
References
more
  • Summaries
    All 67
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 32
  • Earliest
    J:3932 Engelward BP, et al., Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11. Carcinogenesis. 1993 Feb;14(2):175-81
  • Latest
    J:225881 Fahrer J, et al., DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. Carcinogenesis. 2015 Oct;36(10):1235-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory