Mpg Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mpg
N-methylpurine-DNA glycosylase
MGI:97073

15 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mpg^{tm1a(EUCOMM)Wtsi}/Mpg^{tm1a(EUCOMM)Wtsi} C57BL/6N-Mpg^{tm1a(EUCOMM)Wtsi}/Wtsi	increased circulating alkaline phosphatase level	J:211773
Mpg^tm1Lds/Mpg^tm1Lds involves: 129P2/OlaHsd	normal immune system phenotype	J:47993
Mpg^tm1Lds/Mpg^tm1Lds involves: 129P2/OlaHsd * C57BL/6	autoimmune response	J:118148
	decreased susceptibility to autoimmune diabetes	J:118148
	increased apoptosis	J:118148
	increased circulating glucose level	J:118148
	small pancreatic islets	J:118148
Mpg^tm1Rhe/Mpg^tm1Rhe B6.129P2-Mpg^tm1Rhe	decreased incidence of tumors by chemical induction	J:86644
Mpg^tm1Rhe/Mpg^tm1Rhe B6.129P2-Mpg^tm1Rhe	increased physiological sensitivity to xenobiotic	J:86644
Mpg^tm1Rhe/Mpg^tm1Rhe involves: 129P2/OlaHsd * C57BL/6J	abnormal fat pad morphology	J:70603
	abnormal pancreatic beta cell physiology	J:70603
	abnormal pancreatic islet cell apoptosis	J:70603
	abnormal physiological response to xenobiotic	J:70603
	enhanced lipolysis	J:70603
	increased CD4-positive, alpha-beta T cell number	J:70603
	increased circulating glucose level	J:70603
	increased physiological sensitivity to xenobiotic	J:50033

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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