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Gbp4 Gene Detail
Summary
  • Symbol
    Gbp4
  • Name
    guanylate binding protein 4
  • Synonyms
    Mag-2, Mpa2, Mpa-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97072
    NCBI Gene: 17472
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:105115767-105139586 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97072
protein coding gene Chr5:105115767-105139586 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0029787
protein coding gene Chr5:102767225-102792478 (-)
AKR/J MGP_AKRJ_G0029733
protein coding gene Chr5:106211603-106248219 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0029519
protein coding gene Chr5:106514678-106632318 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030251
protein coding gene Chr5:111319079-111344997 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0029490
protein coding gene Chr5:115153478-115177777 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0029593
protein coding gene Chr5:101989602-102064129 (-)
LP/J MGP_LPJ_G0029724
protein coding gene Chr5:107816786-107873352 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0028484
protein coding gene Chr5:103280608-103304512 (-)
WSB/EiJ MGP_WSBEiJ_G0029007
protein coding gene Chr5:106050489-106062355 (-)



Homology
more
  • Human Ortholog
    GBP6, guanylate binding protein family member 6
  • Vertebrate Orthologs
    22
  • Human Ortholog
    GBP6, guanylate binding protein family member 6
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 163351
    neXtProt AC: NX_Q6ZN66
    UniProt: Q6ZN66

  • Chr Location
    1p22.2; chr1:89363877-89388160 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17472 NCBI Gene Model | MGI Sequence Detail 23820 C57BL/6J ±  kb
    transcript NM_001359079 RefSeq | MGI Sequence Detail 4637 C57BL/6  
    polypeptide NP_001346008 RefSeq | MGI Sequence Detail 644 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
      IPR003191 Guanylate-binding protein/Atlastin, C-terminal
      IPR037684 Guanylate-binding protein, C-terminal
      IPR036543 Guanylate-binding protein, C-terminal domain superfamily
      IPR015894 Guanylate-binding protein, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 63

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12401, MGD-MRK-12403, MGI:2141182
    References
    more
    • Summaries
      All 31
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/13/2020
    MGI 6.16
    The Jackson Laboratory