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Mif
Gene Detail
Symbol

Name
ID
Mif
macrophage migration inhibitory factor
MGI:96982
Synonyms
Glif
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.59 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr10:75859353-75860250 bp, - strand
From NCBI annotation of GRCm38

  898 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55655  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MIF
Gene Tree: Mif

Human
homologs
MIF, macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4282
neXtProt AC: NX_P14174

Human Synonyms: GIF, GLIF, MMIF

Human Chr (Location): 22q11.23; chr22:23894378-23895222 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MIF

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(2) Targeted(8) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for 3 distinct targeted alleles show varying immune system defects. Among these are increased endotoxin resistance and Pseudomonas clearance; reduced size of induced fibrosarcomas and lower mitotic index; and decreased contact hypersensitivity.
 
Phenotype Images(2)
Interactions
Mif interacts with 6 markers (Mir325, Mir340, Mir497, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process brain renin-angiotensin system, carboxylic acid metabolic process, ...
Component cell surface, cytoplasm, ...
Function chemoattractant activity, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (335)    Tissues (294)    Images (79)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 33
RNA in situ 302
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mif ; ZFIN mif    NEW 
Molecular
reagents
All nucleic(34) Genomic(11) cDNA(20) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000033307 (Evidence)
Entrez Gene 17319 (Evidence)
DFCI TC1571982, TC1611037
DoTS DT.101142426, DT.55107559, DT.99869455
EC 5.3.2.1, 5.3.3.12
PDB 1MFF, 1MFI, 2GDG
Consensus CDS Project CCDS23934.1
International Mouse Phenotyping Consortium Status Mif
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17319 NCBI Gene Model | MGI Sequence Detail 898 C57BL/6J ±  kb
transcript NM_010798 RefSeq | MGI Sequence Detail 554 C57BL/6 
polypeptide P34884 UniProt | EBI | MGI Sequence Detail 115 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001398 Macrophage migration inhibitory factor
InterPro IPR019829 Macrophage migration inhibitory factor, conserved site
InterPro IPR014347 Tautomerase/MIF superfamily
Protein Ontology PR:000010413 macrophage migration inhibitory factor
Graphical View of Protein Domain Structure
References
(Earliest) J:27223 Lanahan A, et al., Growth factor-induced delayed early response genes. Mol Cell Biol. 1992 Sep;12(9):3919-29
(Latest) J:222949 Chen L, et al., Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest. 2015 Jun;125(6):2399-412
All references(172)
Other
accession IDs
MGD-MRK-12232, MGD-MRK-16214, MGI:99446

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory