Mif
Gene Detail

Symbol Name ID

Mif macrophage migration inhibitory factor MGI:96982

Synonyms

Glif

Feature Type

protein coding gene

Genetic Map

Chromosome 10

38.59 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr10:75859353-75860250 bp, - strand From NCBI annotation of GRCm38   898 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55655  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Mif

Human homologs

Human Homolog		MIF, macrophage migration inhibitory factor (glycosylation-inhibiting factor)
NCBI Gene ID		4282
neXtProt AC		NX_P14174
Human Synonyms		GIF, GLIF, MMIF
Human Chr (Location)		22q11.23; chr22:24236565-24237409 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MIF

Alleles and phenotypes

All alleles(8) : Targeted(6) Gene trapped(2)
 

Homozygotes for 3 distinct targeted alleles show varying immune system defects. Among these are increased endotoxin resistance and Pseudomonas clearance; reduced size of induced fibrosarcomas and lower mitotic index; and decreased contact hypersensitivity.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (70 annotations)

Process	brain renin-angiotensin system, carboxylic acid metabolic process, ...
Component	cell surface, cytoplasm, ...
Function	cell surface binding, chemoattractant activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (126)    Tissues (126)    Images (31)
Theiler Stages: 19, 20, 22, 23, 28

Assay Type	Results
RNA in situ	126

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(11) cDNA(19) Primer pair(2)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000033307 (Evidence)
Entrez Gene	17319 (Evidence)
DFCI	TC1571982, TC1611037
DoTS	DT.101142426, DT.55107559, DT.99869455
EC	5.3.2.1, 5.3.3.12
PDB	1MFF, 1MFI, 2GDG
Consensus CDS Project	CCDS23934.1
International Mouse Knockout Project Status	Mif

Sequences

Length	Strain/Species
genomic	17319	NCBI Gene Model | MGI Sequence Detail	898	C57BL/6J
transcript	NM_010798	RefSeq | MGI Sequence Detail	554	C57BL/6
polypeptide	P34884	UniProt | EBI | MGI Sequence Detail	115	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(6) : SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001398	Macrophage migration inhibitory factor
InterPro	IPR019829	Macrophage migration inhibitory factor, conserved site
InterPro	IPR014347	Tautomerase/MIF superfamily
Protein Ontology	PR:000010413	macrophage migration inhibitory factor

Graphical View of Protein Domain Structure

References

(Earliest) J:27223 Lanahan A, et al., Growth factor-induced delayed early response genes. Mol Cell Biol. 1992 Sep;12(9):3919-29
(Latest) J:193147 Koga K, et al., Macrophage migration inhibitory factor antagonizes pressure overload-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H282-93
All references(152)

Other accession IDs

MGD-MRK-12232, MGD-MRK-16214, MGI:99446