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Mgmt
Gene Detail
Symbol

Name
ID
Mgmt
O-6-methylguanine-DNA methyltransferase
MGI:96977
Synonyms
Agat, AGT
Feature Type
protein coding gene
Genetic Map
Chromosome 7
82.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr7:136894611-137128187 bp, + strand
From Ensembl annotation of GRCm38

  233577 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: methylated-DNA--protein-cysteine methyltransferase
Gene Tree: Mgmt

Human
homologs
Human Homolog MGMT, O-6-methylguanine-DNA methyltransferase
NCBI Gene ID 4255
neXtProt AC  NX_P16455
Human Chr (Location)  10q26; chr10:129467190-129767519 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(18) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for targeted knock-out mutations of this gene display increased sensitivity to various alkylating agents.
 
Interactions
Mgmt interacts with 12 markers (Mir130a, Mir133a-1, Mir133a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular response to DNA damage stimulus, DNA dealkylation involved in DNA repair, ...
Component membrane, nucleus
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(6) cDNA(19)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000054612 (Evidence)
Entrez Gene17314 (Evidence)
UniGene440219
DFCITC1585755, TC1618847
DoTSDT.99690264
NIA Mouse Gene IndexU008895
EC2.1.1.63
Consensus CDS ProjectCCDS21945.1
International Mouse Knockout Project StatusMgmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054612 Ensembl Gene Model | MGI Sequence Detail 233577 C57BL/6J ±  kb
transcript ENSMUST00000081510 Ensembl | MGI Sequence Detail 818 Not Applicable 
polypeptide ENSMUSP00000080224 Ensembl | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(14) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(1915 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
InterPro IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
InterPro IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000010388 methylated-DNA--protein-cysteine methyltransferase
References
(Earliest) J:519 Rouleau J, et al., The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter. J Biol Chem. 1992 Apr 15;267(11):7368-77
(Latest) J:174431 Kisby GE, et al., The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner. PLoS One. 2011;6(6):e20911
All references(75)
Other
accession IDs
MGD-MRK-1181, MGD-MRK-12222, MGI:2141895, MGI:87956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory