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Mgmt Gene Detail
Summary
  • Symbol
    Mgmt
  • Name
    O-6-methylguanine-DNA methyltransferase
  • Synonyms
    Agat, AGT
  • Feature Type
    protein coding gene
  • IDs
    MGI:96977
    NCBI Gene: 17314
Location & Maps
more
  • Sequence Map
    Chr7:136894611-137128187 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      233577 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 82.07 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    MGMT, O-6-methylguanine-DNA methyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MGMT, O-6-methylguanine-DNA methyltransferase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 4255
    neXtProt AC: NX_P16455

  • Chr Location
    10q26; chr10:129467190-129768042 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Gene trapped
    18
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
    APF
Mice homozygous for targeted knock-out mutations of this gene display increased sensitivity to various alkylating agents.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054612 Ensembl Gene Model | MGI Sequence Detail 233577 C57BL/6J ±  kb
transcript ENSMUST00000081510 Ensembl | MGI Sequence Detail 818 Not Applicable  
polypeptide ENSMUSP00000080224 Ensembl | MGI Sequence Detail 211 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1909 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010388 methylated-DNA--protein-cysteine methyltransferase
  • EC
  • InterPro Domains
    IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
    IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
    IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 25
    Genomic 6
    cDNA 19

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1181, MGD-MRK-12222, MGI:2141895, MGI:87956
References
more
  • Summaries
    All 74
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 28
  • Earliest
    J:519 Rouleau J, et al., The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter. J Biol Chem. 1992 Apr 15;267(11):7368-77
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory