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Mgp
Gene Detail
 Symbol
Name
ID
Mgp
matrix Gla protein
MGI:96976
Synonyms Mglap
Feature Type protein coding gene
Genetic Map
Chromosome 6
66.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:136872436-136875805 bp, - strand
From Ensembl annotation of GRCm38

  3370 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: osteocalcin
Gene Tree: Mgp

Human
homologs
Human Homolog MGP, matrix Gla protein
NCBI Gene ID 4256
neXtProt AC  NX_P08493
Human Synonyms  MGLAP, NTI
Human Chr (Location)  12p12.3; chr12:14881181-14885919 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MGP
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
 
Homozygotes for a targeted null mutation exhibit growth plate calcification leading to reduced stature, osteopenia, and fractures, and arterial calcification and rupture resulting in death by eight weeks of age.
 
Human Diseases Modeled Using Mouse Mgp (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process branching morphogenesis of an epithelial tube, cartilage development, ...
Component endoplasmic reticulum, extracellular matrix, ...
Function calcium-dependent protein binding, calcium ion binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (176)    Tissues (172)    Images (24)
Theiler Stages: 17, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 171
Northern blot 3
RT-PCR 2
cDNA source data(120)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(124) Genomic(2) cDNA(120) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030218 (Evidence)
Entrez Gene17313 (Evidence)
UniGene243085
DoTSDT.55253476
NIA Mouse Gene IndexU027978
Consensus CDS ProjectCCDS20659.1
International Mouse Knockout Project StatusMgp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030218 Ensembl Gene Model | MGI Sequence Detail 3370 C57BL/6J ±  kb
transcript ENSMUST00000032342 Ensembl | MGI Sequence Detail 598 Not Applicable 
polypeptide ENSMUSP00000032342 Ensembl | MGI Sequence Detail 104 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR027118 Matrix Gla protein
InterPro IPR002384 Osteocalcin/matrix Gla protein
Protein Ontology PR:000010389 matrix Gla protein
References (Earliest) J:612 Ikeda T, et al., cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence. J Bone Miner Res. 1991 Sep;6(9):1013-7
(Latest) J:205998 Beazley KE, et al., Attenuation of chondrogenic transformation in vascular smooth muscle by dietary quercetin in the MGP-deficient mouse model. PLoS One. 2013;8(9):e76210
All references(53)
Other
accession IDs
MGD-MRK-12221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory