Mgp
Gene Detail

Symbol Name ID

Mgp matrix Gla protein MGI:96976

Synonyms

Mglap

Feature Type

protein coding gene

Genetic Map

Chromosome 6

66.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:136872436-136875805 bp, - strand From Ensembl annotation of GRCm38   3370 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: osteocalcin
Gene Tree: Mgp

Human homologs

Human Homolog		MGP, matrix Gla protein
NCBI Gene ID		4256
neXtProt AC		NX_P08493
Human Synonyms		MGLAP, NTI
Human Chr (Location)		12p12.3; chr12:15034115-15038853 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MGP

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygotes for a targeted null mutation exhibit growth plate calcification leading to reduced stature, osteopenia, and fractures, and arterial calcification and rupture resulting in death by eight weeks of age.

 
Human Diseases Modeled Using Mouse Mgp (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	branching morphogenesis of an epithelial tube, cartilage development, ...
Component	endoplasmic reticulum, extracellular matrix, ...
Function	calcium-dependent protein binding, calcium ion binding

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (134)    Tissues (130)    Images (22)
Theiler Stages: 17, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	129
Northern blot	3
RT-PCR	2

cDNA source data(120)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(124) Genomic(2) cDNA(120) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030218 (Evidence)
Entrez Gene	17313 (Evidence)
UniGene	243085
DoTS	DT.55253476
NIA Mouse Gene Index	U027978
Consensus CDS Project	CCDS20659.1
International Mouse Knockout Project Status	Mgp

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030218	Ensembl Gene Model | MGI Sequence Detail	3370	C57BL/6J
transcript	ENSMUST00000032342	Ensembl | MGI Sequence Detail	598	Not Applicable
polypeptide	ENSMUSP00000032342	Ensembl | MGI Sequence Detail	104	Not Applicable

All sequences(22) RefSeq(2) UniProt(4)

Polymorphisms

SNPs within 2kb(104 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro	IPR027118	Matrix Gla protein
InterPro	IPR002384	Osteocalcin/matrix Gla protein
Protein Ontology	PR:000010389	matrix Gla protein

References

(Earliest) J:612 Ikeda T, et al., cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence. J Bone Miner Res. 1991 Sep;6(9):1013-7
(Latest) J:185158 Yao Y, et al., Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood. 2012 May 24;119(21):5037-47
All references(50)

Other accession IDs

MGD-MRK-12221