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Mgp Gene Detail
Summary
  • Symbol
    Mgp
  • Name
    matrix Gla protein
  • Synonyms
    Mglap
  • Feature Type
    protein coding gene
  • IDs
    MGI:96976
    NCBI Gene: 17313
  • Gene Overview
    MyGene.info: MGP
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:136849433-136852821 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 66.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96976
protein coding gene Chr6:136849433-136852821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031430
protein coding gene Chr6:141376511-141379923 (-)
A/J MGP_AJ_G0031405
protein coding gene Chr6:135764352-135767770 (-)
AKR/J MGP_AKRJ_G0031333
protein coding gene Chr6:139897015-139900433 (-)
BALB/cJ MGP_BALBcJ_G0031412
protein coding gene Chr6:135636924-135640336 (-)
C3H/HeJ MGP_C3HHeJ_G0031134
protein coding gene Chr6:139927203-139930621 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031874
protein coding gene Chr6:145213098-145216486 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029003
protein coding gene Chr6:134879383-134882794 (-)
CAST/EiJ MGP_CASTEiJ_G0030502
protein coding gene Chr6:139437322-139442331 (-)
CBA/J MGP_CBAJ_G0031094
protein coding gene Chr6:150653620-150657038 (-)
DBA/2J MGP_DBA2J_G0031251
protein coding gene Chr6:134639679-134643097 (-)
FVB/NJ MGP_FVBNJ_G0031202
protein coding gene Chr6:133539419-133542837 (-)
LP/J MGP_LPJ_G0031335
protein coding gene Chr6:141483939-141487351 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031242
protein coding gene Chr6:154536456-154539874 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031906
protein coding gene Chr6:139642223-139645635 (-)
PWK/PhJ MGP_PWKPhJ_G0030229
protein coding gene Chr6:133139457-133142855 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030053
protein coding gene Chr6:137905473-137908907 (-)
WSB/EiJ MGP_WSBEiJ_G0030595
protein coding gene Chr6:140281470-140284882 (-)



Homology
more
  • Human Ortholog
    MGP, matrix Gla protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGP, matrix Gla protein
  • Synonyms
    GIG36, MGLAP, NTI
  • Links
    NCBI Gene ID: 4256
    neXtProt AC: NX_P08493
    UniProt: P08493

  • Chr Location
    12p12.3; chr12:14881181-14885919 (-)  GRCh38.p7

  • Alliance of Genome Resources
    Mgp stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: MGP
  • Gene Tree
    Mgp
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit growth plate calcification leading to reduced stature, osteopenia, and fractures, and arterial calcification and rupture resulting in death by eight weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17313 NCBI Gene Model | MGI Sequence Detail 3389 C57BL/6J ±  kb
    transcript NM_008597 RefSeq | MGI Sequence Detail 632 C57BL/6  
    polypeptide P19788 UniProt | EBI | MGI Sequence Detail 104 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 128
      Genomic 2
      cDNA 121
      Primer pair 2
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12221
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 17
      Gene Ontology 4
      Phenotypes 31
    • Earliest
      J:612 Ikeda T, et al., cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence. J Bone Miner Res. 1991 Sep;6(9):1013-7
    • Latest
      J:297060 DeSisto J, et al., Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function. Dev Cell. 2020 Jul 6;54(1):43-59.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/23/2021
    MGI 6.17
    The Jackson Laboratory