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Mgp Gene Detail
Summary
  • Symbol
    Mgp
  • Name
    matrix Gla protein
  • Synonyms
    Mglap
  • Feature Type
    protein coding gene
  • IDs
    MGI:96976
    NCBI Gene: 17313
  • Gene Overview
    MyGene.info: MGP
Location & Maps
more
  • Sequence Map
    Chr6:136872435-136875823 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3389 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 66.72 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MGP, matrix Gla protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MGP, matrix Gla protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GIG36, MGLAP, NTI
  • Links
    NCBI Gene ID: 4256
    neXtProt AC: NX_P08493

  • Chr Location
    12p12.3; chr12:14881181-14885919 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mgp mouse models; 1 with human MGP associations

Human Disease Mouse Models
       Keutel Syndrome; KTLS   OMIM: 245150 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    1
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit growth plate calcification leading to reduced stature, osteopenia, and fractures, and arterial calcification and rupture resulting in death by eight weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057425 VEGA Gene Model | MGI Sequence Detail 3389 C57BL/6J ±  kb
transcript OTTMUST00000141259 VEGA | MGI Sequence Detail 617 Not Applicable  
polypeptide OTTMUSP00000073851 VEGA | MGI Sequence Detail 104 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    104 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010389 matrix Gla protein
  • InterPro Domains
    IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    IPR027118 Matrix Gla protein
    IPR002384 Osteocalcin/matrix Gla protein
Molecular
Reagents
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  • All nucleic 124
    Genomic 2
    cDNA 120
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12221
References
more
  • Summaries
    All 56
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:612 Ikeda T, et al., cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence. J Bone Miner Res. 1991 Sep;6(9):1013-7
  • Latest
    J:230973 Borras T, et al., A Novel Mgp-Cre Knock-In Mouse Reveals an Anticalcification/Antistiffness Candidate Gene in the Trabecular Meshwork and Peripapillary Scleral Region. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2203-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory